Abstract:
BACKGROUND:Patients with sinus node dysfunction (SND) have increased risk of atrial tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns and outcomes of patients with SND and AF have not been well described. HYPOTHESIS:Patients with SND and AF have higher risk of adverse cardiovascular outcomes. METHODS:Sinus node dysfunction was defined clinically, based on treating physician. Treatment patterns were described and logistic regression analysis performed to assess outcomes. RESULTS:Overall, 1710 (17.7%) out of 9631 patients had SND at enrollment. Patients with SND and AF had increased comorbid medical illnesses, more severe symptoms (European Heart Rhythm Association class IV: 17.5% vs 13.9%; P = 0.0007), and poorer quality of life (median 12-month Atrial Fibrillation Effect on Quality of Life score: 79.6 vs 85.2; P = 0.0008). There were no differences in AF management strategy between patients with SND and those without (rate control, 69.7% vs 67.7%; rhythm control, 30.0% vs 32.0%; P = 0.11). After adjustment, patients with SND were more likely than those without SND to progress from paroxysmal AF at baseline to persistent or permanent AF at any follow-up, or persistent AF at baseline to permanent AF at any follow-up (odds ratio: 1.23, 95% confidence interval: 1.01-1.49, P = 0.035). However, there was no association between SND and major risk-adjusted outcomes. CONCLUSIONS:Sinus node dysfunction is present in 1 of 6 patients with AF and is associated with increased comorbidities and higher symptom burden. However, SND is not associated with an increase in major risk-adjusted outcomes.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Jackson LR 2nd,Kim SH,Piccini JP Sr,Gersh BJ,Naccarelli GV,Reiffel JA,Freeman J,Thomas L,Chang P,Fonarow GC,Go AS,Mahaffey KW,Peterson ED,Kowey PRdoi
10.1002/clc.22504subject
Has Abstractpub_date
2016-02-01 00:00:00pages
119-25issue
2eissn
0160-9289issn
1932-8737journal_volume
39pub_type
杂志文章,多中心研究abstract:BACKGROUND:In this study, we evaluated the feasibility and clinical usefulness of TS(E-E(') ), the time interval between the onsets of early diastolic mitral inflow velocity (E) and mitral annular velocity (E'), obtained by simultaneously tracing E and E', in terms of evaluating diastolic function. METHODS:By the dias...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20241
更新日期:2008-08-01 00:00:00
abstract::A 25-year-old man presented with cardiogenic shock secondary to rheumatic mitral stenosis. Despite aggressive medical treatment he continued to deteriorate. This report describes the successful use of the metallic valvulotome technique for mitral commissurotomy in the context of a critically ill patient. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270616
更新日期:2004-06-01 00:00:00
abstract::We have studied the changes induced in atherosclerotic arteries by a CO2 laser beam delivered through a silver halide optical fiber. We found that the crater depth and diameter correlate with the total energy delivered and with the mode of delivery. Short-duration high-power pulses caused shallower and narrower crater...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090302
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:The right bundle branch block (RBBB) and the bifascicular blocks affect QRS duration in the right precordial leads, which are usually used for QT interval determination. Up to now, there is no clear recommendation how to determine QT interval in patients with RBBB or bifascicular block. HYPOTHESIS:The hypot...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23389
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The real-world impact of remote pulmonary artery pressure (PAP) monitoring on New York Heart Association (NYHA) class improvement and heart failure (HF) hospitalization rate is presented here from a single center. HYPOTHESIS:METHODS: Seventy-seven previously hospitalized outpatients with NYHA class III HF w...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22643
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease, insulin resistance (IR), and obesity frequently coexist with type 2 diabetes mellitus (DM), but it is uncertain whether these risk factors for vascular disease contribute to a change in atherosclerosis over time, independently of DM status. HYPOTHESIS:We hypothesized that t...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22529
更新日期:2016-06-01 00:00:00
abstract::Recently, a debate over the merits of statin therapy in primary prevention was published in the Wall Street Journal. The statin opponent claimed that statins should only be used in secondary prevention and never in any primary-prevention patients at risk for cardiovascular events. In this evidence-based rebuttal to th...
journal_title:Clinical cardiology
pub_type: 社论,评审
doi:10.1002/clc.22016
更新日期:2012-01-01 00:00:00
abstract::The normal human aorta is not a stiff tube but is characterized by elastic properties with a buffering Windkessel function. Aortic stiffening may cause an increase in aortic pulse pressure, left ventricular load, and ultimately left ventricular hypertrophy. This, together with the decreased diastolic transmyocardial p...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20252
更新日期:2008-07-01 00:00:00
abstract::Rising costs have reached a point at which physicians must assume a major role in dealing with the cost of medicine. Little information is available regarding actual practice at the community hospital level. In order to develop some insight on this issue, a survey of cardiovascular specialists was conducted regarding ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960140104
更新日期:1991-01-01 00:00:00
abstract::Recently two types of atypical T-wave evolution were recognized as electrocardiographic (ECG) markers of regional postinfarction pericarditis. The sensitivity and specificity of these changes for this condition were 100 and 77%, respectively. The major purpose of this investigation is to show how these ECG changes can...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170903
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that viable but stunned myocardium displays contractile reserve and exhibits cardiac cycle-dependent variations of integrated backscatter (CVIB), whereas infarcted myocardium does not. HYPOTHESIS:This study was designed to clarify whether assessment of the acoustic properties of ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960261010
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is the third cause of acute deterioration of renal function in hospitalized patients. HYPOTHESIS:The purpose of the study was to compare the efficacy of saline infusion, saline infusion plus N-acetylcysteine (NAC), and sodium bicarbonate (SB) infusion to prevent CIN in pat...
journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.20576
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Although sudden death (SD) is a rare complication after atrioventricular junction (AVJ) ablation and permanent pacemaker implantation, the risk factors leading to this SD remain unknown. The purpose of this study was to investigate SD and its risk factors after ablate-and-pace strategy for rate control in at...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22600
更新日期:2017-01-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a major independent risk factor for cardiovascular disease, and diabetic dyslipidemia is a major contributor to cardiovascular risk in these patients. Here we report the rationale and design of a phase 3, double-blind study specifically designed to evaluate the lipid-lowering efficac...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.23018
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Previously, the high maternal mortality in cardiac patients who became pregnant prompted the assertion: Women with an abnormal heart should not become pregnant. This long-standing notion needs to be revised today. HYPOTHESIS:The study was undertaken to ascertain the experience with a large series of pregnan...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960260308
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Overt hypothyroidism has been found to be associated with cardiovascular disease. Moreover, subclinical hypothyroidism is a strong indicator of risk for aortic atherosclerosis and myocardial infarction. HYPOTHESIS:We hypothesized that variation of thyroid function within the normal range may influence the p...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960261205
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The frequency of acute myocardial infarction (AMI) peaks on Mondays and in the mornings. However, the distribution of the types of acute coronary syndromes (ACS), including unstable angina (UA), has not been systematically evaluated. HYPOTHESIS:The distribution of the types of ACS and clinical presentations...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22
更新日期:2006-12-01 00:00:00
abstract::A method for noninvasive generation of central aortic systolic pressure curves is presented. The method is based on plotting the occlusive pressure values applied at the brachial artery level against the time intervals needed for the aortic pressure wave to equalize and break through the occlusive pressure at the brac...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100402
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:One-third of patients who receive cardiac resynchronization therapy (CRT) are classified as nonresponders. Characteristics of responders to CRT have been studied in multiple clinical trials. HYPOTHESIS:Independent predictors of CRT response may be identified by studying a series of patients in routine clini...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22043
更新日期:2012-12-01 00:00:00
abstract::A total of 140 consecutive patients with acute Q-wave myocardial infarction was evaluated to assess the relationship between different electrocardiographic patterns of evolution and the incidence of recurrent ischemia within 10 days of infarction. Patients were allocated to three groups according to the electrocardiog...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960181205
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Coronary artery disease (CAD) risk is not fully revealed by traditional risk factors. Identification of a simple, noninvasive tool that allows for detection of high-risk CAD patients and can be applied in large populations and clinical settings would prove valuable. HYPOTHESIS:We sought to test the hypothes...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20705
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Pulmonary capillary wedge pressure (PCWP) is a useful index of preload and an important determinant of cardiac function. HYPOTHESIS:We postulated that the rate of blood propagating into the left atrium (LAIF-PR) would be a useful measure of PCWP in critically ill patients. METHODS:Fifty-two critically ill ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960260412
更新日期:2003-04-01 00:00:00
abstract::Nonpharmacologic therapies for patients with sustained ventricular tachycardia have been necessitated by the low frequency of drug-responsive patients. These nonpharmacologic therapies include antitachycardia pacemakers, low-energy cardioverters, defibrillators, surgery and, for the present, catheter ablation. Antitac...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::The 2011 Update of the American Heart Association's Cardiovascular Disease Prevention Guideline for Women is designed to help women and their physicians understand cardiovascular Disease (CVD) risks and undertake practical steps that are most effective in preventing heart disease and stroke. Defining a woman's risk st...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20940
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Radiation-treated head and neck cancer (HNC) patients are at high risk for developing radiation vasculopathy, as evidenced by an increased stroke risk. The benefits of screening and assessing the cardiovascular (CV) risk of HNC patients using carotid intima-media thickness (CIMT) ultrasound are not known. Ou...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22389
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Investigate the usefulness of echocardiography and acoustic cardiography to monitor patients exposed to anthracycline chemotherapy. HYPOTHESIS:Serial echocardiographies to monitor systolic function may not be neccessary in all patients undergoing anthracycline chemotherapy. METHODS:In a prospective study, ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22074
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Anticoagulation with heparin is recommended with intra-aortic balloon pump (IABP) to prevent thrombosis and embolization. However, anticoagulation increases the risk of bleeding, particularly in combination with glycoprotein (GP) IIb/IIIa antagonists. HYPOTHESIS:We investigated the safety of using GP IIb/II...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20297
更新日期:2009-02-01 00:00:00
abstract::Hyponatremia is common and is increasingly recognized as an independent prognostic marker that adversely affects morbidity and mortality in various disease states, including heart failure. In acute decompensated heart failure (ADHF), the degree of hyponatremia often parallels the severity of cardiac dysfunction and is...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20822
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Atherosclerotic cardiovascular disease is prevalent among renal transplant patients. Increase in serum total cholesterol, low-density lipoprotein, and very low-density lipoprotein is common in those patients. Alterations in chylomicron metabolism, however, are also related to atherogenesis and were not studi...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960210608
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Patients with phenotypic severe hypercholesterolemia (SH), low-density lipoprotein-cholesterol (LDL-c) ≥ 190 mg/dl, atherosclerotic cardiovascular disease (ASCVD) or adults 40-75 years with diabetes with risk factors or 10-year ASCVD risk ≥20% benefit from maximally tolerated statin therapy. Rural patients h...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23521
更新日期:2020-12-23 00:00:00