Abstract:
:The purpose of this study is to describe the use of angioscopes in flowing bloodstreams of animals and humans, to demonstrate the ability to precisely deliver laser energy to an intravascular target using visual guidance and to determine the information content and spatial content of angioscopy. Angioscopy was performed in 5 living dogs, 16 cadaver vascular segments, and 14 patients at the time of peripheral or coronary bypass surgery. Five canine femoral artery segments received angioscopically directed intravascular Nd:YAG laser irradiation. We were able to precisely direct the laser irradiation to predetermined intimal targets. Gross tissue injury varied from none to carbonization and vascular perforation, depending on incident energy. Using a variety of flexible fiberoptic endoscopes ranging in diameter from 1.5 to 3.7 mm, we were able to visualize intravascular structures including plaque, suture lines, venous valves, and thrombi in living patients. No patient incurred complications of any sort. We conclude that angioscopy using flexible endoscopes can be performed safely, can provide clinically useful information, and may provide a means for delivering visually directed intravascular laser irradiation.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Litvack F,Grundfest WS,Lee ME,Carroll RM,Foran R,Chaux A,Berci G,Rose HB,Matloff JM,Forrester JSdoi
10.1002/clc.4960080202subject
Has Abstractpub_date
1985-02-01 00:00:00pages
65-70issue
2eissn
0160-9289issn
1932-8737journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Advanced age remains one of the principal determinants of mortality in patients with acute myocardial infarction (AMI). HYPOTHESIS:The aim of this study was to determine the in-hospital outcome of elderly (> 75 years) patients with AMI who were admitted to hospitals participating in the national MITRA (Maxi...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960231109
更新日期:2000-11-01 00:00:00
abstract::Thrombotic obstruction of aortic bioprostheses is rare. Few cases have been reported involving the use of the Carpentier-Edwards (CE) prosthesis, the Hancock bioprosthesis, or the Medtronic Intact porcine valve. Thrombolytic therapy for mechanical valve thrombosis has been used frequently even though it is known to ca...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960160215
更新日期:1993-02-01 00:00:00
abstract::A 49-year-old female with significant (75%) left main coronary artery stenosis was initially considered to have developed early obstruction of a saphenous vein graft to the left anterior descending coronary artery, because of recurrent postoperative angina. In a second catheterization study, left ventriculography show...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100413
更新日期:1987-04-01 00:00:00
abstract::Pathophysiology of malignant hypertension, of which underlying disease was essential hypertension (EHT) in 33 cases and chronic glomerulonephritis (CGN) in 26 cases, was studied with reference to the renin-angiotensin system. Plasma renin activity (PRA) was significantly higher in the EHT than in the CGN group, and an...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100911
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Noncardiac organ failure has been associated with worse outcomes among a cardiac intensive care unit (CICU) population. HYPOTHESIS:We hypothesized that early organ failure based on the sequential organ failure assessment (SOFA) score would be associated with mortality in CICU patients. METHODS:Adult CICU p...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23339
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The right bundle branch block (RBBB) and the bifascicular blocks affect QRS duration in the right precordial leads, which are usually used for QT interval determination. Up to now, there is no clear recommendation how to determine QT interval in patients with RBBB or bifascicular block. HYPOTHESIS:The hypot...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23389
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Although suppression of premature ventricular contractions (PVCs) is not a predictor of mortality over the long term, the extent of PVC suppression is an important characteristic of any antiarrhythmic drug. HYPOTHESIS:This study was undertaken to determine whether intravenous (i.v.) dofetilide has the abili...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960230607
更新日期:2000-06-01 00:00:00
abstract::Many invasive and noninvasive methods have been used to study the cardiac atria; however, few allow quantitative measurement of atrial function. To determine the interaction between left ventricular (LV) contraction and left atrial (LA) filling, gated radionuclide angiography was conducted in 30 normal subjects (24 me...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170508
更新日期:1994-05-01 00:00:00
abstract::The use of neuroleptanalgesia in acute myocardial infarction offers the possibility of reducing pain and emotional stress. The influence of such treatment on hemodynamic parameters (heart rate, cardiac output, stroke volume, peripheral resistance, systemic blood pressure, and pulmonary pressure) and on the plasma leve...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960040505
更新日期:1981-09-01 00:00:00
abstract::The aim of this study was to assess whether drinking social amounts of alcohol impairs myocardial contractility in normal humans. To that end, 17 healthy volunteers performed isometric handgrip exercise before and 60 minutes after an intake of 1 g/kg body weight of ethanol within 60 minutes. Left ventricular M-mode ec...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960060302
更新日期:1983-03-01 00:00:00
abstract:BACKGROUNDS:The causes and prognosis of pericardial effusion (PE) may be different according to time, region, economy, and hospital. This study was performed to evaluate the etiology, clinical outcome, and prognosis of patients with large, symptomatic PE treated by echo-guided pericardiocentesis at Kangnam St. Mary's H...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20305
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Compared with medical therapy, percutaneous coronary intervention (PCI) does not reduce mortality or myocardial infarction in patients with stable angina. Therefore, PCI should be guided by refractory anginal symptoms and not just lesion characteristics. HYPOTHESIS:We hypothesized that angiographic lesion c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22510
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Due to chronic inflammatory status, rheumatoid arthritis (RA) patients are exposed to changes in left ventricular (LV) geometry and function. We assessed prevalence, factors associated with, and prognostic role of concentric LV geometry and systolic dysfunction (LVSD) detected by echocardiography in a large ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22926
