Abstract:
:Flecainide is reported to be effective in patients with paroxysmal tachycardias, but its effect on rapid ventricular response over accessory atrioventricular pathway during atrial fibrillation is not known. The influence of flecainide on various electrophysiological properties of the accessory pathway with special emphasis on ventricular rate during atrial fibrillation was investigated in 9 patients with severe symptomatic Wolff-Parkinson-White syndrome. The shortest ventricular response during atrial fibrillation increased from 218 (190-270) to 320 (240-block) ms. In 4 patients sustained rapid atrial fibrillation converted to sinus rhythm. The rate of circus movement tachycardia decreased from 166/min to 130/min after flecainide, due to a lengthening of retrograde ventriculoatrial conduction time over the accessory pathway. Flecainide caused a significant prolongation of the effective refractory period of the accessory pathway in our subgroup with extremely fast AV conduction during atrial fibrillation and induced a depressant effect on retrograde accessory pathway conduction. This makes the drug very promising for the emergency treatment of dangerous rapid tachyarrhythias complicating this syndrome.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Kappenberger LJ,Fromer MA,Shenasa M,Gloor HOdoi
10.1002/clc.4960080603subject
Has Abstractpub_date
1985-06-01 00:00:00pages
321-6issue
6eissn
0160-9289issn
1932-8737journal_volume
8pub_type
杂志文章abstract::Fourteen morbidly obese patients scheduled for gastric bypass surgery were diagnosed preoperatively as suffering from sleep apnea syndrome. There were 13 males and 1 female aged 24 to 59 years. Mean preoperative excessive body weight was 222 +/- 38%; mean apnea index prior to surgery was 84 +/- 44. A whole night lead ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960081005
更新日期:1985-10-01 00:00:00
abstract::There is an apparent benefit with extension of dual antiplatelet therapy (DAPT) beyond 1 year after implantation of drug-eluting stents (DES). Assessment by a Double Randomization of a Conventional Antiplatelet Strategy vs a Monitoring-Guided Strategy for Drug-Eluting Stent Implantation, and of Treatment Interruption ...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.22512
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Preventive cardiology is currently not an American Board of Medical Specialties-recognized subspecialty. However, several programs offer non-accredited fellowships throughout the country. No source currently exists listing all available programs, and finding programs requires time-intensive search strategies...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.21959
更新日期:2012-05-01 00:00:00
abstract::Recent investigations have indicated that chronic heart failure can be reversed with agents that inhibit the reninangiotensin-aldosterone or sympathetic nervous system, such as angiontensin-converting enzyme (ACE) inhibitors and beta blockers. A meta-analysis of clinical trials of ACE inhibition in chronic heart failu...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Evaluation of chest pain accounts for millions of costly Emergency Department (ED) visits and hospital admissions annually. Of these, approximately 10-20% are myocardial infarctions (MI). HYPOTHESIS:Patients with chest pain whose initial electrocardiogram (ECG) is normal do not require hospital admission fo...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20141
更新日期:2007-11-01 00:00:00
abstract::Coronary artery disease (CAD) is still the number-one killer in the world, and clinical trials indicate that it is preventable. Mortality and morbidity can be reduced by at least 30% to 40% by treating known risk factors. Genetic susceptibility is claimed to account for 50% of predisposition. The challenge of preventi...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22002
更新日期:2012-09-01 00:00:00
abstract::It has been debated whether dilated cardiomyopathy seen in patients with acquired immune deficiency syndrome is caused by the virus itself or by the combination of other factors such as presence of opportunistic pathogens and/or severe immunosuppression. This paper describes the first reported case of a patient with h...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960200815
更新日期:1997-08-01 00:00:00
abstract::Hyponatremia is common and is increasingly recognized as an independent prognostic marker that adversely affects morbidity and mortality in various disease states, including heart failure. In acute decompensated heart failure (ADHF), the degree of hyponatremia often parallels the severity of cardiac dysfunction and is...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20822
更新日期:2010-11-01 00:00:00
abstract::Recommendations in the 2007 update of the American College of Cardiology/American Heart Association guidelines for patients with non-ST-elevation myocardial infarction (NSTEMI) provide considerable latitude regarding treatment choices and care pathways. Nevertheless, as accumulating evidence leads to increased recomme...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20671
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Radiation-treated head and neck cancer (HNC) patients are at high risk for developing radiation vasculopathy, as evidenced by an increased stroke risk. The benefits of screening and assessing the cardiovascular (CV) risk of HNC patients using carotid intima-media thickness (CIMT) ultrasound are not known. Ou...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22389
更新日期:2015-05-01 00:00:00
abstract::Adenosine triphosphate (ATP) and adenosine exert strong and transient depressant effects on the sinoatrial and atrioventricular (AV) nodes of the human heart. The AV nodal effects of these drugs explain their high efficacy in either terminating AV re-entrant supraventricular tachycardia or in slowing ventricular rate ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960080903
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Although suppression of premature ventricular contractions (PVCs) is not a predictor of mortality over the long term, the extent of PVC suppression is an important characteristic of any antiarrhythmic drug. HYPOTHESIS:This study was undertaken to determine whether intravenous (i.v.) dofetilide has the abili...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960230607
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Although ischemic threshold reportedly is lower in the early morning than in the afternoon, the mechanisms that account for the diurnal change in minimal coronary vascular resistance in the potentially ischemic area are unknown. HYPOTHESIS:We hypothesized that calcium-channel blockers and alpha 1 blockers m...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960210512
