Abstract:
BACKGROUND:QT interval shortens with exercise. Some of this shortening is due to an increase in heart rate, and some is due to other effects of exercise, probably mostly neuroendocrine effects. Data from subjects with cardiac transplants have suggested that non-heart rate-related changes in QT interval on exercise are due to the effects of circulating catecholamines. HYPOTHESIS:We sought to determine whether changes in plasma catecholamine levels with exercise are an important contributor to non-heart rate-related QT interval shortening. METHODS:Subjects with DDD pacemakers were recruited. Subjects had QT intervals measured at rest, during a low fixed level exercise test designed to increase heart rate to about 110 beats/min, and, after resting, during pacing at a heart rate of 110 beats/min. Catecholamine levels were measured at each stage of the study. RESULTS:QT interval at rest was 420 +/- 12 ms, during pacing 366 +/- 16 ms, and on exercise 325 +/- 14 ms. This then gave the proportion of QT interval shortening due to heart rate as 68.6 +/- 9.3% of total QT shortening, with the range between 35 and 95.6%. There was no proportionality between the degree of QT interval shortening on exercise that was not due to increases in heart rate and changes in plasma catecholamine levels. CONCLUSION:Two-thirds of exercise-induced QT interval shortening are due to an increase in heart rate, and one-third to other effects. Changes in plasma catecholamine levels on exercise were not closely related to changes in the QT interval on exercise.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Davey P,Bateman Jdoi
10.1002/clc.4960220805subject
Has Abstractpub_date
1999-08-01 00:00:00pages
513-8issue
8eissn
0160-9289issn
1932-8737journal_volume
22pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Apixaban is a non-vitamin K oral anticoagulant approved for prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF). Current labeling recommends dose reduction based on patient age, weight, and renal function. HYPOTHESIS:The aim of this study was to analyze adherence...
journal_title:Clinical cardiology
pub_type: 杂志文章
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,评审
doi:10.1002/clc.4960120503
更新日期:1989-05-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960161012
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960080603
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abstract::In a family affected by arrhythmogenic right ventricular cardiomyopathy (ARVC) the familial occurrence was investigated. All 14 members of two generations were investigated carefully, and only 2 (father and one son) members were affected. Both subjects had a massive form of the disease with relevant ventricular arrhyt...
journal_title:Clinical cardiology
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更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/clc.4960190316
更新日期:1996-03-01 00:00:00
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journal_title:Clinical cardiology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
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更新日期:2013-07-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1002/clc.4960131310
更新日期:1990-03-01 00:00:00
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更新日期:2010-12-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090710
更新日期:1986-07-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110402
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journal_title:Clinical cardiology
pub_type: 杂志文章
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更新日期:1984-10-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/clc.20171
更新日期:2007-08-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960150104
更新日期:1992-01-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22
更新日期:2006-12-01 00:00:00
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doi:10.1002/clc.4960190208
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960161206
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pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00