Cannabinoids and atherosclerotic coronary heart disease.

Abstract:

:Marijuana is the most abused recreational drug in the United States. Cannabinoids, the active ingredients of marijuana, affect multiple organ systems in the human body. The pharmacologic effects of marijuana, based on stimulation of cannabinoid receptors CB1 and CB2, which are widely distributed in the cardiovascular system, have been well described. Activation of these receptors modulates the function of various cellular elements of the vessel wall, and may contribute to the pathogenesis of atherosclerosis. Clinically, there are reports linking marijuana smoking to the precipitation of angina and acute coronary syndromes. Recently, large published clinical trials with CB1 antagonist rimonabant did not show any significant benefit of this agent in preventing progression of atherosclerosis. In light of these findings and emerging data on multiple pathways linking cannabinoids to atherosclerosis, we discuss the literature on the role of cannabinoids in the pathophysiology of atherosclerosis. We also propose a marijuana paradox, which implies that inhalation of marijuana may be linked to precipitation of acute coronary syndromes, but modulation of the endocannabinoid system by a noninhalation route may have a salutary effect on the development of atherosclerosis.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Singla S,Sachdeva R,Mehta JL

doi

10.1002/clc.21962

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

329-35

issue

6

eissn

0160-9289

issn

1932-8737

journal_volume

35

pub_type

杂志文章,评审
  • Carotid intima-media thickness measurement promises to improve cardiovascular risk evaluation in head and neck cancer patients.

    abstract:BACKGROUND:Radiation-treated head and neck cancer (HNC) patients are at high risk for developing radiation vasculopathy, as evidenced by an increased stroke risk. The benefits of screening and assessing the cardiovascular (CV) risk of HNC patients using carotid intima-media thickness (CIMT) ultrasound are not known. Ou...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22389

    authors: Jacoby D,Hajj J,Javaheri A,deGoma E,Lin A,Ahn P,Quon H

    更新日期:2015-05-01 00:00:00

  • Percutaneous Closure of Paravalvular Regurgitation After Transcatheter Aortic Valve Implantation: A Systematic Review.

    abstract::Paravalvular regurgitation (PVR) remains one of the drawbacks of transcatheter aortic valve implantation (TAVI). Details of percutaneous closure (PCC) of PVR after TAVI remain obscure. We aimed to explore the patient characteristics, procedural details, closure devices used, and outcomes of PCC after TAVI. A systemati...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.22569

    authors: Ando T,Takagi H,ALICE (All-Literature Investigation of Cardiovascular Evidence) Group.

    更新日期:2016-10-01 00:00:00

  • Release of adenosine and lactate from human hearts during atrial pacing in patients with ischemic heart disease.

    abstract::Thirty-eight patients treated by atrial pacing were divided into three groups (Group I, patients with neither coronary stenosis nor anginal pain during pacing; Group II, patients with no coronary stenosis but having anginal pain during pacing; Group III, patients with coronary stenosis). The concentrations of adenosin...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960120203

    authors: Haneda T,Ichihara K,Abiko Y,Onodera S

    更新日期:1989-02-01 00:00:00

  • Left ventricular outflow tract obstruction in atrioventricular septal defects: a pathologic and morphometric evaluation.

    abstract::Subaortic stenosis has been described with increasing frequency as an ominous feature of atrioventricular septal defect (AVSD), especially following surgical correction of the anomaly in non-Down's syndrome patients. In order to study the surgical anatomy of the left ventricular outflow tract in this malformation, 48 ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960140611

    authors: Gallo P,Formigari R,Hokayem NJ,D'Offizi F,D'Alessandro,Francalanci P,d'Amati G,Colloridi V,Pizzuto F

    更新日期:1991-06-01 00:00:00

  • Effect of acute exercise on the raised plasma fibrinogen, soluble P-selectin and von Willebrand factor levels in chronic atrial fibrillation.

    abstract:BACKGROUND:There is increasing evidence that chronic atrial fibrillation (AF) is associated with a prothrombotic or hypercoagulable state. HYPOTHESIS:This study was undertaken to determine whether short-term exercise in patients with chronic AF would shift the overall hemostatic balance toward a more prothrombotic sta...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960240512

    authors: Li-Saw-Hee FL,Blann AD,Edmunds E,Gibbs CR,Lip GY

    更新日期:2001-05-01 00:00:00

  • Endovascular stents: preliminary clinical results and future developments.

