Abstract:
:Several classifications of antiarrhythmic drugs have appeared and all suffer considerable limitations. Recently a Task Force of the Working Group on Arrhythmias of the European Society of Cardiology proposed a novel classification of antiarrhythmic drugs (the so-called Sicilian Gambit) based on their action on the most vulnerable parameter of an arrhythmogenic mechanism. The present article attempts a critical reappraisal of the antiarrhythmic drug actions and the relationship of vulnerable parameters with cellular mechanisms such as ion channels. The clinical applicability of these concepts, the implications of the new classification in the pharmacologic therapy of arrhythmias, and its potential limitations are discussed.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Katritsis D,Camm AJdoi
10.1002/clc.4960170307subject
Has Abstractpub_date
1994-03-01 00:00:00pages
142-8issue
3eissn
0160-9289issn
1932-8737journal_volume
17pub_type
杂志文章,评审abstract::High dose-dobutamine (DOB) has been previously used as a pharmacological stress test to evaluate wall motion abnormalities. As a result, recent stress echocardiography with low-dose DOB has been reported to be valuable for investigating stunned myocardium after thrombolysis. However, echocardiography requires an opera...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960160604
更新日期:1993-06-01 00:00:00
abstract::In addition to the role of the electrophysiological substrate, paroxysmal atrial fibrillation depends on the modulation of the atrial tissues by the autonomic nervous system. Experimentally, models of atrial fibrillation can be based on either adrenergic or vagal stimulations that provoke the arrhythmia by disturbing ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960130311
更新日期:1990-03-01 00:00:00
abstract::In the last 15 years, intense interest has focused on various interventional, pharmacologic, and mechanical forms of therapy for the treatment of atherosclerotic coronary artery disease. Many techniques and devices (dilating balloons, perfusion catheters, thermal probes and balloons, lasers, atherectomy devices, stent...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960150812
更新日期:1992-08-01 00:00:00
abstract::A patient with severe pulmonary hypertension secondary to the CREST syndrome variant of scleroderma is described. Acute reductions in both pulmonary artery pressure and total pulmonary resistance were seen with nifedipine and oxygen administration. Reductions in resistance were maintained for over one month with this ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960070111
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Overt hypothyroidism has been found to be associated with cardiovascular disease. Moreover, subclinical hypothyroidism is a strong indicator of risk for aortic atherosclerosis and myocardial infarction. HYPOTHESIS:We hypothesized that variation of thyroid function within the normal range may influence the p...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960261205
更新日期:2003-12-01 00:00:00
abstract::In-coordinate mitral annulus movement might participate in the pathogenesis of functional mitral regurgitation. We evaluated a relationship between indices of mitral annulus systolic asynchrony and mitral regurgitation in patients after myocardial infarction in order to determine independent determinants of effective ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20131
更新日期:2007-10-01 00:00:00
abstract::The coronary artery thrombus that causes acute myocardial infarction can be lysed, and reperfusion can be achieved, in the first few hours after infarction. However, the infarct vessel will reocclude in 15-30% of patients, and this event is frequently associated with pain, reinfarction, arrhythmias, or death. The risk...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960080902
更新日期:1985-09-01 00:00:00
abstract::Paravalvular regurgitation (PVR) remains one of the drawbacks of transcatheter aortic valve implantation (TAVI). Details of percutaneous closure (PCC) of PVR after TAVI remain obscure. We aimed to explore the patient characteristics, procedural details, closure devices used, and outcomes of PCC after TAVI. A systemati...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22569
更新日期:2016-10-01 00:00:00
abstract::Hyperkalemia was associated with complete heart block in one patient that resolved by first showing right anterior hemiblock). Then the right bundle branch block resolved, leaving the marked left axis deviation that was present before the hyperkalemic episode. Another patient with hyperkalemia had right bundle branch ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960040110
更新日期:1981-01-01 00:00:00
abstract::ACC/AHA guidelines assign a class I indication for use of myocardial perfusion imaging (MPI) for the evaluation of chest pain in patients with acute coronary syndromes and a nondiagnostic ECG. However, MPI is not a widely used modality for the evaluation of patients who present to the ER with chest pain and an interme...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20549
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The present European guidelines suggest a diagnostic electrophysiological (EP) study to determine indication for cardiac pacing in patients with bundle branch block and unexplained syncope. We evaluated the prognostic relevance of an EP study for mortality and the development of permanent complete atrioventr...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22700
更新日期:2017-08-01 00:00:00
abstract::Antihypertensive drug therapy can lower blood pressure and prolong life, but many hypertensive patients continue to develop further risk factors and to die prematurely of heart disease. Antihypertensive drugs can also interfere with the patient's quality of life, and many are not compatible with the concomitant medica...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960181506
更新日期:1995-06-01 00:00:00
abstract::This report reviews the available evidence for and against the combined use of clonidine and prazosin in treating hypertension. Clinical studies have resulted in modest or no enhancement of the antihypertensive effects when prazosin has been added to clonidine. This report discusses the possible mechanisms of an inter...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960081206
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:ST-segment depression during acute myocardial infarction (AMI) is known to herald serious hemodynamic complications. Since the mechanism of this dependence is not clear, we reinvestigated the old concept of papillary muscle infarction (PMI) as a cause of marked ST depression. METHODS:Autopsie...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190514
