Effect of left ventricular contractile performance on passive left atrial filling--clinical study using radionuclide angiography.


:Many invasive and noninvasive methods have been used to study the cardiac atria; however, few allow quantitative measurement of atrial function. To determine the interaction between left ventricular (LV) contraction and left atrial (LA) filling, gated radionuclide angiography was conducted in 30 normal subjects (24 men and 6 women, mean age 58 +/- 10 years, range 26-68). LV and LA time-activity curves and their first-derivative curves were obtained simultaneously by using the method of Bough et al. The LV ejection fraction (64 +/- 18%) and LV peak ejection rate (LVPER; 3.42 +/- 0.27 EDV/s) were computed from these curves. As indices of LA filling, LA fractional emptying (38 +/- 12%) and LA peak filling rate (LAPFR; 2.86 +/- 0.17 LAVmax/s)--the latter being defined as the peak rate of LA filling during the LA filling phase--were also computed from these curves. In all subjects, the timing of the LVPER coincided with the occurrence of LAPFR, and there was a significant positive correlation between the LVPER and LAPFR (r = 0.81, p < 0.001), indicating that the LAPFR was strongly affected by the degree of LVPER. Thus, these results indicate that LV contractile performance plays an important role in determining LA passive filling during ventricular systole.


Clin Cardiol


Clinical cardiology


Fujii K,Ozaki M,Yamagishi T,Ishine K,Furutani Y,Nagano H,Yamamoto K,Saiki A,Matsuzaki M




Has Abstract


1994-05-01 00:00:00












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    journal_title:Clinical cardiology

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    authors: Fujita M,Nakae I,Kihara Y,Hasegawa K,Nohara R,Ueda K,Tamaki S,Otsuka K,Sasayama S

    更新日期:1999-09-01 00:00:00

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    authors: Cioffi G,Ognibeni F,Dalbeni A,Giollo A,Orsolini G,Gatti D,Rossini M,Viapiana O

    更新日期:2018-06-01 00:00:00

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    更新日期:1986-05-01 00:00:00

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    更新日期:2002-11-01 00:00:00

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    更新日期:1997-06-01 00:00:00

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    更新日期:1990-09-01 00:00:00

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    更新日期:1995-04-01 00:00:00

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    authors: Novak G,Kross K,Follmer K,Brofferio A,Shirani J

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    journal_title:Clinical cardiology

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    authors: Kautzner J,Bĕlohlávek M,Holm FV,Munclinger MJ

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    authors: Rafferty T,Edwards B,Judd J,Swamy V,Workman R,Lippmann H,Harris S,Cohen I,Prokop E,Ezekowitz M

    更新日期:1993-10-01 00:00:00

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    abstract::Antihypertensive drug therapy can lower blood pressure and prolong life, but many hypertensive patients continue to develop further risk factors and to die prematurely of heart disease. Antihypertensive drugs can also interfere with the patient's quality of life, and many are not compatible with the concomitant medica...

    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Itskovitz HD

    更新日期:1995-06-01 00:00:00

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    journal_title:Clinical cardiology

    pub_type: 杂志文章


    authors: Ogawa S,Mardelli TJ,Hubbard FE

    更新日期:1978-08-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Gupta P,Robertson MJ,Beam BW,Rettiganti M

    更新日期:2015-02-01 00:00:00