Blockade of the renin-angiotensin-aldosterone system in patients with arrhythmogenic right ventricular dysplasia: A double-blind, multicenter, prospective, randomized, genotype-driven study (BRAVE study).

abstract：BACKGROUND:Cibenzoline, a class Ia antiarrhythmic drug, can be used to relieve left ventricular (LV) outflow obstruction in hypertrophic obstructive cardiomyopathy (HOCM). However, the mechanism of this agent in HOCM has been controversial. HYPOTHESIS:This study was designed to investigate the effect of cibenzoline on...

journal_title：Clinical cardiology

authors： Kondo I,Mizushige K,Nozaki S,Hirao K,Iwado Y,Ohmori K,Matsuo H

更新日期：2000-09-01 00:00:00

abstract：:Mitral anulus calcification (MAC) and mitral valve prolapse (MVP) are frequently diagnosed conditions. We studied two patients with mild or moderate mitral regurgitation who demonstrated both MAC and MVP on angiography and echocardiography. M-mode echocardiography is probably the definitive test for confirming the pre...

journal_title：Clinical cardiology

authors： McLean J,Felner JM,Whipple R,Morris D,Schlant RC

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:Until now there were no clinical studies or systematic reviews to investigate the impact of timing on efficacy and safety of intracoronary bone marrow stem cell (BMSC) transfer in patients with acute myocardial infarction (AMI). HYPOTHESIS:Timing of BMSC administration might play an important role in the th...

journal_title：Clinical cardiology

authors： Zhang S,Sun A,Xu D,Yao K,Huang Z,Jin H,Wang K,Zou Y,Ge J

更新日期：2009-08-01 00:00:00

abstract：:Fourteen morbidly obese patients scheduled for gastric bypass surgery were diagnosed preoperatively as suffering from sleep apnea syndrome. There were 13 males and 1 female aged 24 to 59 years. Mean preoperative excessive body weight was 222 +/- 38%; mean apnea index prior to surgery was 84 +/- 44. A whole night lead ...

journal_title：Clinical cardiology

authors： Peiser J,Ovnat A,Uwyyed K,Lavie P,Charuzi I

更新日期：1985-10-01 00:00:00

abstract：:As I advanced through medical school at Johns Hopkins, and throughout my subsequent training, I was constantly reminded of the contributions made to medicine by our predecessors. Many of whom were at Johns Hopkins, but many were not. As I continue active involvement in the education of medical students and physicians,...

journal_title：Clinical cardiology

authors： Conti CR

更新日期：2008-04-01 00:00:00

abstract：:In addition to the role of the electrophysiological substrate, paroxysmal atrial fibrillation depends on the modulation of the atrial tissues by the autonomic nervous system. Experimentally, models of atrial fibrillation can be based on either adrenergic or vagal stimulations that provoke the arrhythmia by disturbing ...

journal_title：Clinical cardiology

authors： Coumel P

更新日期：1990-03-01 00:00:00

abstract：:During myocardial ischemia, fatty acids are the principal source of energy, increasing myocardial oxygen consumption and making a decrease in coronary blood flow less well tolerated. Increasing glucose oxidation during myocardial ischemia may improve cardiac efficiency. The pFOX inhibitors have the potential to accomp...

journal_title：Clinical cardiology

authors： Conti CR

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:For decades, fasting for 8 to 12 hours has been recommended for measurement of lipid profiles. The effect of fasting on low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) has been described in healthy cohorts and those with stable disease states. Recently, guidelines suggested that fasting ma...

journal_title：Clinical cardiology

authors： Steen DL,Umez-Eronini AA,Guo J,Khan N,Cannon CP

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Rarely occurring in the pediatric and adolescent population, aortic dissection is a condition with many predisposing factors. Previous studies have suggested that congenital cardiovascular disorders are the most common predisposing conditions. Trauma-associated aortic dissection is considered a rare occurren...

journal_title：Clinical cardiology

authors： Fikar CR,Fikar R

更新日期：2009-06-01 00:00:00

abstract：:Flecainide is reported to be effective in patients with paroxysmal tachycardias, but its effect on rapid ventricular response over accessory atrioventricular pathway during atrial fibrillation is not known. The influence of flecainide on various electrophysiological properties of the accessory pathway with special emp...

journal_title：Clinical cardiology

authors： Kappenberger LJ,Fromer MA,Shenasa M,Gloor HO

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Chronic heart failure (CHF) is associated with an increased risk of thrombosis and thromboembolic events, including stroke and venous thromboembolism. which may be related to a prothrombotic or hypercoagulable state. Acute vigorous exercise has been associated with activation of hemostasis, and this risk may...

journal_title：Clinical cardiology

authors： Gibbs CR,Blann AD,Edmunds E,Watson RD,Lip GY

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Syncope is a common clinical problem with a variety of underlying mechanisms, some of which occur more frequently in 1 of the sexes or at a certain age. HYPOTHESIS:There may be clinically significant age- and gender-related differences in patients with unexplained syncope. METHODS:Five hundred seventy pati...

journal_title：Clinical cardiology

authors： Edvardsson N,Garutti C,Rieger G,Linker NJ,PICTURE Study Investigators.

