Abstract:
BACKGROUND:Plaque rupture with subsequent transient thrombotic coronary occlusion by a fast-dissolving clot is one of the proposed pathogenic mechanisms in Takotsubo cardiomyopathy (TC). HYPOTHESIS:The aim of this study was to seek evidence for the hypothesis of transient coronary thrombosis as the underlying mechanism of TC by means of intravascular ultrasound (IVUS). METHODS:In our database of 63 consecutive patients with TC we identified 10 patients (16%) who had undergone IVUS during their initial left heart catheterisation. RESULTS:A median length of 67 mm of the left anterior descending artery was analyzed (interquartile range [IQR]: 63.3-70.1 mm). Median lumen diameter, median vessel diameter, median plaque and media volume were 2.9 mm (IQR: 2.7-3.1 mm), 4.2 mm (IQR: 3.8-4.4 mm), and 90.9 mm(3) (IQR: 70.4-101.4 mm(3)), respectively. Plaque rupture, positive remodeling, and presumed intracoronary thrombus were absent in all patients. CONCLUSION:In conclusion, plaque rupture does not account for the regional wall motion abnormalities observed in TC. The previously reported observation of plaque rupture in TC seems to constitute an incidental finding. We suggest that the theory of aborted myocardial infarction as the underlying cause of TC should be abandoned once and for all.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Haghi D,Roehm S,Hamm K,Harder N,Suselbeck T,Borggrefe M,Papavassiliu Tdoi
10.1002/clc.20747subject
Has Abstractpub_date
2010-05-01 00:00:00pages
307-10issue
5eissn
0160-9289issn
1932-8737journal_volume
33pub_type
杂志文章abstract:BACKGROUND:Most information concerning hypertrophic cardiomyopathy has been derived from western countries and Japan. HYPOTHESIS:Patients with hypertrophic cardiomyopathy in Taiwan may have a distinct morphology and clinical picture. METHODS:Information from 163 consecutive patients with hypertrophic cardiomyopathy a...
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