Abstract:
:Lipoprotein (a) [Lp(a)] concentrations were determined in 365 patients undergoing coronary angiography for stable angina (n = 159), unstable angina (n = 99), recent myocardial infarction (n = 45), and nonischemic heart disease (cardiomyopathy or valvular disease, n = 62, non-IHD). Mean +/- SD and median Lp(a) concentrations in stable angina (29.9 +/- 29.2;22 mg/dl) did not differ from those in non-IHD (26.9 +/- 26.3; 17), but were significantly lower than in patients with unstable angina (52.7 +/- 36.6; 58) and myocardial infarction (44.8 +/- 36.4; 34) (p < 0.01). Coronary angiography revealed that 261 patients, including 4 patients in the non-IHD group, had significant (> or = 50%) coronary lesions. Lp(a) was higher in patients with (41 +/- 35; 32) than in those without (28 +/- 27; 19) angiographic evidence of significant coronary stenosis (p < 0.05) and showed a weak univariate correlation with the angiographic index (Total Score) of the severity of the disease (r = 0.106;p < 0.05). However, in the subgroup of 303 patients with stable/unstable angina or myocardial infarction, Lp(a) was predictive neither of angiographic presence nor of severity of coronary disease. Patients were then ranked according to the Total Score values. Among patients with comparable angiographic severity of coronary artery disease, Lp(a) appeared to be remarkably higher in patients with acute ischemic syndromes (unstable angina, myocardial infarction) than in patients with stable angina. In conclusion, Lp(a) was roughly twice as high in acute (unstable angina, myocardial infarction) than in chronic (stable angina) ischemic syndromes, but there was no difference between chronic stable angina and non-IHD.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Brunelli C,Spallarossa P,Bertolini S,Balbi M,Barbara C,Masturzo P,Lantieri PB,Pastorini C,Caponnetto Sdoi
10.1002/clc.4960180909subject
Has Abstractpub_date
1995-09-01 00:00:00pages
526-9issue
9eissn
0160-9289issn
1932-8737journal_volume
18pub_type
杂志文章abstract::Thirty-eight patients treated by atrial pacing were divided into three groups (Group I, patients with neither coronary stenosis nor anginal pain during pacing; Group II, patients with no coronary stenosis but having anginal pain during pacing; Group III, patients with coronary stenosis). The concentrations of adenosin...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120203
更新日期:1989-02-01 00:00:00
abstract::A case of aortic ball valve prosthesis malfunction is described in which the poppet became alternately stuck in the open and closed position. The patient experienced chest pain followed by pulmonary edema and cardiac arrest. Malfunction of prosthetic valve was diagnosed on echocardiogram and cardiopulmonary resuscitat...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960051105
更新日期:1982-11-01 00:00:00
abstract::Many invasive and noninvasive methods have been used to study the cardiac atria; however, few allow quantitative measurement of atrial function. To determine the interaction between left ventricular (LV) contraction and left atrial (LA) filling, gated radionuclide angiography was conducted in 30 normal subjects (24 me...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170508
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Randomized controlled trials showed the nonvitamin K oral anticoagulant (NOAC) edoxaban was effective and safe for stroke and systemic embolism prevention in nonvalvular atrial fibrillation (AF) and for the prevention and treatment of venous thromboembolism (VTE; including pulmonary embolism and deep vein th...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23279
更新日期:2019-12-01 00:00:00
abstract::A total of 231 patients suffering from a first acute myocardial infarction were randomly allocated within 4 hours following the onset of symptoms either to anistreplase or anisoylated plasminogen streptokinase activator complex (APSAC), 30 U over 5 minutes, or to conventional heparin therapy, 5000 IU in bolus injectio...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1002/clc.4960131310
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:The present European guidelines suggest a diagnostic electrophysiological (EP) study to determine indication for cardiac pacing in patients with bundle branch block and unexplained syncope. We evaluated the prognostic relevance of an EP study for mortality and the development of permanent complete atrioventr...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22700
