Abstract:
BACKGROUND:The global T-inversion (GTI) electrocardiogram (ECG) is strikingly abnormal with major QTc prolongation, but with a surprisingly good prognosis by Kaplan-Meier curve. This contrasts with most significant QTc prolongations. HYPOTHESIS:This study was undertaken to ascertain QT interval dispersion (QTd) in global T wave inversion, a clinically benign long QTc ECG. METHODS:Longest and shortest QT intervals in all 12 leads in 35 consecutive patients with GTI were determined by two mutually blinded observers. QTd was determined by subtraction (maximum-minimum) and QTc was calculated using the Bazett formula. RESULTS:There was a 2:1 female preponderance QTc was prolonged and equal for men (0.471) and women (0.469). Observer variability of under 2% permitted averaging of QT measurements. Composite mean QTd was 55 ms. The literature revealed a range of QTd in normal subjects of 39 to 59 ms (mostly 49 to 59 ms). Patient series with abnormal QTd were well above this level. CONCLUSION:Despite a strikingly abnormal ECG with marked QTc prolongation, QT dispersion was limited in global T inversion, consistent with its previously demonstrated benignity.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Desai SA,Mehrok S,Spodick DHdoi
10.1002/clc.4960221012subject
Has Abstractpub_date
1999-10-01 00:00:00pages
655-7issue
10eissn
0160-9289issn
1932-8737journal_volume
22pub_type
杂志文章abstract::The purpose of this study was to evaluate the antihypertensive effect of a new calcium antagonist, clentiazem, on inpatients or outpatients with essential hypertension. After blood pressure was stable and greater than 160/95 mmHg with placebo for at least a 2-week observation period, oral clentiazem was administered o...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1991-01-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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