Antiarrhythmic drug classifications and the clinician: a gambit in the land of chaos.

Abstract:

:Several classifications of antiarrhythmic drugs have appeared and all suffer considerable limitations. Recently a Task Force of the Working Group on Arrhythmias of the European Society of Cardiology proposed a novel classification of antiarrhythmic drugs (the so-called Sicilian Gambit) based on their action on the most vulnerable parameter of an arrhythmogenic mechanism. The present article attempts a critical reappraisal of the antiarrhythmic drug actions and the relationship of vulnerable parameters with cellular mechanisms such as ion channels. The clinical applicability of these concepts, the implications of the new classification in the pharmacologic therapy of arrhythmias, and its potential limitations are discussed.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Katritsis D,Camm AJ

doi

10.1002/clc.4960170307

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

142-8

issue

3

eissn

0160-9289

issn

1932-8737

journal_volume

17

pub_type

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