Abstract:
:Tissue-type plasminogen activator (t-PA) derived from a melanoma cell line was first used in patients with acute myocardial infarction in the early 1980s. Recombinant DNA technology then allowed production of large amounts of t-PA. The TIMI-I trial used a two-chain recombinant (rt-PA) product. A predominantly single-chain rt-PA (alteplase) was used in the majority of the TIMI II trial. The present study used a different form of two-chain rt-PA (duteplase) to determine the effective dose for thrombolysis at 60 min, and to evaluate time to reperfusion, reocclusion at 72-96 h, coagulation profiles, and bleeding events. Duteplase was given intravenously to 75 patients a mean of 3.8 +/- 1 h after the onset of myocardial infarction. Following angiography demonstrating coronary occlusion, 23 patients received a low dose of duteplase [0.16-0.29 million international units per kilogram (MIU/kg)] over 60 min followed by a 5-h infusion in conjunction with heparin, 25 patients received a middle dose (0.30-0.41 MIU/kg) and 23 patients received a high dose (0.43-0.74 MIU/kg). Angiography was then performed every 15 min x 4. Progressive recanalization occurred over 60 min (median 45 min) with an overall success rate of 59% (mean 60-min dose: 0.37 MIU/kg). No dose-response relationship was observed. The reocclusion rate was 9% at 72-96 h. Reductions in fibrinogen and plasminogen correlated with dose, but clinical events did not.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
DeWood MA,Kurnik PB,Jolly MK,Jain AC,Khaja F,Gorfinkel HJ,Morris DL,Satler L,LittleJohn Jdoi
10.1002/clc.4960160404subject
Has Abstractpub_date
1993-04-01 00:00:00pages
302-10issue
4eissn
0160-9289issn
1932-8737journal_volume
16pub_type
临床试验,杂志文章,多中心研究abstract:BACKGROUND:Left ventricular ejection fraction (LVEF) has shown to predict outcomes in patients with heart failure (HF). Left ventricular recovery (LVR) has shown to improve prognosis. HYPOTHESIS:Guideline-directed medical therapy will predict LVR in patients with HF and reduced LVEF. METHODS:We studied 244 patients w...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22937
更新日期:2018-06-01 00:00:00
abstract::Cocaine-related cardiovascular events escalated during the 1980s as cocaine became purer, cheaper, and easier to obtain. Cocaine abuse is a risk factor for myocardial ischemia and/or infarction, cardiac arrhythmias, pulmonary edema, ruptured aortic aneurysm, cerebral infarction, infective endocarditis, vascular thromb...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960140626
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Plaque rupture with subsequent transient thrombotic coronary occlusion by a fast-dissolving clot is one of the proposed pathogenic mechanisms in Takotsubo cardiomyopathy (TC). HYPOTHESIS:The aim of this study was to seek evidence for the hypothesis of transient coronary thrombosis as the underlying mechanis...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20747
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Exercise-based rehabilitation is an important part of treatment patients following coronary artery bypass graft (CABG) surgery. HYPOTHESIS:To evaluate effect of very short/short-term exercise training on cardiopulmonary exercise testing (CPET) parameters. METHODS:We studied 54 consecutive patients with myo...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22656
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) is highly beneficial in patients with heart failure (HF) and left bundle branch block (LBBB); however, up to 30% of patients in this selected group are nonresponders. HYPOTHESIS:We hypothesized that clinical and echocardiographic variables can be used to develop a sim...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.23058
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Due to sensorial autonomic neuropathy, the type and severity of angina pectoris in patients with diabetes mellitus (DM) may be rather different from the type and severity of angina pectoris in patients without DM. HYPOTHESIS:The aim of the study was to understand if angina pectoris is related to extensive c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22151
更新日期:2013-08-01 00:00:00
abstract::Far less attention has been paid to the prognostic effect of right-side heart disease on outcomes after transcatheter aortic valve replacement (TAVR) when compared with the left side. Therefore, we performed a systematic review and meta-analysis on the impact of tricuspid regurgitation (TR) and right ventricular (RV) ...