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Marfan's syndrome is an inherited disorder of connective tissue associated with characteristic abnormalities of the skeletal, ocular, and cardiovascular systems. Marked clinical variability and age dependency of all manifestations of Marfan's syndrome may render the unequivocal diagnosis difficult in mildly ...

journal_title：Clinical cardiology

authors： Mercuro G,Carpiniello B,Ruscazio M,Zoncu S,Montisci R,Rudas N,Cherchi A

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:There is a growing body of evidence that advanced glycation end products (AGE) and their receptor (RAGE) system are implicated in chronic kidney disease (CKD). We have previously found that a long-acting calcium channel blocker, azelnidipine, but not amlodipine, improves renal injury in CKD patients. However...

journal_title：Clinical cardiology

authors： Nakamura T,Sato E,Fujiwara N,Kawagoe Y,Koide H,Ueda Y,Takeuchi M,Yamagishi S

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Left ventricular hypertrophy (LVH) on the electrocardiogram (ECG) may be masked in the presence of complete right bundle-branch block (RBBB). Left bundle-branch block on the ECG is associated with LVH at autopsy in 93% of hearts studied. However, RBBB does not predict LVH and the usual ECG criteria applied f...

journal_title：Clinical cardiology

authors： Mehta A,Jain AC,Morise AP,Mehta MC,Billie M

更新日期：1998-02-01 00:00:00

abstract：:Noninvasive determination of left-side intracardiac pressures is of clinical importance in many cardiac diseases. To test the reliability and accuracy of left-side intracardiac pressure measurements by continuous-wave Doppler echocardiography, using left-side valvular regurgitations, 47 patients with mitral regurgitat...

journal_title：Clinical cardiology

authors： Ge ZM,Zhang Y,Fan DS,Zhang M,Fan JX,Zhao YX

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Management of acute coronary syndrome (ACS) patients with nonobstructive epicardial coronary artery disease (CAD) remains poorly understood. HYPOTHESIS:Acute coronary syndrome patients with nonobstructive CAD are less likely to receive effective cardiac medications upon discharge from the hospital. METHODS...

journal_title：Clinical cardiology

authors： Ramanath VS,Armstrong DF,Grzybowski M,Rahnama-Mohagdam S,Tamhane UU,Gordon K,Froehlich JB,Eagle KA,Jackson EA

更新日期：2010-01-01 00:00:00

abstract：:A patient with severe pulmonary hypertension secondary to the CREST syndrome variant of scleroderma is described. Acute reductions in both pulmonary artery pressure and total pulmonary resistance were seen with nifedipine and oxygen administration. Reductions in resistance were maintained for over one month with this ...

journal_title：Clinical cardiology

authors： Morrison D,Goldman S,Alepa FP

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Although women typically develop coronary artery disease several years after men, once they have symptomatic disease their thromboembolic complications are worse than in men. The mechanism mediating this gender difference in outcome after thromboembolic events is unknown. We previously studied platelet funct...

journal_title：Clinical cardiology

authors： Goldschmidt-Clermont PJ,Schulman SP,Bray PF,Chandra NC,Grigoryev D,Dise KR,Sagar M,Fox RJ,Coleman LD,Richardson C,Dorsey FC,du Mee C,Kitt MM,Ouyang P,Baughman KL,Gerstenblith G

更新日期：1996-11-01 00:00:00

abstract：:A 55-year-old Caucasian woman suddenly developed substernal chest pain at rest accompanied by pallor, diaphoresis, nausea, and vomiting. Physical examination was otherwise unremarkable. The resting ECG showed T-wave inversion in all anterior leads which returned to normal 24 h after the onset of the symptoms. The pain...

journal_title：Clinical cardiology

authors： Bestetti RB,Finzi LA,Oliveira JS

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Identifying vulnerable plaque is important for preventing an acute coronary event. The present study examined the relationship between the clinical presentation of coronary artery disease and the plaque characteristics of nonculprit segment assessed by virtual histology intravascular ultrasound (VH-IVUS). M...

