Evaluation of insulin resistance in normoglycemic patients with coronary artery disease.


BACKGROUND:Insulin resistance is clearly associated with coronary artery disease (CAD) in diabetics. Insulin resistance may also be present in normoglycemic individuals, and some of these patients can be diagnosed as having metabolic syndrome (MS) according to various definitions. However, the relationship between hyperinsulinemia and CAD is obscure in normoglycemic individuals, especially in patients who do not meet the criteria for MS. HYPOTHESIS:This study evaluated insulin resistance in normoglycemic patients with CAD, and investigated the association of insulin resistance with inflammation and lipid levels. METHODS:Fifty-six CAD patients, and 57 age- and sex-matched controls with normal coronary arteries confirmed by conventional coronary arteries angiography were included in the study. Participants were considered for the diagnosis of MS according to criteria of the National Cholesterol Education Program (NCEPATP III) and the International Diabetes Federation (IDF). Fasting plasma glucose, insulin, lipids, and c-reactive protein (CRP) levels were studied. The homeostasis model assessment insulin resistance index (HOMA IR) was calculated. RESULTS:The ratio of subjects with MS was similar in the 2 groups. Insulin, CRP, low-density lipoprotein (LDL) cholesterol, and HOMA IR were higher in the study group than in the controls. The HOMA IR, LDL cholesterol, and serum CRP levels were determined as predictors of CAD. CONCLUSION:Our data revealed that insulin resistance and subclinical inflammation are present in normoglycemic patients with CAD. As the proportion of patients with MS was similar in the 2 groups, we suggest that HOMA IR values may provide more sensitive information than MS definitions about the association between insulin resistance and CAD in normoglycemic patients.


Clin Cardiol


Clinical cardiology


Deveci E,Yesil M,Akinci B,Yesil S,Postaci N,Arikan E,Koseoglu M




Has Abstract


2009-01-01 00:00:00












  • Dynamic cardiomyoplasty for treatment of heart failure.

    abstract::Dynamic cardiomyoplasty is a new surgical procedure proposed for treatment of the failing heart. Clinically, the latissimus dorsi muscle is raised as a pedicled flap and wrapped around the heart. The skeletal muscle is transformed to produce a myocardium-like fatigue-resistant muscle. It is stimulated to contract in s...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审


    authors: Hill AB,Chiu RC

    更新日期:1989-12-01 00:00:00

  • Long-term follow-up by exercise radionuclide angiography of patients after valve replacement for aortic regurgitation.

    abstract::The long-term effects of valve replacement for chronic isolated aortic regurgitation as assessed by first-pass exercise radionuclide angiography have never been reported. We studied 20 males and 5 females before, 15 months postoperatively, and from 29 to 109 (mean 62 +/- 21) months following valve replacement with exe...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Lumia FJ,LaManna M,Gonzalez-Lavin L,Maranhao V

    更新日期:1988-04-01 00:00:00

  • Determinants and prognostic implications of reperfusion injury during primary percutaneous coronary intervention in Chinese patients with acute myocardial infarction.

    abstract:BACKGROUND:The poor clinical outcome in acute myocardial infarction (AMI) patients undergoing primary percutaneous coronary intervention (PCI) has been attributed to myocardial ischemia-reperfusion injury (MIRI). OBJECTIVE:This study aimed to identify the predictive factors of MIRI during PCI in Chinese AMI patients w...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Luo Y,Li GL,Pan YZ,Zhou SF

    更新日期:2009-03-01 00:00:00

  • Antiarrhythmic drug therapy for atrial fibrillation: are the guidelines guiding clinical practice?

    abstract::The AFFIRM study showed no clear survival advantage for a rhythm versus rate control strategy in patients with atrial fibrillation (AF). However, rhythm control with antiarrhythmic drugs (AADs) is appropriate in a large number of patients with AF. The American College of Cardiology/ American Heart Association/European...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审


    authors: Reiffel JA,Naccarelli GV

    更新日期:2006-03-01 00:00:00

  • Serial analyses of C-reactive protein and myeloperoxidase in acute coronary syndrome.

    abstract:BACKGROUND:C-reactive protein (CRP) and myeloperoxidase (MPO) are involved in the pathogenesis of atherosclerosis, mainly during periods of instabilization. This study aims to test the hypothesis that patients with acute coronary syndrome (ACS) maintain a persistent inflammatory state, and that this is associated with ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Borges FK,Borges FK,Stella SF,Souza JF,Wendland AE,Werres Junior LC,Ribeiro JP,Polanczyk CA