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the relationship between left atrial (LA) myocardial function and left ventricular (LV) diastolic dysfunction in subjects with preserved LV ejection fraction (LVEF). METHODS:The study included a group of 118 hypertensive patients and normal subjects. LV diastolic...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20784
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is a complex cardiac arrhythmia in clinical practice with increasing incidence. However, the effects of statins on patients with AF are not quite clear. HYPOTHESIS:To investigate the protective effect of calcium channel blocker (CCB) and valsartan combined fluvastatin on hypertensio...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23487
更新日期:2020-12-01 00:00:00
abstract::Embolism of a fragment of a central venous catheter is a serious clinical complication, especially when the fragment cannot be made visible by radiological methods. We report a case where such a fragment could only be localized by transesophageal echocardiography (TEE). With combined use of x-rays and TEE, the cathete...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110614
更新日期:1988-06-01 00:00:00
abstract::The effects of monotherapy with atenolol or diltiazem-SR on blood pressure, 24-h blood pressure (BP) load, and exercise capacity were tested in patients with mild to moderate (stages I and II) essential hypertension. After 3-week single-blind placebo therapy, patients with sitting diastolic blood pressure (SDBP) of 94...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960171209
更新日期:1994-12-01 00:00:00
abstract::Malignant lymphoma commonly involves the heart. Previous studies have found cardiac metastases in up to 20% of patients dying with lymphoma. Cardiac signs and symptoms of lymphoma are relatively rare, however, and in most cases, the diagnosis is made either postmortem or too late to affect the clinical course. This re...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190326
更新日期:1996-03-01 00:00:00
abstract::Many patients with coronary artery disease treated by percutaneous transluminal coronary angioplasty (PTCA) have a history of previous myocardial injury resulting in a reduced left ventricular ejection fraction (EF). The effects of successful PTCA on myocardial perfusion and left ventricular function in these patients...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120504
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Isolated left ventricular abnormal trabeculation (ILVAT) is defined as > 3 coarse trabeculations of the left ventricular wall, apically to the papillary muscles, in hearts without congenital malformations. HYPOTHESIS:The aims of the study were to assess by echocardiography the prevalence of ILVAT, to confir...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220212
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that viable but stunned myocardium displays contractile reserve and exhibits cardiac cycle-dependent variations of integrated backscatter (CVIB), whereas infarcted myocardium does not. HYPOTHESIS:This study was designed to clarify whether assessment of the acoustic properties of ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960261010
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Although ischemic threshold reportedly is lower in the early morning than in the afternoon, the mechanisms that account for the diurnal change in minimal coronary vascular resistance in the potentially ischemic area are unknown. HYPOTHESIS:We hypothesized that calcium-channel blockers and alpha 1 blockers m...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960210512
更新日期:1998-05-01 00:00:00
abstract::During myocardial ischemia, fatty acids are the principal source of energy, increasing myocardial oxygen consumption and making a decrease in coronary blood flow less well tolerated. Increasing glucose oxidation during myocardial ischemia may improve cardiac efficiency. The pFOX inhibitors have the potential to accomp...
journal_title:Clinical cardiology
pub_type: 社论
doi:10.1002/clc.4960260402
更新日期:2003-04-01 00:00:00
abstract::The prevalence of interatrial block (IAB) is high in the elderly, particularly in those with heart disease. Despite this high prevalence-and the association of IAB with the risk of atrial fibrillation (AF), stroke, and cognitive decline-little information exists about the prognosis of older patients with IAB. P-wave d...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/clc.22647
更新日期:2017-04-01 00:00:00
abstract::In 2009, much was written about computed tomography (CT) angiography of the coronary circulation and little about catheter-based coronary angiography, despite its continued use since 1958 in patients with all types of cardiac disease or potential disease. ...
