A systolic murmur is a common presentation of aortic regurgitation detected by echocardiography.

Abstract:

BACKGROUND:The finding of aortic regurgitation at a classical examination is a diastolic murmur. HYPOTHESIS:Aortic regurgitation is more likely to be associated with a systolic than with a diastolic murmur during routine screening by a noncardiologist physician. METHODS:In all, 243 asymptomatic patients (mean age 42 +/- 10 years) with no known cardiac disease but at risk for aortic valve disease due to prior mediastinal irradiation (> or = 35 Gy) underwent auscultation by a noncardiologist followed by echocardiography. A systolic murmur was considered benign if it was grade < or = II/VI, not holosystolic, was not heard at the apex, did not radiate to the carotids, and was not associated with a diastolic murmur. RESULTS:Of the patients included, 122 (49%) were male, and 86 (35%) had aortic regurgitation, which was trace in 20 (8%), mild in 52 (21%), and moderate in 14 (6%). A systolic murmur was common in patients with aortic regurgitation, occurring in 12 (86%) with moderate, 26 (50%) with mild, 6 (30%) with trace, and 27 (17%) with no aortic regurgitation (p < 0.0001). The systolic murmurs were classified as benign in 21 (78%) patients with mild and 8 (67%) with moderate aortic regurgitation. Diastolic murmurs were rare, occurring in two (14%) with moderate, two (4%) with mild, and three (2%) with no aortic regurgitation (p=0.15). CONCLUSIONS:An isolated systolic murmur is a common auscultatory finding by a noncardiologist in patients with moderate or milder aortic regurgitation. A systolic murmur in patients at risk for aortic valve disease should prompt a more thorough physical examination for aortic regurgitation.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Heidenreich PA,Schnittger I,Hancock SL,Atwood JE

doi

10.1002/clc.4960270905

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

502-6

issue

9

eissn

0160-9289

issn

1932-8737

journal_volume

27

pub_type

杂志文章
  • Should interventional cardiac catheterization procedures take place at the time of diagnostic procedures?

    abstract:BACKGROUND:In many cardiac catheterization laboratories interventional procedures are performed at a date later than the diagnostic study, causing increased hospital days and costs. Few data exist which compare procedural success, complications, and costs between procedures performed at the time of diagnostic study and...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960230505

    authors: Panchamukhi VB,Flaker GC

    更新日期:2000-05-01 00:00:00

  • The prevalence of prehypertension and hypertension among rural adults in Liaoning province of China.

    abstract:BACKGROUND:The objective of this study was to estimate the prevalence of prehypertension and hypertension in the rural adults of Liaoning province of China. METHODS:The study was conducted in 2004-2006, using a multistage cluster sampling method to select a representative sample. A total of 45925 adults, 35 years or o...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20073

    authors: Sun Z,Zheng L,Wei Y,Li J,Zhang X,Zhang X,Liu S,Xu C,Li J,Zhao F,Dong G,Hu D,Sun Y

    更新日期:2007-04-01 00:00:00

  • Relationship between cardiovascular disease knowledge and race/ethnicity, education, and weight status.

    abstract:BACKGROUND:Inadequate cardiovascular disease (CVD) knowledge has been cited to account for the imperfect decline in CVD among women over the last 2 decades. HYPOTHESIS:Due to concerns that at-risk women might not know the leading cause of death or symptoms of a heart attack, our goal was to assess the relationship bet...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20992

    authors: Giardina EG,Mull L,Sciacca RR,Akabas S,Flink LE,Moise N,Paul TK,Dumas NE,Bier ML,Mattina D

    更新日期:2012-01-01 00:00:00

  • The safety profile of quinapril: is there a difference among ACE inhibitors?

    abstract::The safety of quinapril hydrochloride, a new nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor with an intermediate duration of action, has been evaluated in 3,031 patients with hypertension and congestive heart failure (CHF) and has been compared with other ACE inhibitors. A comparison of double-blind studi...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960131408

    authors: Canter D,Frank GJ,Knapp LE,McLain RW

    更新日期:1990-06-01 00:00:00

  • In-hospital mortality of elderly patients with acute myocardial infarction: data from the MITRA (Maximal Individual Therapy in Acute Myocardial Infarction) registry.

    abstract:BACKGROUND:Advanced age remains one of the principal determinants of mortality in patients with acute myocardial infarction (AMI). HYPOTHESIS:The aim of this study was to determine the in-hospital outcome of elderly (> 75 years) patients with AMI who were admitted to hospitals participating in the national MITRA (Maxi...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960231109

    authors: Haase KK,Schiele R,Wagner S,Fischer F,Burczyk U,Zahn R,Schuster S,Senges J