    更新日期:2009-11-01 00:00:00

  • Comparison of coronary collateral circulation in diabetic and nondiabetic patients suffering from coronary artery disease.

    abstract:BACKGROUND AND HYPOTHESIS:Although it is well established that diabetes mellitus (DM) induces more severe coronary artery disease (CAD), it is not known whether it contributes to the development of coronary collateral circulation. The present study examines coronary collateral circulation in diabetic and nondiabetic pa...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Melidonis A,Tournis S,Kouvaras G,Baltaretsou E,Hadanis S,Hajissavas I,Tsatsoulis A,Foussas S

    更新日期:1999-07-01 00:00:00

  • The impact of processes of care on myocardial infarct size in patients with ST-segment elevation myocardial infarction: observations from the CRISP-AMI trial.

    abstract:BACKGROUND:Primary percutaneous coronary intervention (PCI) is the most common method of reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) in the United States. The intersection between processes of care and performance measures such as door-to-balloon (D2B) times and clinical trials evalu...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Jones WS,Clare RM,Chiswell K,Perera D,French JK,Kumar AS,Blaxill J,Pijls N,Mills J,Ohman EM,Patel MR

    更新日期:2015-01-01 00:00:00

  • Cardiovascular anomalies in children and young adults with Ullrich-Turner syndrome the Erlangen experience.

    abstract:BACKGROUND:Females with Ullrich-Turner syndrome (UTS) have typical clinical features such as short stature, ovarian failure, visible dysmorphic stigmata, and abnormalities in different organs such as kidney or heart. HYPOTHESIS:The aim of the present study was to analyze the distribution, prevalence, and relative risk...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Völkl TM,Degenhardt K,Koch A,Simm D,Dörr HG,Singer H

    更新日期:2005-02-01 00:00:00

  • Effect of remote ischemic preconditioning on electrophysiological and biomolecular parameters in nonvalvular paroxysmal atrial fibrillation (RIPPAF study): Rationale and study design of a randomized, controlled clinical trial.

    abstract::Remote ischemic preconditioning (RIPC) has been studied in models of different cardiovascular entities. Recently, a beneficial effect of RIPC on incidence of atrial fibrillation (AF) in postsurgical patients has been suggested. However, the potential impact of RIPC on electrophysiological- and thrombogenesis-related p...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Kosiuk J,Milani R,Ueberham L,Uhe T,Stegmann C,Hindricks G,Bollmann A

    更新日期:2016-11-01 00:00:00

  • Improvement of exercise capacity after nifedipine in patients with Eisenmenger syndrome complicating ventricular septal defect.

    abstract::We investigated the potential benefit of a preferential pulmonary vasodilatory effect of nifedipine in 4 patients with Eisenmenger syndrome complicating ventricular septal defect. First-pass radionuclide scan was performed at rest to measure intracardiac shunting before and after nifedipine. Two hours after 20 mg subl...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章


    authors: Wong CK,Yeung DW,Lau CP,Cheng CH,Leung WH

    更新日期:1991-12-01 00:00:00

  • Stroke and atrial fibrillation: to anticoagulate or not.

    abstract::After reviewing these published studies, I think one can conclude that in the patient population with chronic and/or paroxysmal atrial fibrillation, warfarin is beneficial and the benefits outweigh the risks. However, it is important to point out that patients at high risk for embolic disease, for example, dilated car...

    journal_title:Clinical cardiology

    pub_type: 社论


    authors: Conti CR

    更新日期:1993-07-01 00:00:00

  • Effect of cardiopulmonary bypass on cytokine network and myocardial cytokine production.

    abstract:BACKGROUND:In addition to the well-investigated proinflammatory cytokine expression, there is an ever increasing interest in the field of anti-inflammatory response to cardiopulmonary bypass (CPB). Evidence suggests that myocardium serves as an important source of cytokines during reperfusion and application of CPB. Th...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Gasz B,Lenard L,Racz B,Benko L,Borsiczky B,Cserepes B,Gal J,Jancso G,Lantos J,Ghosh S,Szabados S,Papp L,Alotti N,Roth E

    更新日期:2006-07-01 00:00:00

  • Adverse reactions to protamine sulfate following cardiac surgery.

    abstract::We report four patients who developed severe adverse reactions to protamine sulfate following cardiac surgery. Two types of reactions were seen. First, an immediate anaphylaxis which is a complement-dependent IgG antibody-mediated reaction. In the literature, 80% of patients who had similar reactions have had previous...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Holland CL,Singh AK,McMaster PR,Fang W