journal_title：Clinical cardiology

authors： Nakamura T,Kubo N,Funayama H,Sugawara Y,Ako J,Momomura S

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Although sudden death (SD) is a rare complication after atrioventricular junction (AVJ) ablation and permanent pacemaker implantation, the risk factors leading to this SD remain unknown. The purpose of this study was to investigate SD and its risk factors after ablate-and-pace strategy for rate control in at...

journal_title：Clinical cardiology

authors： Wang RX,Lee HC,Li JP,Hodge DO,Cha YM,Friedman PA,Munger TM,Srivathsan K,Pavri BB,Shen WK

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the influence of atrial fibrillation (AF) on the immediate and long-term outcome of patients undergoing balloon mitral valvotomy (BMV). HYPOTHESIS:Patients with atrial fibrillation fair poorly after balloon mitral valvotomy. METHODS:There were a total of 818 consecu...

journal_title：Clinical cardiology

authors： Nair KK,Pillai HS,Thajudeen A,Krishnamoorthy KM,Sivasubramonian S,Namboodiri N,Sasidharan B,Ganapathy S,Varaparambil A,Titus T,Tharakan J

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Left ventricular ejection fraction (LVEF) has shown to predict outcomes in patients with heart failure (HF). Left ventricular recovery (LVR) has shown to improve prognosis. HYPOTHESIS:Guideline-directed medical therapy will predict LVR in patients with HF and reduced LVEF. METHODS:We studied 244 patients w...

journal_title：Clinical cardiology

authors： Valika A,Paprockas K,Villines D,Costanzo MR

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND HYPOTHESIS:Previous research has failed to document temporal changes in epinephrine levels in patients with neurally mediated syncope associated with exercise. The purpose of this study was to investigate the role of circulatory catecholamines in exercise-induced neurally mediated syncope, specifically f...

journal_title：Clinical cardiology

authors： Takase B,Kastushika S,Hamabe A,Uehata A,Isojima K,Satomura K,Nishioka T,Ohsuzu F,Kurita A

更新日期：2001-01-01 00:00:00

abstract：:Subaortic stenosis has been described with increasing frequency as an ominous feature of atrioventricular septal defect (AVSD), especially following surgical correction of the anomaly in non-Down's syndrome patients. In order to study the surgical anatomy of the left ventricular outflow tract in this malformation, 48 ...

journal_title：Clinical cardiology

authors： Gallo P,Formigari R,Hokayem NJ,D'Offizi F,D'Alessandro,Francalanci P,d'Amati G,Colloridi V,Pizzuto F

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:The presence or absence of collateral circulation to the infarct-related coronary artery in acute myocardial infarction (AMI) significantly impacts on infarct size and resulting left ventricular function. However, the determinants of collateral development have not been clarified. HYPOTHESIS:The purpose of ...

journal_title：Clinical cardiology

authors： Fujita M,Nakae I,Kihara Y,Hasegawa K,Nohara R,Ueda K,Tamaki S,Otsuka K,Sasayama S

更新日期：1999-09-01 00:00:00

abstract：:Many invasive and noninvasive methods have been used to study the cardiac atria; however, few allow quantitative measurement of atrial function. To determine the interaction between left ventricular (LV) contraction and left atrial (LA) filling, gated radionuclide angiography was conducted in 30 normal subjects (24 me...

journal_title：Clinical cardiology

authors： Fujii K,Ozaki M,Yamagishi T,Ishine K,Furutani Y,Nagano H,Yamamoto K,Saiki A,Matsuzaki M

更新日期：1994-05-01 00:00:00

abstract：:K-strophanthin or digoxin were added to diuretics (all cases) and vasodilators (most cases) for treating advanced congestive heart failure in 22 patients with dilated cardiomyopathy and sinus rhythm. K-strophanthin (0.125 mg intravenously) or digoxin (0.25 mg orally) were administered daily in two 3-month periods, dur...

journal_title：Clinical cardiology

authors： Agostoni PG,Doria E,Berti M,Guazzi MD

更新日期：1994-10-01 00:00:00

abstract：:The success of percutaneous transluminal coronary angioplasty is limited by acute occlusion and late restenosis. In 25 patients (20 men, 5 women, age range 36-81 years) coronary angioplasty was performed using a new cutting balloon into which 3-4 longitudinally orientated blades are incorporated so as to reduce the ra...

journal_title：Clinical cardiology

authors： Unterberg C,Buchwald AB,Barath P,Schmidt T,Kreuzer H,Wiegand V

更新日期：1993-09-01 00:00:00