    更新日期:2000-11-01 00:00:00

  • Nicardipine, a new calcium channel blocker: role for vascular selectivity.

    abstract::Calcium channel blockers are important drugs for the treatment of chronic stable angina. However, negative inotropic and dromotropic effects may limit their usefulness in patients with atrioventricular conduction abnormalities or left ventricular dysfunction. A new generation of calcium channel blockers will soon be a...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章,评审

    doi:10.1002/clc.4960120503

    authors: Pepine C

    更新日期:1989-05-01 00:00:00

  • Efficacy and safety of clentiazem in patients with essential hypertension: results of an early pilot test.

    abstract::The purpose of this study was to evaluate the antihypertensive effect of a new calcium antagonist, clentiazem, on inpatients or outpatients with essential hypertension. After blood pressure was stable and greater than 160/95 mmHg with placebo for at least a 2-week observation period, oral clentiazem was administered o...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/clc.4960140112

    authors: Kawakita S,Kinoshita M,Ishikawa H,Kagoshima T,Katori R,Ishikawa K,Hirota Y

    更新日期:1991-01-01 00:00:00

  • SMARTWOMAN™: Feasibility assessment of a smartphone app to control cardiovascular risk factors in vulnerable diabetic women.

    abstract:BACKGROUND/HYPOTHESIS:SMARTWOMAN™ was designed to develop and assess the feasibility of a smartphone app to control cardiovascular risk factors in vulnerable diabetic women. METHODS:Fourteen African-American women with diabetes and without known cardiovascular disease were enrolled. A weight-scale, glucometer, sphygmo...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.23124

    authors: Wenger NK,Williams OO,Parashar S

    更新日期:2019-02-01 00:00:00

  • Losartan and end-organ protection--lessons from the RENAAL study.

    abstract:BACKGROUND:The Reduction in ENdpoints with the Angiotensin Antagonist Losartan (RENAAL) study reported that losartan delayed the progression of renal disease in patients with type 2 diabetes and nephropathy. Diabetic or renally impaired patients are at high cardiovascular risk, a risk potentially increased in patients ...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1002/clc.4960280307

    authors: Kowey PR,Dickson TZ,Zhang Z,Shahinfar S,Brenner BM,RENAAL Investigators.

    更新日期:2005-03-01 00:00:00

  • Electrocardiographic predictors of right ventricular volume measured by magnetic resonance imaging late after total repair of tetralogy of Fallot.

    abstract:BACKGROUND:Right ventricular dysfunction occurs in many patients with significant pulmonary valve regurgitation late after initial total repair of tetralogy of Fallot. Methods to predict which of these patients are at increased risk of late morbidity and mortality are not yet known. HYPOTHESIS:This study evaluated ele...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960221113

    authors: Book WM,Parks WJ,Hopkins KL,Hurst JW

    更新日期:1999-11-01 00:00:00

  • Association between anxiety and clinical outcomes in Chinese patients with myocardial infarction in the absence of obstructive coronary artery disease.

    abstract:BACKGROUND:Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) accounts for approximately 5% - 6% of acute myocardial infarction (AMI) patients. Anxiety symptoms are common in patients with coronary artery disease (CAD), and are associated with a poor prognosis. However, the association...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.23386

    authors: He CJ,Zhu CY,Han B,Hu HZ,Wang SJ,Zhai CL,Hu HL

    更新日期:2020-07-01 00:00:00

  • QTc interval evaluation in patients with right bundle branch block or bifascicular blocks.

    abstract:BACKGROUND:The right bundle branch block (RBBB) and the bifascicular blocks affect QRS duration in the right precordial leads, which are usually used for QT interval determination. Up to now, there is no clear recommendation how to determine QT interval in patients with RBBB or bifascicular block. HYPOTHESIS:The hypot...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.23389

    authors: Erkapic D,Frommeyer G,Brettner N,Sözener K,Crijns HJGM,Seyfarth M,Hamm CW,Bogossian H

    更新日期:2020-09-01 00:00:00

  • Elevated serum cardiac troponin in non-acute coronary syndrome.

    abstract::Cardiac troponins (CTn) are the most sensitive and specific biochemical markers of myocardial injury and risk stratification. The assay for troponin T (cTnI) is standardized, and results obtained from different institutions are comparable. This is not the case with troponin I (cTnT), and clinicians should be aware tha...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.20445

    authors: Agzew Y

    更新日期:2009-01-01 00:00:00

  • What do the 2011 American Heart Association guidelines tell us about prevention of cardiovascular disease in women?