journal_title:Clinical cardiology
pub_type: 评论,社论
doi:10.1002/clc.20741
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The role of atrial rate-responsive (RR) pacing in cardiac resynchronization therapy (CRT) is unclear due to the favorable effect of rate lowering in systolic heart failure. Atrial high rate episodes (AHREs) in CRT recipients are particularly worrisome since they cause loss of CRT, beyond representing a strok...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23227
更新日期:2019-07-07 00:00:00
abstract::Triglyceride (TG) has long been associated as a risk factor for coronary artery disease. A recent meta-analysis of various epidemiologic studies has confirmed this link. An important issue is to assess further the appropriate cutpoints to classify desirable TG because recent data indicate that levels < 200 mg/dl confe...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960221402
更新日期:1999-06-01 00:00:00
abstract::In patients with malignant ventricular arrhythmias, antiarrhythmic therapy is known to carry a substantial risk of proarrhythmia. This risk is usually considered to be low when supraventricular arrhythmias or benign ventricular arrhythmias are considered. We were able to collect data on four patients without a history...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170410
更新日期:1994-04-01 00:00:00
abstract::The impact of transient myocardial ischemia on left ventricular function was examined by digital subtraction left ventricular angiography. Contrast medium was injected into the right pulmonary artery before, at 60 seconds of balloon inflation, and 10 minutes after balloon deflation. A total of 69 patients completed th...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960140808
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Current National Cholesterol Education Program (NCEP) guidelines recognize low-density lipoprotein cholesterol (LDL-C) below 100 mg/dl as an optimal level. Evidence supporting this is scant. Both LDL-C and C reactive protein (CRP) are known correlates of atherosclerosis progression. HYPOTHESIS:We examined t...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960270105
更新日期:2004-01-01 00:00:00
abstract::We report a patient who presented with new onset atrial fibrillation in the setting of inferior ST-segment elevation myocardial infarction (STEMI). Cardiac catheterization revealed proximal occlusion of the left circumflex artery. Balloon angioplasty and stenting restored flow to a large left atrial branch, with promp...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20573
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:The introduction of drug-eluting stents (DES) dramatically changed the practice of percutaneous coronary intervention (PCI) in the 2000s. Little is known about trends in in-hospital outcome after PCI in the DES era. HYPOTHESIS:The in-hospital outcomes after PCI might be continuously improved over time. MET...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20786
更新日期:2010-08-01 00:00:00
abstract::A case of systemic hypotension with volume depletion not responding to intravenous fluids was found to have features of cardiac tamponade on two-dimensional (2-D) echocardiography. Intracardiac pressures were normal on cardiac catheterization. An interesting observation was the presence of left ventricular (LV) collap...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960210318
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Exercise-induced dyspnea is a frequent feature in patients with hyperthyroidism. HYPOTHESIS:Data from clinical studies to elucidate the origin of this symptom are lacking. In the current study, we examined the hemodynamic and oxygenation responses to exercise and beta-adrenergic blockade in patients with hy...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270707
更新日期:2004-07-01 00:00:00
abstract::Atrial septal aneurysm in the otherwise normal heart is a very rare and usually asymptomatic condition. A midsystolic click was described as the only clinical manifestation so far. A low-pitched early-to-midsystolic acoustic phenomenon in a 39-year-old woman corresponding with maximal leftward motion of the aneurysmat...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960150713
更新日期:1992-07-01 00:00:00
abstract::The question of whether several attempts at transducer insertion increase the risk of performing transesophageal echocardiography (TEE) in patients with coronary artery disease (CAD) has not been addressed to date. In the course of performing TEE in 45 patients with CAD, two or more attempts to insert the transducer w...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960160807
更新日期:1993-08-01 00:00:00
abstract::In a series of 20 coronary excimer laser angioplasties, two patients presented with a peculiar type of malignant restenosis 6 and 8 weeks after a successful laser angioplasty procedure. One patient had a successful recanalization of an occluded left anterior descending (LAD) coronary artery and the second patient had ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960130606
更新日期:1990-06-01 00:00:00