Effect of left ventricular contractile performance on passive left atrial filling--clinical study using radionuclide angiography.

Abstract:

:Many invasive and noninvasive methods have been used to study the cardiac atria; however, few allow quantitative measurement of atrial function. To determine the interaction between left ventricular (LV) contraction and left atrial (LA) filling, gated radionuclide angiography was conducted in 30 normal subjects (24 men and 6 women, mean age 58 +/- 10 years, range 26-68). LV and LA time-activity curves and their first-derivative curves were obtained simultaneously by using the method of Bough et al. The LV ejection fraction (64 +/- 18%) and LV peak ejection rate (LVPER; 3.42 +/- 0.27 EDV/s) were computed from these curves. As indices of LA filling, LA fractional emptying (38 +/- 12%) and LA peak filling rate (LAPFR; 2.86 +/- 0.17 LAVmax/s)--the latter being defined as the peak rate of LA filling during the LA filling phase--were also computed from these curves. In all subjects, the timing of the LVPER coincided with the occurrence of LAPFR, and there was a significant positive correlation between the LVPER and LAPFR (r = 0.81, p < 0.001), indicating that the LAPFR was strongly affected by the degree of LVPER. Thus, these results indicate that LV contractile performance plays an important role in determining LA passive filling during ventricular systole.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Fujii K,Ozaki M,Yamagishi T,Ishine K,Furutani Y,Nagano H,Yamamoto K,Saiki A,Matsuzaki M

doi

10.1002/clc.4960170508

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

258-62

issue

5

eissn

0160-9289

issn

1932-8737

journal_volume

17

pub_type

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