    abstract::The 2011 Update of the American Heart Association's Cardiovascular Disease Prevention Guideline for Women is designed to help women and their physicians understand cardiovascular Disease (CVD) risks and undertake practical steps that are most effective in preventing heart disease and stroke. Defining a woman's risk st...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.20940

    authors: Wenger NK

    更新日期:2011-09-01 00:00:00

  • Clinical considerations with the use of antiplatelet therapy in patients undergoing percutaneous coronary intervention.

    abstract::Despite the proven benefits of using antiplatelet therapy in patients undergoing percutaneous coronary intervention (PCI), a number of key questions remain to be answered. In recent years, clopidogrel dosing strategies among such patients have evolved considerably, with newer approaches involving loading doses prior t...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.20359

    authors: Braunwald E,Angiolillo D,Bates E,Berger PB,Bhatt D,Cannon CP,Furman MI,Gurbel P,Michelson AD,Peterson E,Wiviott S

    更新日期:2008-03-01 00:00:00

  • Relation of body fluid status to B-type natriuretic peptide levels in patients with chronic heart failure during long-term follow-up.

    abstract:BACKGROUND:Little is known about the relationship of body fluid status with the levels and fluctuations of B-type natriuretic peptide (BNP) over the long-term. HYPOTHESIS:If BNP is to become useful for monitoring of patients with chronic heart failure (HF), the levels should reliably reflect both decompensation and im...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960291008

    authors: Kataoka H

    更新日期:2006-10-01 00:00:00

  • Rationale and design of the BAYES (Interatrial Block and Yearly Events) registry.

    abstract::The prevalence of interatrial block (IAB) is high in the elderly, particularly in those with heart disease. Despite this high prevalence-and the association of IAB with the risk of atrial fibrillation (AF), stroke, and cognitive decline-little information exists about the prognosis of older patients with IAB. P-wave d...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/clc.22647

    authors: Martínez-Sellés M,Baranchuk A,Elosua R,de Luna AB

    更新日期:2017-04-01 00:00:00

  • Heart rate and catecholamine contribution to QT interval shortening on exercise.

    abstract:BACKGROUND:QT interval shortens with exercise. Some of this shortening is due to an increase in heart rate, and some is due to other effects of exercise, probably mostly neuroendocrine effects. Data from subjects with cardiac transplants have suggested that non-heart rate-related changes in QT interval on exercise are ...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/clc.4960220805

    authors: Davey P,Bateman J

    更新日期:1999-08-01 00:00:00

  • Practical algorithms for pharmacologic management of the post myocardial infarction patient.

    abstract::The pharmacologic management of the patient post myocardial infarction (MI) aims to achieve several goals. Chief among these is to prevent subsequent events, which include death, reinfarction, and rehospitalization. Secondary goals include preventing arrhythmias, minimizing left ventricular (LV) remodeling, and preven...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960281306

    authors: Reiffel JA,American Heart Association.,American College of Cardiology.

    更新日期:2005-11-01 00:00:00

  • Hypercholesterolemia paradox in relation to mortality in acute coronary syndrome.

    abstract:BACKGROUND:Hypercholesterolemia is a risk factor for coronary artery disease, yet is associated with lower risk of adverse outcomes in patients with acute coronary syndromes (ACS). HYPOTHESIS:We explored this paradox in 84,429 patients with non-ST-segment elevation ACS in the Can Rapid Risk Stratification of Unstable ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20518

    authors: Wang TY,Newby LK,Chen AY,Mulgund J,Roe MT,Sonel AF,Bhatt DL,DeLong ER,Ohman EM,Gibler WB,Peterson ED

    更新日期:2009-09-01 00:00:00

  • Factors associated with the release of cardiac troponin T following percutaneous transluminal coronary angioplasty.

    abstract:BACKGROUND:Recent studies have suggested that immunoassay of cardiac troponin T (cTnT) provides a more sensitive measurement of myocardial necrosis than creatine kinase MB (CK-MB) mass concentration. HYPOTHESIS:The purpose of this study was to compare the release of cTnT and CK-MB isoenzyme in patients undergoing perc...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960191005

    authors: Abbas SA,Glazier JJ,Wu AH,Dupont C,Green SF,Pearsall LA,Waters DD,McKay RG

    更新日期:1996-10-01 00:00:00

  • Statin therapy in the reduction of cardiovascular events in patients undergoing intermediate-risk noncardiac, nonvascular surgery.

