Abstract:
BACKGROUND:The maximal negative dP/dt [max (-)dP/dt] and time constant (T) are useful indices for evaluating left ventricular (LV) relaxation, but they require invasive procedures. HYPOTHESIS:The purpose of this study was to obtain max (-)dP/dt and T using the continuous-wave Doppler aortic regurgitation velocity curve (AR-CW) noninvasively. Using the Bernoulli equation, the AR-CW allows accurate determination of the pressure gradients (PG) between the aorta and the left ventricle. METHODS:In 10 patients with trivial to mild AR, the rising segment of the AR-CW reflecting LV pressure decrease was digitized with the cardiac image analysis system. Transpulmonary contrast-enhanced Doppler echocardiography was used in three patients to obtain intense velocity envelope. The PG curve and the firs derivative curve were reconstructed and the maximal point of the first derivative curve, which is consistent with max(-)dP/dt, was termed as maximal rate of pressure fall (maxRPF). As T (calculated according to the method of Weiss) can be obtained from T=Pm/max(-)dP/dt [Pm: LV pressure at the phase of max(-)dP/dt], we calculated T from Pm/maxRPF (Pm=dicrotic notch pressure-4Vm2) (Vm: AR velocity at the phase of maxRPF). RESULTS:The Doppler-derived maxRPF and T (TD) approximated the catheter-derived max(-)dP/dt and T (y = 0.85x + 245, r = 0.97, p < 0.001, y = 0.79x + 4, r = 0.87, p < 0.001). In addition, dobutamine echocardiography was performed in nine patients showing increased maxRPF and decreased TD, indicating improvement of LV relaxation. CONCLUSION:These Doppler-derived new indices are sufficiently useful to evaluate LV relaxation noninvasively.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Honda Y,Yokota Y,Yokoyama Mdoi
10.1002/clc.4960190907subject
Has Abstractpub_date
1996-09-01 00:00:00pages
709-15issue
9eissn
0160-9289issn
1932-8737journal_volume
19pub_type
杂志文章abstract::The usual normal S-T segment of the surface electrocardiogram (ECG) contributes little to the diagnostic procedure. When the S-T segment is too long or too short, or when it is displaced upward or downward, it is commonly abnormal. Under such circumstances, an S-T segment abnormality usually contributes considerable d...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960200602
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Increased salt intake may induce hypertension, lead to cardiac hypertrophy, and exacerbate heart failure. When elderly patients develop heart failure, diastolic dysfunction is often observed, although the ejection fraction has decreased. Diabetes mellitus (DM) is an established risk factor for heart failure....
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20664
更新日期:2009-10-01 00:00:00
abstract::The use of contrast echocardiography (CE) in cardiovascular medicine has grown significantly over the last 15 years. Depending on the site of injection, contrast enhancement of the right- or left-sided cardiac chambers or myocardium now can be achieved. Contrast echocardiography can improve the evaluation of patients ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960201308
更新日期:1997-10-01 00:00:00
abstract::When evaluating patients with possible coronary artery disease, it is necessary to combine physiologic assessment (measurements of ischemia) with anatomic pathologic assessment (coronary angiography). Coronary angiography currently is the only way to assess the anatomic pathology of the coronary circulation with preci...
journal_title:Clinical cardiology
pub_type: 社论
doi:10.1002/clc.4960270202
更新日期:2004-02-01 00:00:00
abstract::The role of catecholamine in atrial natriuretic peptide (ANP) secretion and its secretory mechanism in normal humans is not well defined; therefore, we studied the relationship among ANP, catecholamine, and atrial pressures in 25 patients without cardiovascular disease and in 35 patients with chronic congestive heart ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110402
更新日期:1988-04-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960241107
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Prior studies suggest that the incidence of ventricular arrhythmias is high in patients with Fabry cardiomyopathy. This study evaluated the incidence of significant arrhythmias in a series of patients with Fabry cardiomyopathy. HYPOTHESIS:Arrhythmias are important causes of morbidity and mortality in Fabry ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22047
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The finding of aortic regurgitation at a classical examination is a diastolic murmur. HYPOTHESIS:Aortic regurgitation is more likely to be associated with a systolic than with a diastolic murmur during routine screening by a noncardiologist physician. METHODS:In all, 243 asymptomatic patients (mean age 42 ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270905
更新日期:2004-09-01 00:00:00
abstract::Acute myocardial infarction can be stratified into electrocardiographic subsets based on the presence or absence of new Q waves. This stratification has important clinical and prognostic utility. Coronary angiography during acute non-Q-wave compared with Q-wave infarction shows much higher infarct-related artery paten...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1989-07-01 00:00:00
abstract::A community-wide study of patients hospitalized with acute myocardial infarction in metropolitan Baltimore was conducted to examine socio-demographic and clinical characteristics in association with ventricular fibrillation and cardiac arrest (VF/CA). Multivariate analyses revealed that variables significantly associa...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960040404
更新日期:1981-07-01 00:00:00
abstract:BACKGROUND:ECG U-wave inversion can be classified as initial and terminal U inversion according to the phasic relationship to positive U-wave deflection. Initial U inversion is occasionally observed in hypertensive patients while terminal U inversion frequently appears during severe myocardial ischemia. HYPOTHESIS:The...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20487
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Troponin I (TnI) is increasingly employed as a highly specific marker of acute myocardial ischemia. The value of this marker after cardiac surgery is unclear. HYPOTHESIS:The purpose of this study was to measure serum TnI levels prospectively at 1, 6, and 72 h after elective cardiac operations. In addition, ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960231009
