Arrhythmogenic right ventricular cardiomyopathy: a survey of the investigations at the University of Padua.

Abstract:

:The purpose of this paper is to review the history of the clinico-pathologic investigations performed at the University of Padua on an old morbid entity ("parchment heart"), which, in the 1960s, led to the clinical description of the disease, in the 1980s to the revival of the scientific interest, and in the mid 1990s to the understanding of the genetic background. All the steps of the progressive knowledge are reviewed: necropsy of young people who died suddenly, in vivo diagnosis by ECG, echocardiography, angiocardiography, endomyocardial biopsy, nuclear magnetic resonance, and diagnostic criteria. Familial occurrence with autosomic dominant transmission and various penetrance was documented. Gene defects were recently mapped both to chromosome 14q23-q24 and 1q42-q43, thus providing evidence for genetic heterogeneity. The pathologic substrates of arrhythmogenic right ventricular cardiomyopathy pointed to an acquired progressive myocardial atrophy with fibro-fatty replacement of dying myocytes. Nowadays the disease is definitively regarded as a primary myocardial disorder and it has been included in the revised WHO classification of cardiomyopathies.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Basso C,Thiene G,Nava A,Dalla Volta S

doi

10.1002/clc.4960200406

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

333-6

issue

4

eissn

0160-9289

issn

1932-8737

journal_volume

20

pub_type

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