Abstract:
BACKGROUND:C-reactive protein (CRP) and myeloperoxidase (MPO) are involved in the pathogenesis of atherosclerosis, mainly during periods of instabilization. This study aims to test the hypothesis that patients with acute coronary syndrome (ACS) maintain a persistent inflammatory state, and that this is associated with long-term mortality. HYPOTHESIS:We hypothesized that serum C-reactive protein and myeloperoxidase collected at the index event and later, could add to the prognostic information in patients with ACS. METHODS:In a prospective cohort of 115 consecutive patients with ACS, myeloperoxidase and C-reactive protein were measured at admission and 2 y later. Patients were followed-up for the occurrence of cardiac death and other major cardiac events. RESULTS:Levels of CRP decreased from 26 +/- 34 mg/L in the acute phase to 6 +/- 8 mg/L in the chronic phase (p < 0.001), and MPO levels decreased from 86 +/- 43 pM to 27 +/- 32 pM (p < 0.001). After 29 +/- 12 mo, 27% patients died, 39% had new episode of ACS, and 30% underwent revascularization procedures. Initial CRP levels above 10 mg/L were associated with higher long-term mortality (hazard ratio [HR]: 2.43; 95% confidence interval [CI]: 0.98 to 6.07; p = 0.048). MPO levels were not associated with death or other major events. CONCLUSIONS:Changes over time or absolute values in the chronic phase of both markers were not associated with clinical outcomes. CRP levels, but not MPO levels, in the index event were predictive of long-term cardiovascular mortality.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Borges FK,Borges FK,Stella SF,Souza JF,Wendland AE,Werres Junior LC,Ribeiro JP,Polanczyk CAdoi
10.1002/clc.20462subject
Has Abstractpub_date
2009-11-01 00:00:00pages
E58-62issue
11eissn
0160-9289issn
1932-8737journal_volume
32pub_type
杂志文章abstract::Diabetes mellitus is a significant condition, affecting major segments of all population groups studied. With the introduction of insulin and oral hypoglycemic therapy, together with better understanding of diet and weight control gained over the past half century, the primary causes of diabetic morbidity and mortalit...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960121110
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:The optimal strategy for treating late presenters of ST-elevation myocardial infarction (STEMI) remains uncertain. HYPOTHESIS:percutaneous coronary intervention (PCI) has a favorable effect on left ventricular (LV) remodeling and clinical outcomes in late presenters of STEMI. METHODS:Patients with STEMI wh...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
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abstract::The purpose of the present study was to evaluate the effect of diltiazem on the left ventricular function in postinfarction patients. Twelve patients without cardiac decompensation at rest began diltiazem therapy beginning 3 months after an acute myocardial Q-wave infarction. Oral diltiazem was administered on the fir...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960111103
更新日期:1988-11-01 00:00:00
abstract::The prognosis for patients with non-Q-wave myocardial infarction (MI) remains controversial, although a number of studies have shown a less favorable outlook after hospital discharge for patients with non-Q-wave than for those with Q-wave infarction. Numerous management strategies are available to the clinician, many ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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更新日期:1989-07-01 00:00:00
abstract::A patient is presented who has mitral valve prolapse and syndactyly of the hands. This combination of findings has not been previously reported, but is consistent with one theory of the development of mitral valve prolapse. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960050306
更新日期:1982-03-01 00:00:00
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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doi:10.1002/clc.4960110910
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100911
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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doi:10.1002/clc.4960190208
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journal_title:Clinical cardiology
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doi:10.1002/clc.20351
更新日期:2009-04-01 00:00:00
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
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更新日期:2020-07-01 00:00:00