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) readmission rates have become an increasingly important quality metric since the advent of the Hospital Readmissions Reduction Program. Despite many well-intentioned efforts to reduce readmissions, clinicians continue to struggle with the problem of high HF readmission rates. HYPOTHESIS:H...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22738
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:The normal and dilated heart behaves as a single functional unit during preload reduction: volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling. HYPOTHESIS:We hypothesized that reduction of venous return induced by a physiologic stimulus (ti...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960260909
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:The global T-inversion (GTI) electrocardiogram (ECG) is strikingly abnormal with major QTc prolongation, but with a surprisingly good prognosis by Kaplan-Meier curve. This contrasts with most significant QTc prolongations. HYPOTHESIS:This study was undertaken to ascertain QT interval dispersion (QTd) in glo...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960221012
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:C-reactive protein (CRP) and myeloperoxidase (MPO) are involved in the pathogenesis of atherosclerosis, mainly during periods of instabilization. This study aims to test the hypothesis that patients with acute coronary syndrome (ACS) maintain a persistent inflammatory state, and that this is associated with ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20462
更新日期:2009-11-01 00:00:00
abstract::Cardiac rehabilitation (CR) is an important component in the continuum of care for patients with cardiovascular diseases, including the older population. Benefits of CR which include mortality benefit, decreased hospitalizations, increased functional capacity all extend to an older population. In Medicare beneficiarie...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.23296
更新日期:2020-02-01 00:00:00
abstract:BACKGROUNDS:The causes and prognosis of pericardial effusion (PE) may be different according to time, region, economy, and hospital. This study was performed to evaluate the etiology, clinical outcome, and prognosis of patients with large, symptomatic PE treated by echo-guided pericardiocentesis at Kangnam St. Mary's H...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20305
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:It is known that exercise-induced ST-segment elevation in lead V1 (V1-E) detects left anterior descending (LAD) stenosis. It was also postulated that ST elevation in aVR and simultaneous ST depression in V5 (aVR-E + V5-D) is a marker of ischemia due to significant stenosis of the LAD in patients with single-...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960260506
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Advanced practice providers (APPs) can fill care gaps created by physician shortages and improve adherence/compliance with preventive ASCVD interventions. HYPOTHESIS:APPs utilizing guideline-based algorithms will more frequently escalate ASCVD risk factor therapies. METHODS:We retrospectively reviewed data...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22963
更新日期:2018-06-01 00:00:00
abstract::The purpose of this study was to examine signal-averaged electrocardiographic (SA-ECG) late potentials to predict ventricular arrhythmias during intrinsic cardiac rhythm and during ventricular pacing in children with complete heart block (CHB). Recordings of SA-ECG were obtained from eight patients (aged 3-18 years) w...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170610
更新日期:1994-06-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960170207
更新日期:1994-02-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960030211
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:To evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or nonsustained ventricular tachycardia (NSVT) after acute coronary syndrome (ACS) (ST-elevation myocardial infarction [STEMI], non-STEMI, and unstable angina pectoris). HYPOTHESIS:Provided that ea...
journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验,收录出版
doi:10.1002/clc.20818
更新日期:2011-01-01 00:00:00
abstract::Despite the proven benefits of using antiplatelet therapy in patients undergoing percutaneous coronary intervention (PCI), a number of key questions remain to be answered. In recent years, clopidogrel dosing strategies among such patients have evolved considerably, with newer approaches involving loading doses prior t...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20359
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Brugada syndrome (BrS) is associated with sudden cardiac death (SCD). Although implantable cardioverter-defibrillator (ICD) implantation is recommended, the long-term outcomes and follow-up data with regard to ICD complications have led to controversy. HYPOTHESIS:In the present study, we described the data ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.23247
更新日期:2019-10-01 00:00:00
abstract::Computer interpretation of electrocardiograms is far from adequate. This paper highlights a particular type of computer error that is merely symbolic of the large number of errors the computer can make. In addition to computer errors in electrocardiography, it is likely that computer interpretation has diminished the ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190711
更新日期:1996-07-01 00:00:00
abstract::In the past decade, catheter ablation techniques and implantable devices have revolutionized the treatment of ventricular arrhythmias, junctional arrhythmias, and atrial flutter. For most patients presenting with atrial fibrillation (AF), the treatment available today is similar to that used a century ago, although no...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960200416
更新日期:1997-04-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20992
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Emerging biomarkers for acute myocardial infarction (AMI) may enhance conventional risk-prediction algorithms if they are informative and associated with risk independently of established predictors. In this study, we constructed a cohort for testing emerging biomarkers for AMI in managed-care populations us...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.22146
更新日期:2013-08-01 00:00:00