Abstract:
BACKGROUND:One-third of patients who receive cardiac resynchronization therapy (CRT) are classified as nonresponders. Characteristics of responders to CRT have been studied in multiple clinical trials. HYPOTHESIS:Independent predictors of CRT response may be identified by studying a series of patients in routine clinical practice. METHOD:One hundred twenty-five patients were examined retrospectively from a multidisciplinary CRT clinic program. Echocardiographic CRT response was defined as a decrease in left ventricular (LV) end-systolic volume of ≥15% and/or absolute increase of 5% in LV ejection fraction at the 6-month visit. RESULTS:There were 81 responders and 44 nonresponders. By univariate analyses, female sex, nonischemic cardiomyopathy etiology, baseline QRS duration, the presence of left bundle branch block (LBBB), and left ventricular end-diastolic volume (LVEDV) index predicted CRT response. However, multivariate analysis demonstrated that only QRS duration, LBBB, and LVEDV index were independent predictors (QRS width, odds ratio [OR]: 1.027, 95% confidence interval [CI]: 1.004-1.050, P = 0.023; LBBB, OR: 3.568, 95% CI: 1.284-9.910, P = 0.015; LVEDV index, OR: 0.970, 95% CI: 0.953-0.987, P = 0.001). Although female sex and nonischemic etiology were associated with an improved CRT response on univariate analyses, after adjusting for LV volumes they were not independent predictors. CONCLUSIONS:QRS width, LBBB, and LVEDV index are independent predictors for echocardiographic CRT response. Previously reported differences in CRT response for sex and cardiomyopathy etiology are associated with differences in baseline LV volumes in our clinical practice.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Park MY,Altman RK,Orencole M,Kumar P,Parks KA,Heist KE,Singh JP,Picard MHdoi
10.1002/clc.22043subject
Has Abstractpub_date
2012-12-01 00:00:00pages
777-80issue
12eissn
0160-9289issn
1932-8737journal_volume
35pub_type
杂志文章abstract:BACKGROUND:The frequency of acute myocardial infarction (AMI) peaks on Mondays and in the mornings. However, the distribution of the types of acute coronary syndromes (ACS), including unstable angina (UA), has not been systematically evaluated. HYPOTHESIS:The distribution of the types of ACS and clinical presentations...
journal_title:Clinical cardiology
pub_type: 杂志文章
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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更新日期:1998-11-01 00:00:00
abstract::Malignant lymphoma commonly involves the heart. Previous studies have found cardiac metastases in up to 20% of patients dying with lymphoma. Cardiac signs and symptoms of lymphoma are relatively rare, however, and in most cases, the diagnosis is made either postmortem or too late to affect the clinical course. This re...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190326
更新日期:1996-03-01 00:00:00
abstract::A 55-year-old Caucasian woman suddenly developed substernal chest pain at rest accompanied by pallor, diaphoresis, nausea, and vomiting. Physical examination was otherwise unremarkable. The resting ECG showed T-wave inversion in all anterior leads which returned to normal 24 h after the onset of the symptoms. The pain...
journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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doi:10.1002/clc.4960291008
更新日期:2006-10-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1989-07-01 00:00:00
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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更新日期:1997-11-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22242
更新日期:2014-03-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190605
更新日期:1996-06-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
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journal_title:Clinical cardiology
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更新日期:1992-09-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20986
更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960160317
更新日期:1993-03-01 00:00:00