    更新日期:1984-03-01 00:00:00

  • Computer errors in electrocardiography.

    abstract::Computer interpretation of electrocardiograms is far from adequate. This paper highlights a particular type of computer error that is merely symbolic of the large number of errors the computer can make. In addition to computer errors in electrocardiography, it is likely that computer interpretation has diminished the ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Hurst JW,Treasure CB,Sathavorn CS

    更新日期:1996-07-01 00:00:00

  • Management of acute myocardial infarction 1990: a perspective.

    abstract::Rising costs have reached a point at which physicians must assume a major role in dealing with the cost of medicine. Little information is available regarding actual practice at the community hospital level. In order to develop some insight on this issue, a survey of cardiovascular specialists was conducted regarding ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Vogel JH

    更新日期:1991-01-01 00:00:00

  • Twenty-four-hour ambulatory oxygen desaturation and electrocardiographic recording in obstructive sleep apnea syndrome.

    abstract:BACKGROUND:Although nocturnal pulseoximetry is routinely performed in obstructive sleep apnea syndrome (OSAS), pulseoximetry over a 24-h period has not been studied. HYPOTHESIS:The purpose of the study was to determine whether simultaneous 24-h oxygen desaturation and electrocardiographic (ECG) recording might be used...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Noda A,Ito R,Okada T,Yasuma F,Nakashima N,Yokota M

    更新日期:1998-07-01 00:00:00

  • Relative efficacy and safety of ticagelor vs clopidogrel as a function of time to invasive management in non-ST-segment elevation acute coronary syndrome in the PLATO trial.

    abstract:BACKGROUND:Guidelines suggest that "upstream" P2Y12 receptor antagonists should be considered in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). HYPOTHESIS:Early use of ticagrelor in patients managed with an invasive strategy would be more effective than clopidogrel because of its more rapi...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pollack CV Jr,Davoudi F,Diercks DB,Becker RC,James SK,Lim ST,Schulte PJ,Spinar J,Steg PG,Storey RF,Himmelmann A,Wallentin L,Cannon CP,PLATO Investigators.

    更新日期:2017-06-01 00:00:00

  • Long-term survival of a patient with left ventricular free wall rupture without surgical repair.

    abstract::This report describes the case of a patient who developed postinfarction left ventricular free wall rupture and cardiac tamponade. He was managed conservatively, made a successful recovery, and is alive and asymptomatic 10 months after the index episode. Only 17 cases in which the patients survived subacute rupture of...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Mathew TP,Johnston PW,Khan MM,Adgey AA

    更新日期:1999-03-01 00:00:00

  • Elevated serum cardiac troponin in non-acute coronary syndrome.

    abstract::Cardiac troponins (CTn) are the most sensitive and specific biochemical markers of myocardial injury and risk stratification. The assay for troponin T (cTnI) is standardized, and results obtained from different institutions are comparable. This is not the case with troponin I (cTnT), and clinicians should be aware tha...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审


    authors: Agzew Y

    更新日期:2009-01-01 00:00:00

  • Initial presenting electrocardiogram as determinant for hospital admission in patients presenting to the emergency department with chest pain: a pilot investigation.

    abstract:BACKGROUND:Evaluation of chest pain accounts for millions of costly Emergency Department (ED) visits and hospital admissions annually. Of these, approximately 10-20% are myocardial infarctions (MI). HYPOTHESIS:Patients with chest pain whose initial electrocardiogram (ECG) is normal do not require hospital admission fo...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Challa PK,Smith KM,Conti CR

    更新日期:2007-11-01 00:00:00

  • Unexplained syncope: implications of age and gender on patient characteristics and evaluation, the diagnostic yield of an implantable loop recorder, and the subsequent treatment.

    abstract:BACKGROUND:Syncope is a common clinical problem with a variety of underlying mechanisms, some of which occur more frequently in 1 of the sexes or at a certain age. HYPOTHESIS:There may be clinically significant age- and gender-related differences in patients with unexplained syncope. METHODS:Five hundred seventy pati...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Edvardsson N,Garutti C,Rieger G,Linker NJ,PICTURE Study Investigators.