更新日期:1996-05-01 00:00:00
abstract::This manuscript was written in an effort to emphasize the points made by Porter et al. (Clin Cardiol 1997; 20:971-973). Right ventricular infarction may be erroneously interpreted as an anteroseptal infarction because of elevation of the S-T segments in leads V1-V4. The two can be separated when, using the Grant metho...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960210411
更新日期:1998-04-01 00:00:00
abstract::Sixteen patients with metastatic carcinoid tumors of ileal or cecal origin were studied in order to evaluate the frequency and degree of cardiac involvement in a nonselected patient group. We have also studied the correlation between plasma hormone levels (e.g., 5-hydroxytryptamine (5-HT) and substance P) and the degr...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090104
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Females with Ullrich-Turner syndrome (UTS) have typical clinical features such as short stature, ovarian failure, visible dysmorphic stigmata, and abnormalities in different organs such as kidney or heart. HYPOTHESIS:The aim of the present study was to analyze the distribution, prevalence, and relative risk...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960280209
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:In clinical cardiology, heart rate variability is a putative index of autonomic cardiovascular function. Signs of reduced vagal activity are not only associated with an enhanced risk of sudden cardiac death, but such impaired heart rate variability became a new predictor of sudden cardiac death and other mor...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960200710
更新日期:1997-07-01 00:00:00
abstract::Coronary artery stents have been developed to overcome arterial abrupt closure and restenosis following balloon angioplasty. Complications of stent insertion include loss of the device from its delivery system into the peripheral circulation. Certain types of stents are almost radiolucent, making localization of the l...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960180313
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Epidemiologic evidence suggests that an elevated heart rate (HR) is an adverse and independent prognostic factor in arterial hypertension and other cardiovascular diseases. Although diltiazem is characterized as an HR-lowering calcium antagonist, no studies have quantified the magnitude of HR changes in pati...
journal_title:Clinical cardiology
pub_type: 杂志文章,meta分析
doi:10.1002/clc.4960240112
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Due to chronic inflammatory status, rheumatoid arthritis (RA) patients are exposed to changes in left ventricular (LV) geometry and function. We assessed prevalence, factors associated with, and prognostic role of concentric LV geometry and systolic dysfunction (LVSD) detected by echocardiography in a large ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22926
更新日期:2018-06-01 00:00:00
abstract::The long-term effects of valve replacement for chronic isolated aortic regurgitation as assessed by first-pass exercise radionuclide angiography have never been reported. We studied 20 males and 5 females before, 15 months postoperatively, and from 29 to 109 (mean 62 +/- 21) months following valve replacement with exe...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110403
更新日期:1988-04-01 00:00:00
abstract::There is an apparent benefit with extension of dual antiplatelet therapy (DAPT) beyond 1 year after implantation of drug-eluting stents (DES). Assessment by a Double Randomization of a Conventional Antiplatelet Strategy vs a Monitoring-Guided Strategy for Drug-Eluting Stent Implantation, and of Treatment Interruption ...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.22512
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The two most useful methods for myocardial viability assessment are perfusion imaging and dobutamine echocardiography. HYPOTHESIS:The present study investigated the additive value of a new method, dobutamine technetium 99m (99mTc)-sestamibi-gated single-photon emission computed tomography (SPECT), which com...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960261111
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Cardiac injury is common in COVID-19 patients and is associated with increased mortality. However, it remains unclear if reduced cardiac function is associated with cardiac injury, and additionally if mortality risk is increased among those with reduced cardiac function in COVID-19 patients. HYPOTHESIS:The ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23479
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is the third cause of acute deterioration of renal function in hospitalized patients. HYPOTHESIS:The purpose of the study was to compare the efficacy of saline infusion, saline infusion plus N-acetylcysteine (NAC), and sodium bicarbonate (SB) infusion to prevent CIN in pat...
journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.20576
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Guidelines suggest that "upstream" P2Y12 receptor antagonists should be considered in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). HYPOTHESIS:Early use of ticagrelor in patients managed with an invasive strategy would be more effective than clopidogrel because of its more rapi...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.22733
更新日期:2017-06-01 00:00:00
abstract::In a family affected by arrhythmogenic right ventricular cardiomyopathy (ARVC) the familial occurrence was investigated. All 14 members of two generations were investigated carefully, and only 2 (father and one son) members were affected. Both subjects had a massive form of the disease with relevant ventricular arrhyt...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960150314
更新日期:1992-03-01 00:00:00
abstract::A method for noninvasive generation of central aortic systolic pressure curves is presented. The method is based on plotting the occlusive pressure values applied at the brachial artery level against the time intervals needed for the aortic pressure wave to equalize and break through the occlusive pressure at the brac...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100402
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:The maximal negative dP/dt [max (-)dP/dt] and time constant (T) are useful indices for evaluating left ventricular (LV) relaxation, but they require invasive procedures. HYPOTHESIS:The purpose of this study was to obtain max (-)dP/dt and T using the continuous-wave Doppler aortic regurgitation velocity curv...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190907
更新日期:1996-09-01 00:00:00