    abstract::At present, there is an exponential use of new interventional techniques whose proper role and value have not yet been defined. The intracoronary stent is just one example. There is no doubt that stents can be implanted with a high technical success rate associated with highly predictable immediate angiographic result...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960160503

    authors: de Jaegere PP,de Feyter PJ,van der Giessen WJ,Serruys PW

    更新日期:1993-05-01 00:00:00

  • Calcium channel blocker inhibition of AGE and RAGE axis limits renal injury in nondiabetic patients with stage I or II chronic kidney disease.

    abstract:BACKGROUND:There is a growing body of evidence that advanced glycation end products (AGE) and their receptor (RAGE) system are implicated in chronic kidney disease (CKD). We have previously found that a long-acting calcium channel blocker, azelnidipine, but not amlodipine, improves renal injury in CKD patients. However...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/clc.20885

    authors: Nakamura T,Sato E,Fujiwara N,Kawagoe Y,Koide H,Ueda Y,Takeuchi M,Yamagishi S

    更新日期:2011-06-01 00:00:00

  • Evaluation of insulin resistance in normoglycemic patients with coronary artery disease.

    abstract:BACKGROUND:Insulin resistance is clearly associated with coronary artery disease (CAD) in diabetics. Insulin resistance may also be present in normoglycemic individuals, and some of these patients can be diagnosed as having metabolic syndrome (MS) according to various definitions. However, the relationship between hype...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20379

    authors: Deveci E,Yesil M,Akinci B,Yesil S,Postaci N,Arikan E,Koseoglu M

    更新日期:2009-01-01 00:00:00

  • Metastatic cardiac malignant fibrous histiocytoma presenting as right ventricular outflow tract obstruction.

    abstract::An unusual case of metastatic disease of the right ventricle is described in a 74-year-old woman who had presented with a malignant fibrous histiocytoma of the right thigh previously treated with surgery and radiotherapy. Two years later she presented with signs and symptoms of tricuspid regurgitation and right ventri...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960140216

    authors: Kamlow FJ,Padaria SF,Wainwright RJ

    更新日期:1991-02-01 00:00:00

  • Improvement in exercise capacity and associated changes in hemodynamics and left ventricular function after the addition of metoprolol to nifedipine in patients with stable exertional angina.

    abstract::In 10 men with stable exertional angina, the changes in exercise capacity, hemodynamics, and left ventricular (LV) function were measured after 20 mg sublingual nifedipine (N) and again after adding 100 mg oral metoprolol (M). Nifedipine alone did not significantly improve exercise workloads (+18%) and duration (+21%)...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960080405

    authors: Choong CY,Roubin GS,Shen WF,Tokuyasu Y,Harris PJ,Kelly DT

    更新日期:1985-04-01 00:00:00

  • Importance of baseline heart rate as a predictor of cardiac functional recovery in newly diagnosed heart failure with reduced ejection fraction.

    abstract:BACKGROUND:Left ventricular ejection fraction (LVEF) has shown to predict outcomes in patients with heart failure (HF). Left ventricular recovery (LVR) has shown to improve prognosis. HYPOTHESIS:Guideline-directed medical therapy will predict LVR in patients with HF and reduced LVEF. METHODS:We studied 244 patients w...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22937

    authors: Valika A,Paprockas K,Villines D,Costanzo MR

    更新日期:2018-06-01 00:00:00

  • Quantitative frame by frame analysis of regional contraction and lengthening on left ventricular cineangiograms: application to the study of normal left ventricles and left ventricles with mitral valve prolapse.

    abstract::This work attempted to study the segmental wall motion on left ventriculograms, in terms of segmental shortening, velocity of segmental shortening, and temporal sequences of various events in systole as well as in diastole. The ability of such a method to characterize patterns of normal regional wall motion and to det...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960090201

    authors: Colle JP,Le Goff G,Ohayon J,Bonnet J,Bricaud H,Besse P

    更新日期:1986-02-01 00:00:00

  • Contemporary practice pattern of permanent pacing for conduction disorders in inferior ST-elevation myocardial infarction.

    abstract:BACKGROUND:Currently, there is no clear consensus regarding the optimal waiting period before permanent pacemaker implantation in patients with conduction disorders following an inferior myocardial infarction. HYPOTHESIS:We aimed to elucidate the contemporary practice pattern of pacing, especially the timing of pacema...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/clc.23210

    authors: Misumida N,Ogunbayo GO,Catanzaro J,Etaee F,Kim SM,Abdel-Latif A,Ziada KM,Elayi CS

    更新日期:2019-08-01 00:00:00

  • Left atrial inflow propagation rate derived by transesophageal color M-mode echocardiography is a promising index of preload.