journal_title:Clinical cardiology
pub_type: 杂志文章,meta分析
doi:10.1002/clc.23126
更新日期:2019-01-01 00:00:00
abstract::Infusion of dobutamine in low and high doses in combination with echocardiography can be used for the assessment of myocardial viability and functional significance of coronary artery disease. Improvement of contractile function of hypokinetic or akinetic ventricular wall segment with low-dose dobutamine has a high pr...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960180506
更新日期:1995-05-01 00:00:00
abstract::A patient with severe pulmonary hypertension secondary to the CREST syndrome variant of scleroderma is described. Acute reductions in both pulmonary artery pressure and total pulmonary resistance were seen with nifedipine and oxygen administration. Reductions in resistance were maintained for over one month with this ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960070111
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Conventional approaches to management of congestive heart failure (CHF) rely on drugs that increase myocardial contractility or reduce ventricular afterload. These approaches often improve cardiac symptoms and survival, but may be associated with significant deleterious effects. An alternative approach is to...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960211206
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Data are being accumulated on the presence of inflammatory response in patients with acute coronary syndromes. HYPOTHESIS:The study was undertaken to confirm that the adhesive state of the peripheral blood leukocytes can provide information on an inflammatory process in patients with unstable angina pectori...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960201208
更新日期:1997-12-01 00:00:00
abstract::Antithrombotic and thrombolytic therapies confer clear net benefits in the treatment of acute myocardial infarction (AMI). Antithrombotic therapy with aspirin yields conclusive reductions in vascular mortality as well as reinfarction and stroke and should be administered to all patients with suspected AMI. There is pr...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960201408
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the relationship between left atrial (LA) myocardial function and left ventricular (LV) diastolic dysfunction in subjects with preserved LV ejection fraction (LVEF). METHODS:The study included a group of 118 hypertensive patients and normal subjects. LV diastolic...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20784
更新日期:2010-10-01 00:00:00
abstract::Women's health and well-being are shaped by a combination of healthcare policies that impact the type of health insurance coverage they benefit from, as well as access to preventive, screening, and treatment services. Furthermore, more distal policies, such as those that pertain to housing, education, and employment, ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22896
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Inflammation is a key factor in the development of atherosclerotic disease and acute coronary syndromes (ACS). The P2Y(12) receptor antagonists ticagrelor (AZD6140) and clopidogrel may have anti-inflammatory effects. The objective of this analysis from the Dose Confirmation Study Assessing Anti-Platelet Effe...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.20732
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Cardiac troponin I (cTnI), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hsCRP) each predict adverse cardiac events in chronic heart failure (CHF). However, little is known about the utility of these novel biomarkers of CHF in combination. HYPOTHESIS:: We hyp...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20171
更新日期:2007-08-01 00:00:00
abstract::The cardiokymograph, a relatively new noninvasive device capable of recording anterior left ventricular segmental wall motion, was used to evaluate the frequency and type of wall motion abnormalities in 25 normal patients and in 109 patients with ischemic heart disease. Of the 25 patients with normal coronary arteries...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960030605
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:The Senning operation for transposition of the great arteries (TGA) was first introduced by Senning in 1959 and was revived by Quaegebeur et al. in the late 1970s, thus becoming the intervention of choice for the correction of TGA in many centers. HYPOTHESIS:The purpose of this study was to evaluate the lon...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960271107
更新日期:2004-11-01 00:00:00
abstract::Full recovery occurred after 15 months of severe congestive heart failure in a patient with peripartum cardiomyopathy. Clinical improvement was noted when propranolol was added to conventional therapy. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960030211
更新日期:1980-08-01 00:00:00
abstract::Severe aortic regurgitation may be associated with premature aortic valve opening. Several possible etiologies for this diastolic opening have been suggested. We present a patient with hemodynamic data, M-mode and 2-D echocardiography in the setting of severe aortic regurgitation and diastolic aortic valve opening. Ou...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090513
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Radiation-treated head and neck cancer (HNC) patients are at high risk for developing radiation vasculopathy, as evidenced by an increased stroke risk. The benefits of screening and assessing the cardiovascular (CV) risk of HNC patients using carotid intima-media thickness (CIMT) ultrasound are not known. Ou...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22389
更新日期:2015-05-01 00:00:00
abstract::A 62-year-old man was admitted to our hospital with unstable angina. The coronary arteriography showed the occlusion of the left anterior descending artery and other stenotic lesions. The patient underwent an aortocoronary bypass operation, but unfortunately he did not survive. Surprisingly, the necropsy revealed him ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960091113
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:One-third of patients who receive cardiac resynchronization therapy (CRT) are classified as nonresponders. Characteristics of responders to CRT have been studied in multiple clinical trials. HYPOTHESIS:Independent predictors of CRT response may be identified by studying a series of patients in routine clini...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22043
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The objective of this study was to estimate the prevalence of prehypertension and hypertension in the rural adults of Liaoning province of China. METHODS:The study was conducted in 2004-2006, using a multistage cluster sampling method to select a representative sample. A total of 45925 adults, 35 years or o...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20073
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Insulin resistance is clearly associated with coronary artery disease (CAD) in diabetics. Insulin resistance may also be present in normoglycemic individuals, and some of these patients can be diagnosed as having metabolic syndrome (MS) according to various definitions. However, the relationship between hype...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20379
更新日期:2009-01-01 00:00:00
abstract::A 49-year-old female with significant (75%) left main coronary artery stenosis was initially considered to have developed early obstruction of a saphenous vein graft to the left anterior descending coronary artery, because of recurrent postoperative angina. In a second catheterization study, left ventriculography show...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100413
更新日期:1987-04-01 00:00:00
abstract::Rapid assessment of patients presenting with acute chest pain is essential, in order to distinguish between those who have a life-threatening condition, such as myocardial infarction or unstable angina, and the substantial proportion who do not have an acute coronary syndrome. It is thus of vital importance that relia...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960231306
更新日期:2000-01-01 00:00:00
abstract::Lipoprotein (a) [Lp(a)] concentrations were determined in 365 patients undergoing coronary angiography for stable angina (n = 159), unstable angina (n = 99), recent myocardial infarction (n = 45), and nonischemic heart disease (cardiomyopathy or valvular disease, n = 62, non-IHD). Mean +/- SD and median Lp(a) concentr...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960180909
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:The efficacy of prophylactic coronary revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery in patients with abdominal aortic aneurysm (AAA) scheduled for open repair surgery remains controversial. HYPOTHESIS:Concomitant coronary artery disease (CAD) ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20335
更新日期:2008-12-01 00:00:00
abstract::A total of 1150 consecutive patients (1052 males and 98 females; age 51.2 +/- 10.1 years) with suspected coronary artery disease (Group I) were subjected to fluoroscopy for detection of coronary artery calcification (CAC) and coronary angiography. Another group (Group II) of 120 patients (95 males and 25 females; age ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960110705
更新日期:1988-07-01 00:00:00