    更新日期:2014-10-01 00:00:00

  • Magnetic resonance imaging (MRI) in different stages of myocardial infarction using the contrast agent gadolinium-DTPA.

    abstract::We investigated 26 patients admitted to our catheterization laboratory with a diagnosis of acute myocardial infarction. In each case acute revascularization was unsuccessful, but the diagnosis was confirmed by angiography. In 11 patients with an uncomplicated course of acute myocardial infarction magnetic resonance im...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Eichstaedt HW,Felix R,Dougherty FC,Langer M,Rutsch W,Schmutzler H

    更新日期:1986-11-01 00:00:00

  • Intracardiac teratoma in a newborn.

    abstract::Primary tumors of the heart are infrequent at all ages. We present a newborn with hypoxia and a heart murmur, in whom an echocardiogram revealed a large tumor filling the right ventricle and the pulmonary annulus. To maintain pulmonary blood flow, the patency of the ductus arteriosus was achieved by infusion of prosta...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Farooki ZQ,Chang CH,Jackson WL,Clapp SK,Hakimi M,Arciniegas E,Pinsky WW

    更新日期:1988-09-01 00:00:00

  • Culprit plaque characteristics in women vs men with a first ST-segment elevation myocardial infarction: In vivo optical coherence tomography insights.

    abstract:BACKGROUND:It is unclear whether more severe coronary atherosclerosis is a prerequisite to an initial acute coronary event in women vs men. HYPOTHESIS:Women may have more severe coronary atherosclerosis than men in patients with acute coronary event. METHODS:We used intravascular optical coherence tomography (OCT) to...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Sun R,Sun L,Fu Y,Liu H,Xu M,Ren X,Yu H,Dong H,Liu Y,Zhu Y,Tian J,Yu B

    更新日期:2017-12-01 00:00:00

  • Chronic Chagas' heart disease presenting as an impending myocardial infarction: a case favoring the neurogenic pathogenesis concept.

    abstract::A 55-year-old Caucasian woman suddenly developed substernal chest pain at rest accompanied by pallor, diaphoresis, nausea, and vomiting. Physical examination was otherwise unremarkable. The resting ECG showed T-wave inversion in all anterior leads which returned to normal 24 h after the onset of the symptoms. The pain...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Bestetti RB,Finzi LA,Oliveira JS

    更新日期:1987-06-01 00:00:00

  • Clinical features, use of evidence-based therapies, and cardiovascular outcomes among patients with chronic kidney disease following non-ST-elevation acute coronary syndrome.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular events following acute coronary syndrome (ACS). The underlying pathobiology and optimal treatments for this population continue to be evaluated. HYPOTHESIS:Patients with CKD will receive fewer evidence-based therapies and ex...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rhee JW,Wiviott SD,Scirica BM,Gibson CM,Murphy SA,Bonaca MP,Morrow DA,Mega JL

    更新日期:2014-06-01 00:00:00

  • Finding the vulnerable plaque.

    abstract::At a recent Transcatheter Therapeutics meeting in San Francisco the PROSPECT Trial was presented by Dr. Greg Stone. Prospect stands for Providing Regional Observations to Study Predictors of Events in the Coronary Tree. This was a natural history study of atherosclerosis using multi-modality intracoronary imaging to p...

    journal_title:Clinical cardiology

    pub_type: 社论


    authors: Conti CR

    更新日期:2010-06-01 00:00:00

  • Paradoxical ventricular septal motion with right ventricular dilatation as a manifestation of pure pressure overload due to pulmonary veno-occlusive disease.

    abstract::Paradoxical interventricular septal motion with right ventricular dilatation has been considered the hallmark of right ventricular volume overload. We report a 43-year-old woman with severe pulmonary hypertension due to pulmonary veno-occlusive disease who exhibited these echocardiographic abnormalities. Right ventric...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Zee-Cheng CS,Gibbs HR

    更新日期:1985-11-01 00:00:00

  • Transient left ventricular aneurysm in a patient with hypertrophic cardiomyopathy and myocarditis.

    abstract::Left ventricular wall motion abnormalities, aneurysm formation, and progression to global hypokinesis have been described in patients with myocarditis and in patients with hypertrophic cardiomyopathy. We document a case of reversible aneurysm formation, cardiogenic shock, and complete recovery in a patient with myocar...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Fisher DZ,DiSalvo TG,Dec GW,DeSanctis RW

    更新日期:1993-03-01 00:00:00

  • Two cases with similar pseudoaneurysms but different outcomes.

    abstract::The pseudoaneurysm is a rare cardiac pathology, in which the left ventricular free wall ruptures and the pericardium surrounds the rupture in combination with thrombus and inflammation and thus prevents the development of a hemopericardium. Left ventricular pseudoaneurysm may remain silent unless it gives rise to card...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Bildirici U,Agacdiken A,Ural E,Kahraman G,Komsuoglu B

    更新日期:2009-06-01 00:00:00