    abstract:BACKGROUND:Pulmonary capillary wedge pressure (PCWP) is a useful index of preload and an important determinant of cardiac function. HYPOTHESIS:We postulated that the rate of blood propagating into the left atrium (LAIF-PR) would be a useful measure of PCWP in critically ill patients. METHODS:Fifty-two critically ill ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960260412

    authors: Stoddard MF,Calzada N,Longaker RA

    更新日期:2003-04-01 00:00:00

  • Acute infarction of the left ventricular papillary muscle: electrocardiographic pattern and recognition of its location.

    abstract:BACKGROUND AND HYPOTHESIS:ST-segment depression during acute myocardial infarction (AMI) is known to herald serious hemodynamic complications. Since the mechanism of this dependence is not clear, we reinvestigated the old concept of papillary muscle infarction (PMI) as a cause of marked ST depression. METHODS:Autopsie...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960190514

    authors: Dabrowska B,Walczak E,Prejs R,Zdzienicki M

    更新日期:1996-05-01 00:00:00

  • Effect of cardiopulmonary bypass on cytokine network and myocardial cytokine production.

    abstract:BACKGROUND:In addition to the well-investigated proinflammatory cytokine expression, there is an ever increasing interest in the field of anti-inflammatory response to cardiopulmonary bypass (CPB). Evidence suggests that myocardium serves as an important source of cytokines during reperfusion and application of CPB. Th...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960290708

    authors: Gasz B,Lenard L,Racz B,Benko L,Borsiczky B,Cserepes B,Gal J,Jancso G,Lantos J,Ghosh S,Szabados S,Papp L,Alotti N,Roth E

    更新日期:2006-07-01 00:00:00

  • Dose-ranging study with a new two-chain rt-PA in patients with acute myocardial infarction: a multicenter trial.

    abstract::Tissue-type plasminogen activator (t-PA) derived from a melanoma cell line was first used in patients with acute myocardial infarction in the early 1980s. Recombinant DNA technology then allowed production of large amounts of t-PA. The TIMI-I trial used a two-chain recombinant (rt-PA) product. A predominantly single-c...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/clc.4960160404

    authors: DeWood MA,Kurnik PB,Jolly MK,Jain AC,Khaja F,Gorfinkel HJ,Morris DL,Satler L,LittleJohn J

    更新日期:1993-04-01 00:00:00

  • Electrocardiographic findings in peripartum cardiomyopathy.

    abstract:BACKGROUND:There is limited data on electrocardiographic (ECG) abnormalities and their prognostic significance in women with peripartum cardiomyopathy (PPCM). We sought to characterize ECG findings in PPCM and explore the association of ECG findings with myocardial recovery and clinical outcomes. HYPOTHESIS:We hypothe...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/clc.23171

    authors: Honigberg MC,Elkayam U,Rajagopalan N,Modi K,Briller JE,Drazner MH,Wells GL,McNamara DM,Givertz MM,IPAC Investigators.

    更新日期:2019-05-01 00:00:00

  • Effect of cibenzoline on regional left ventricular function in hypertrophic obstructive cardiomyopathy.

    abstract:BACKGROUND:Cibenzoline, a class Ia antiarrhythmic drug, can be used to relieve left ventricular (LV) outflow obstruction in hypertrophic obstructive cardiomyopathy (HOCM). However, the mechanism of this agent in HOCM has been controversial. HYPOTHESIS:This study was designed to investigate the effect of cibenzoline on...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960230911

    authors: Kondo I,Mizushige K,Nozaki S,Hirao K,Iwado Y,Ohmori K,Matsuo H

    更新日期:2000-09-01 00:00:00

  • Antiarrhythmic drug classifications and the clinician: a gambit in the land of chaos.

    abstract::Several classifications of antiarrhythmic drugs have appeared and all suffer considerable limitations. Recently a Task Force of the Working Group on Arrhythmias of the European Society of Cardiology proposed a novel classification of antiarrhythmic drugs (the so-called Sicilian Gambit) based on their action on the mos...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960170307

    authors: Katritsis D,Camm AJ

    更新日期:1994-03-01 00:00:00

  • Competitive blood flow in the coronary circulation simulating progression of proximal coronary artery disease after saphenous vein bypass surgery.

    abstract::We report a case of competitive blood flow in the left coronary circulation after saphenous vein bypass grafting that resulted in the apparent progression of a proximal stenosis to total occlusion at coronary angiography. Repeat angiography with careful attention to catheter position and adequate injection of contrast...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960070309

    authors: Miller WP,Dash H

    更新日期:1984-03-01 00:00:00

  • Long-term survival of a patient with left ventricular free wall rupture without surgical repair.

