Abstract:
BACKGROUND:Despite a high prevalence of hypertension in the population with CAD, there are limited data describing the clinical characteristics and treatments, as well as their interrelations in these patients. This is particularly true for black and Hispanic patients who have been underrepresented in randomized CAD trials. HYPOTHESIS:There exist racial and ethnic differences that define the characteristics of patients with both coronary artery disease (CAD) and hypertension. METHODS:This report describes the characteristics of Caucasian, Hispanic, and black patients enrolled in the International Verapamil SR/trandolapril Study (INVEST), a prospective trial undertaken exclusively in patients with CAD and hypertension. RESULTS:In all, 10,925 Caucasian, 8,045 Hispanic, and 3,029 black patients are described. An abnormal angiogram or documented myocardial infarction was observed more frequently in Caucasian patients (73%), while angina pectoris was more prevalent in Hispanic patients (87%). Diabetes and left ventricular hypertrophy were most common in black patients (33 and 29%, respectively), while hypercholesterolemia and prior revascularization (coronary artery bypass graft or angioplasty) were most common in Caucasian patients (64 and 41%, respectively). More than 60% of Hispanic and black patients were women--a unique characteristic for randomized CAD trials. Comparing race/ethnic cohorts, there were significant differences for all characteristics. More than 80% of patients in all race/ethnic groups were receiving antihypertensive therapy; however, only fewer than 25% had controlled blood pressure according to guidelines from the sixth report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. CONCLUSIONS:This high-risk population of hypertensive patients with CAD has been undertreated and does not have well-controlled BP. Race/ethnic differences were observed for clinical characteristics and medication use.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Cooper-DeHoff RM,Handberg EM,Cohen J,Kowey P,Messerli FH,Mancia G,Cangiano JL,Gaxiola E,Garcia-Barreto D,Hewkin AC,Pepine CJ,INVEST Investigators.doi
10.1002/clc.4960271010subject
Has Abstractpub_date
2004-10-01 00:00:00pages
571-6issue
10eissn
0160-9289issn
1932-8737journal_volume
27pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract:BACKGROUND AND HYPOTHESIS:Although it is well established that diabetes mellitus (DM) induces more severe coronary artery disease (CAD), it is not known whether it contributes to the development of coronary collateral circulation. The present study examines coronary collateral circulation in diabetic and nondiabetic pa...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220706
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Pulse pressure (PP) has recently been found to be predictive of subsequent cardiovascular, particularly coronary, events in some middle-aged and elderly populations. HYPOTHESIS:The aim of this prospective population-based study was to evaluate the roles of systolic (SBP), diastolic blood pressure (DBP), and...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960260209
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:Systemic hypertension is the leading cause of left ventricular (LV) hypertrophy. The present study aimed to investigate the mechanism of left atrial (LA) enlargement in patients with hypertensive heart disease during cardiac catheterization. METHODS:Data were obtained from eight control subje...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960191211
更新日期:1996-12-01 00:00:00
abstract::In-coordinate mitral annulus movement might participate in the pathogenesis of functional mitral regurgitation. We evaluated a relationship between indices of mitral annulus systolic asynchrony and mitral regurgitation in patients after myocardial infarction in order to determine independent determinants of effective ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20131
更新日期:2007-10-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.10
更新日期:2007-05-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.22838
更新日期:2017-12-01 00:00:00
abstract::The purpose of this paper is to review the history of the clinico-pathologic investigations performed at the University of Padua on an old morbid entity ("parchment heart"), which, in the 1960s, led to the clinical description of the disease, in the 1980s to the revival of the scientific interest, and in the mid 1990s...
journal_title:Clinical cardiology
pub_type: 历史文章,杂志文章
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更新日期:1997-04-01 00:00:00
abstract::Balancing the benefits, risks, and cost of thrombolytic treatment is a complex issue which depends considerably upon the variable threat of the thrombus to organ physiology and patient survival. For example, after deep vein thrombosis (DVT), the major risk is long-term disability due to the postphlebitic syndrome, whi...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1990-04-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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更新日期:2000-03-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960181006
更新日期:1995-10-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 社论
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更新日期:2002-08-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2019-05-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960200416
更新日期:1997-04-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960181117
更新日期:1995-11-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960200321
更新日期:1997-03-01 00:00:00
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doi:10.1002/clc.4960230505
更新日期:2000-05-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-06-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960150713
更新日期:1992-07-01 00:00:00
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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更新日期:1984-06-01 00:00:00
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-04-01 00:00:00
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更新日期:2002-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/clc.4960270412
更新日期:2004-04-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960200514
更新日期:1997-05-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100413
更新日期:1987-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
abstract::Although Hemophilus influenzae infections have long been considered to be a disease of childhood, recent reports have demonstrated an increasing frequency of serious Hemophilus influenzae infections in adults. A case of purulent H. influenzae pericarditis in a previously healthy adult without evidence of concurrent H....
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960051008
更新日期:1982-10-01 00:00:00