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Vasovagal syncope (VVS) is a common cause of recurrent syncope. Nevertheless, the exact hemodynamic mechanism has not been elucidated. Pulse wave analysis (PWA) is widely used to evaluate vascular properties, as it reflects the condition of the entire arterial system. HYPOTHESIS:Cardiovascular autonomic mod...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23380
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Carotid artery stenting (CAS) is increasingly used for treatment of severe carotid artery stenosis, but only few procedural risk factors for complications of CAS are clearly defined yet. A possible impact of the patient's gender on the outcome of patients undergoing CAS has not been investigated properly and...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.21015
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Most antiarrhythmic interventional therapies for atrial fibrillation (AF) have been provided with special focus on the treatment of left-sided valvular disease and enlarged left atrium but few studies have assessed AF associated with congenital heart disease and dilated right atrium. HYPOTHESIS:We hypothesi...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23051
更新日期:2018-10-01 00:00:00
abstract::Several investigators have documented the successful use of oral sustained-release theophylline in treating symptomatic bradycardia and sick sinus syndrome. This paper reports a case of chronotropic incompetence in which specific exercise indices, including the chronotropic response index, were used to measure the the...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,评审
doi:10.1002/clc.4960231019
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:The present European guidelines suggest a diagnostic electrophysiological (EP) study to determine indication for cardiac pacing in patients with bundle branch block and unexplained syncope. We evaluated the prognostic relevance of an EP study for mortality and the development of permanent complete atrioventr...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22700
更新日期:2017-08-01 00:00:00
abstract::We reviewed our experience with the diagnosis of cardiac myxoma in 10 patients seen between 1960 and 1981. At surgery, large myxomas (greater than 5 cm) were found in the left atrium in 6 patients, right atrium in 3, and right ventricle in 1. The correct preoperative diagnosis was made in 9 patients: clinically in 3 a...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960061008
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:Randomized controlled trials showed the nonvitamin K oral anticoagulant (NOAC) edoxaban was effective and safe for stroke and systemic embolism prevention in nonvalvular atrial fibrillation (AF) and for the prevention and treatment of venous thromboembolism (VTE; including pulmonary embolism and deep vein th...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23279
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Iodine-123 metaiodobenzylguanidine (123I-MIBG) concentrates in adrenergic neurons and has been developed for evaluation of the sympathetic nervous system. Recent studies have demonstrated that the normal heart is clearly visualized by 123I-MIBG cardiac scintigraphy, whereas abnormal 123I-MIBG myocardial upta...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960200113
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:QT interval shortens with exercise. Some of this shortening is due to an increase in heart rate, and some is due to other effects of exercise, probably mostly neuroendocrine effects. Data from subjects with cardiac transplants have suggested that non-heart rate-related changes in QT interval on exercise are ...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960220805
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Therapeutic hypothermia improves survival for selected patients who remain comatose after cardiac arrest. Hypothermia triggers changes in electrocardiographic (ECG) parameters; however, the association of these changes to in-hospital mortality remains unclear. HYPOTHESIS:QT interval changes induced by thera...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22224
更新日期:2014-02-01 00:00:00
abstract::Lithium has been used for the treatment of bipolar disorder for more than 6 decades. Reports of cardiac side effects resulting in both benign electrocardiographic (ECG) changes and near fatal arrhythmias have been reported in the literature. A systematic literature search was conducted on 2 electronic databases-PubMed...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22822
更新日期:2017-12-01 00:00:00
abstract::The AFFIRM study showed no clear survival advantage for a rhythm versus rate control strategy in patients with atrial fibrillation (AF). However, rhythm control with antiarrhythmic drugs (AADs) is appropriate in a large number of patients with AF. The American College of Cardiology/ American Heart Association/European...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960290303
更新日期:2006-03-01 00:00:00
abstract::Most series of patients with ventricular tachycardia (VT) of right bundle-branch block (RBBB)-left axis deviation (LAD) morphology include young individuals with no overt evidence of structural heart disease. In the present report, the clinical and electrophysiologic findings in two patients with verapamil-responsive ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960150617
更新日期:1992-06-01 00:00:00
abstract::Recently, a debate over the merits of statin therapy in primary prevention was published in the Wall Street Journal. The statin opponent claimed that statins should only be used in secondary prevention and never in any primary-prevention patients at risk for cardiovascular events. In this evidence-based rebuttal to th...
journal_title:Clinical cardiology
pub_type: 社论,评审
doi:10.1002/clc.22016
更新日期:2012-01-01 00:00:00
abstract::In order to assess the diagnostic value of dipyridamole (D) testing, we studied the responses of 34 patients with chest pain and 10 normal subjects. Blood pressure and 12-lead ECG were recorded during and after intravenous infusion of 0.6 mg/kg dipyridamole for 10 minutes. Coronary arteriography and maximal or symptom...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960050402
更新日期:1982-04-01 00:00:00
abstract::Aspirin is integral in the primary and secondary prevention of coronary artery disease and acute coronary syndrome. Given the high clinical importance of aspirin in the management of coronary artery disease, much attention has been directed towards the concept of "aspirin resistance." Unfortunately, the term aspirin r...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22031
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Marfan's syndrome is an inherited disorder of connective tissue associated with characteristic abnormalities of the skeletal, ocular, and cardiovascular systems. Marked clinical variability and age dependency of all manifestations of Marfan's syndrome may render the unequivocal diagnosis difficult in mildly ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960200311
更新日期:1997-03-01 00:00:00