    abstract::This report describes the case of a patient who developed postinfarction left ventricular free wall rupture and cardiac tamponade. He was managed conservatively, made a successful recovery, and is alive and asymptomatic 10 months after the index episode. Only 17 cases in which the patients survived subacute rupture of...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960220317

    authors: Mathew TP,Johnston PW,Khan MM,Adgey AA

    更新日期:1999-03-01 00:00:00

  • The importance of pre- and postinfarction angina on timolol-related reduction in mortality and reinfarction.

    abstract::The importance of a history of angina pectoris on long-term timolol treatment after myocardial infarction was studied with respect to mortality and reinfarction. The analyses were performed retrospectively using cohorts from the Norwegian timolol multicenter study. In patients without angina pectoris prior to the infa...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1002/clc.4960080205

    authors: Gundersen T,Kjekshus J

    更新日期:1985-02-01 00:00:00

  • Oxidized low-density lipoprotein and high-density lipoprotein cholesterol modulate coronary arterial remodeling: an intravascular ultrasound study.

    abstract:BACKGROUND:Oxidized low-density lipoprotein (oxLDL) not only plays an important role in plaque formation, but also impairs the endothelium-dependent relaxation. Constrictive remodeling rather than intimal hyperplasia mainly contributes to restenosis after balloon angioplasty. Probucol (powerful antioxidant) reduced res...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960260107

    authors: Yoneyama S,Arakawa K,Yonemura A,Isoda K,Nakamura H,Ohsuzu F

    更新日期:2003-01-01 00:00:00

  • Hyperkalemia-induced bundle branch block and complete heart block.

    abstract::Hyperkalemia was associated with complete heart block in one patient that resolved by first showing right anterior hemiblock). Then the right bundle branch block resolved, leaving the marked left axis deviation that was present before the hyperkalemic episode. Another patient with hyperkalemia had right bundle branch ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960040110

    authors: Ohmae M,Rabkin SW

    更新日期:1981-01-01 00:00:00

  • Transient left ventricular aneurysm in a patient with hypertrophic cardiomyopathy and myocarditis.

    abstract::Left ventricular wall motion abnormalities, aneurysm formation, and progression to global hypokinesis have been described in patients with myocarditis and in patients with hypertrophic cardiomyopathy. We document a case of reversible aneurysm formation, cardiogenic shock, and complete recovery in a patient with myocar...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960160317

    authors: Fisher DZ,DiSalvo TG,Dec GW,DeSanctis RW

    更新日期:1993-03-01 00:00:00

  • Treatment options for angina pectoris and the future role of enhanced external counterpulsation.

    abstract::Patients with coronary artery disease have a variety of treatment options available to them. These include medications to control anginal episodes and, when appropriate, revascularization interventions in the form of coronary artery bypass graft and angioplasty. Despite advances in the treatment of angina, a substanti...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960251407

    authors: Holmes DR Jr

    更新日期:2002-12-01 00:00:00

  • Association of Physical Fitness With the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis.

    abstract::Several studies have investigated the role of physical fitness in atrial fibrillation (AF), but the results remain controversial. We aimed to estimate the association between physical fitness and risk of AF. We comprehensively retrieved data from the Cochrane Library, PubMed, and Embase databases until February 29, 20...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/clc.22552

    authors: Zhu W,Shen Y,Zhou Q,Xu Z,Huang L,Chen Q,Hong K

    更新日期:2016-07-01 00:00:00

  • Improvement of exercise capacity after nifedipine in patients with Eisenmenger syndrome complicating ventricular septal defect.

    abstract::We investigated the potential benefit of a preferential pulmonary vasodilatory effect of nifedipine in 4 patients with Eisenmenger syndrome complicating ventricular septal defect. First-pass radionuclide scan was performed at rest to measure intracardiac shunting before and after nifedipine. Two hours after 20 mg subl...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1002/clc.4960141205

    authors: Wong CK,Yeung DW,Lau CP,Cheng CH,Leung WH

    更新日期:1991-12-01 00:00:00

  • INVEST: results of combined strategies to control blood pressure.

    abstract::The treatment of hypertension continues to be challenging due to the lack of understanding regarding underlying modulators of blood pressure as well as co-existing conditions such as atherosclerosis and diabetes. This has led to uncertainty regarding treatment strategy and intensity. The INternational VErapamil SR/tra...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960241705

    authors: Kolloch RE

    更新日期:2001-11-01 00:00:00