    abstract:BACKGROUND:Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) reduce perioperative cardiac events in high-risk patients undergoing cardiovascular surgery. However, there is paucity of data on the role of statins in patients undergoing intermediate-risk noncardiac, nonvascular surgery (NCNVS). HYPOTHESIS:S...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22135

    authors: Raju MG,Pachika A,Punnam SR,Gardiner JC,Shishehbor MH,Kapadia SR,Abela GS

    更新日期:2013-08-01 00:00:00

  • Metastatic cardiac malignant fibrous histiocytoma presenting as right ventricular outflow tract obstruction.

    abstract::An unusual case of metastatic disease of the right ventricle is described in a 74-year-old woman who had presented with a malignant fibrous histiocytoma of the right thigh previously treated with surgery and radiotherapy. Two years later she presented with signs and symptoms of tricuspid regurgitation and right ventri...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960140216

    authors: Kamlow FJ,Padaria SF,Wainwright RJ

    更新日期:1991-02-01 00:00:00

  • The importance of pre- and postinfarction angina on timolol-related reduction in mortality and reinfarction.

    abstract::The importance of a history of angina pectoris on long-term timolol treatment after myocardial infarction was studied with respect to mortality and reinfarction. The analyses were performed retrospectively using cohorts from the Norwegian timolol multicenter study. In patients without angina pectoris prior to the infa...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1002/clc.4960080205

    authors: Gundersen T,Kjekshus J

    更新日期:1985-02-01 00:00:00

  • Percutaneous mitral commissurotomy using the metallic valvulotome technique in a critically ill adult.

    abstract::A 25-year-old man presented with cardiogenic shock secondary to rheumatic mitral stenosis. Despite aggressive medical treatment he continued to deteriorate. This report describes the successful use of the metallic valvulotome technique for mitral commissurotomy in the context of a critically ill patient. ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960270616

    authors: Ward DE,Tanner MA

    更新日期:2004-06-01 00:00:00

  • Determinants and prognostic implications of reperfusion injury during primary percutaneous coronary intervention in Chinese patients with acute myocardial infarction.

    abstract:BACKGROUND:The poor clinical outcome in acute myocardial infarction (AMI) patients undergoing primary percutaneous coronary intervention (PCI) has been attributed to myocardial ischemia-reperfusion injury (MIRI). OBJECTIVE:This study aimed to identify the predictive factors of MIRI during PCI in Chinese AMI patients w...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20294

    authors: Luo Y,Li GL,Pan YZ,Zhou SF

    更新日期:2009-03-01 00:00:00

  • Women with high exercise tolerance and the role of myocardial perfusion imaging.

    abstract:BACKGROUND:Myocardial perfusion imaging (MPI) provides incremental diagnostic and prognostic information, even in patients with high exercise tolerance. HYPOTHESIS:Myocardial perfusion imaging provides significant diagnostic value, specifically in women with high exercise tolerance. METHODS:Our study population consi...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960240611

    authors: Chatziioannou SN,Moore WH,Dhekne RD,Ford PV

    更新日期:2001-06-01 00:00:00

  • The inaccuracy of aortic valve systolic flutter as a screening test for significant aortic stenosis.

    abstract::The noninvasive assessment of the severity of aortic stenosis is difficult. A recent description of systolic flutter of aortic valve leaflets as a screening test for severe aortic stenosis was applied to a group of patients who had undergone catheterization. As opposed to the previous report, we found this an inaccura...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960070407

    authors: Vacek JL,Phelix J,Rycyna JL

    更新日期:1984-04-01 00:00:00

  • Unloading the right ventricle in the CREST syndrome variant of progressive systemic sclerosis (scleroderma).

    abstract::A patient with severe pulmonary hypertension secondary to the CREST syndrome variant of scleroderma is described. Acute reductions in both pulmonary artery pressure and total pulmonary resistance were seen with nifedipine and oxygen administration. Reductions in resistance were maintained for over one month with this ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960070111

    authors: Morrison D,Goldman S,Alepa FP

    更新日期:1984-01-01 00:00:00

  • Conversion of infarction-associated atrial fibrillation by restoration of atrial perfusion.

    abstract::We report a patient who presented with new onset atrial fibrillation in the setting of inferior ST-segment elevation myocardial infarction (STEMI). Cardiac catheterization revealed proximal occlusion of the left circumflex artery. Balloon angioplasty and stenting restored flow to a large left atrial branch, with promp...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20573

    authors: Blanton RM,Nappi A,Kimmelstiel CD

    更新日期:2010-12-01 00:00:00