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:Genetic influence on development of athlete's heart is uncertain. This study investigated whether angiotensin-converting enzyme (ACE) gene polymorphism influenced development of athlete's heart. METHODS:Forty-three participants in a 100-km ultramarathon were classified on the basis of ACE gen...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960230814
更新日期:2000-08-01 00:00:00
abstract::Cellular interactions between leukocytes and the endothelium are critical events in vascular biology, such as atherosclerosis and acute coronary syndrome. When monocytes and endothelial cells are activated via direct cell-cell interaction, both types of cells express several biologically active molecules such as adhes...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960210103
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The incidence of congestive heart failure (CHF) has not significantly declined over the past 50 years, and overall survival rates are low at 5 years following diagnosis. Numerous studies have shown low serum sodium to be a poor prognostic indicator of all cause mortality in CHF patients. HYPOTHESIS:The goal...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20560
更新日期:2010-12-01 00:00:00
abstract::This review examines the issue of preoperative cardiac evaluation from a critical point of view, based on recent medical literature. We reviewed the history of that field and focused on the American College of Cardiology and American Heart Association guidelines, which are a cornerstone in the field of cardiac patient...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960290505
更新日期:2006-05-01 00:00:00
abstract::Cusp entrapment is a previously unreported mechanism of aortic insufficiency after balloon aortic valvuloplasty. In a patient who developed severe acute aortic insufficiency and expired after balloon aortic valvuloplasty, pathologic evaluation revealed a large, solitary, fractured, calcific nodule in the noncoronary c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120711
更新日期:1989-07-01 00:00:00
abstract::In the last 15 years, intense interest has focused on various interventional, pharmacologic, and mechanical forms of therapy for the treatment of atherosclerotic coronary artery disease. Many techniques and devices (dilating balloons, perfusion catheters, thermal probes and balloons, lasers, atherectomy devices, stent...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960150812
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Ventricular arrhythmias are the most common consequences of structural and functional heart diseases, but cases with no evident pathology are also observed. A parameter indicating asymptomatic circulatory failure could support decisions related to possible treatment of ventricular arrhythmias. HYPOTHESIS:Th...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20611
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Congestive heart failure is the most common cause of mortality in patients with end-stage renal disease (ESRD). However, noninvasive assessment for cardiac involvement in ESRD has not been established. HYPOTHESIS:Assessment of ultrasonic tissue characterization and serum markers of collagen degradation is u...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270412
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) readmission rates have become an increasingly important quality metric since the advent of the Hospital Readmissions Reduction Program. Despite many well-intentioned efforts to reduce readmissions, clinicians continue to struggle with the problem of high HF readmission rates. HYPOTHESIS:H...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22738
更新日期:2017-10-01 00:00:00
abstract::During the last several years dilating balloons have been applied in the treatment of stenotic cardiac valves. This interest has been extended to stenotic porcine bioprosthetic valves. Part I of this review discusses the pathologic changes producing stenotic porcine prosthetic valves. Part II of this review describes ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960140912
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Troponin I (TnI) is increasingly employed as a highly specific marker of acute myocardial ischemia. The value of this marker after cardiac surgery is unclear. HYPOTHESIS:The purpose of this study was to measure serum TnI levels prospectively at 1, 6, and 72 h after elective cardiac operations. In addition, ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960231009
更新日期:2000-10-01 00:00:00
abstract::In the past, many have avoided nuts because of their high fat content. The Dietary Approaches to Stop Hypertension (DASH) diet, however, recommends regular consumption of this food along with seeds and dried beans (4-5 servings per week) as part of a diet to control hypertension. Nuts are nutrient-dense and most of th...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960221504
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Preventive cardiology is currently not an American Board of Medical Specialties-recognized subspecialty. However, several programs offer non-accredited fellowships throughout the country. No source currently exists listing all available programs, and finding programs requires time-intensive search strategies...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.21959
更新日期:2012-05-01 00:00:00
abstract::Arrhythmogenic right ventricular dysplasia (ARVD) is a rare cardiomyopathy characterized by the progressive replacement of cardiomyocytes by fatty and fibrous tissue in the right ventricle (RV). These infiltrations lead to cardiac electrical instability and ventricular arrhythmia. Current treatment for ARVD is empiric...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.22884
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:Some previous studies have suggested a high prevalence of pulmonary embolism (PE) during exacerbations of chronic obstructive pulmonary disease (ECOPD). The SLICE trial aims to assess the efficacy and safety of an active strategy for the diagnosis and treatment of PE (vs usual care) in patients hospitalize...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23161
更新日期:2019-03-01 00:00:00
abstract::Within 3 h after the onset of symptoms of myocardial infarction, 64 patients were randomly assigned to receive either a 1-h intravenous infusion of 1,500,000 IU of streptokinase (SK) or a conventional therapy. Infarct size was estimated in CK gram equivalent (CKg) by measurement of CK-MB every 3 hours during a 48-h pe...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960100704
更新日期:1987-07-01 00:00:00
abstract::Recent clinical investigations have provided new insights into physiologic alterations taking place as heart failure progresses. As a result, new end points may be more relevant to monitor in patients, rather than the classical assessment of severity based on subjective evaluation of functional capacity. Structural ch...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960181603
更新日期:1995-09-01 00:00:00