Abstract:
:The purpose of this study was to evaluate the antihypertensive effect of a new calcium antagonist, clentiazem, on inpatients or outpatients with essential hypertension. After blood pressure was stable and greater than 160/95 mmHg with placebo for at least a 2-week observation period, oral clentiazem was administered once daily and dosage was increased stepwise from 10 to 40 mg over 10 weeks. Blood pressure significantly decreased by the second week of the study, and this hypotensive effect was maintained until the eighth week. Cumulative effective rate (percent of patients whose blood pressure decreased in 20/10 mmHg) in 62 outpatients were as follows; 10.3% at 10 mg, 39.6% at 20 mg, 70.2% at 30 mg, 76.6% at 40 mg. There was no significant postural change observed in the blood pressure from supine to standing position. Side effects such as dizziness, general malaise and gait disturbances were observed in 3 (3.9%) of 76 patients. No abnormal changes in clinical laboratory examinations or electrocardiograms were caused by clentiazem. Thus these data demonstrated that clentiazem produces certain antihypertensive effects with sufficient safety.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Kawakita S,Kinoshita M,Ishikawa H,Kagoshima T,Katori R,Ishikawa K,Hirota Ydoi
10.1002/clc.4960140112subject
Has Abstractpub_date
1991-01-01 00:00:00pages
53-60issue
1eissn
0160-9289issn
1932-8737journal_volume
14pub_type
临床试验,杂志文章,多中心研究abstract::The incidence of inadvertent permanent ventricular pacing from the coronary vein is not known. In a retrospective analysis of 69 patients in whom transvenous pacemakers were implanted between 1979 and 1986, 12 patients were discovered to have right bundle-branch block pattern to the paced complexes on electrocardiogra...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120508
更新日期:1989-05-01 00:00:00
abstract::The pseudoaneurysm is a rare cardiac pathology, in which the left ventricular free wall ruptures and the pericardium surrounds the rupture in combination with thrombus and inflammation and thus prevents the development of a hemopericardium. Left ventricular pseudoaneurysm may remain silent unless it gives rise to card...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20311
更新日期:2009-06-01 00:00:00
abstract::Coronary collateral perfusion to the completely obstructed coronary artery was evaluated by coronary cineangiography in 32 patients. In 13 patients, there was neither history of severe chest pain of longer than 30-min duration nor electrocardiographic evidence of a transmural myocardial infarction (Group I). Among pat...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100705
更新日期:1987-07-01 00:00:00
abstract::Recommendations in the 2007 update of the American College of Cardiology/American Heart Association guidelines for patients with non-ST-elevation myocardial infarction (NSTEMI) provide considerable latitude regarding treatment choices and care pathways. Nevertheless, as accumulating evidence leads to increased recomme...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20671
更新日期:2009-11-01 00:00:00
abstract::To analyze the paradox of acute myocardial infarction (AMI) with an initially normal electrocardiogram (ECG), we reviewed the records of 732 patients discharged with a final diagnosis of AMI over a 2-year period. Twenty-one patient were identified whose initial ECG was normal and who underwent coronary arteriography d...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960181006
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:The relationship between eicosapentaenoic acid (EPA) therapy and coronary plaque stability assessed by optical frequency domain imaging (OFDI) has not been thoroughly described. HYPOTHESIS:EPA therapy is associated with decreased plaque instability in patients undergoing percutaneous coronary intervention (...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23185
更新日期:2019-06-01 00:00:00
abstract::The use of nisoldipine (10-20 mg b.i.d.) was evaluated as a replacement therapy for long-acting nifedipine (40-120 mg/day) in 21 patients with severe hypertension, who were resistant to or intolerant of nifedipine. Except for one patient with specific contraindications, all participants received an individually determ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110510
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:The extracellular matrix tissue of the myocardium importantly contributes to left ventricular (LV) performance. Inherited connective tissue disorders related to the FBN1 gene could involve cardiac interstitium resulting in functional abnormalities. HYPOTHESIS:To disclose a primary involvement of myocardium,...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960250905
更新日期:2002-09-01 00:00:00
abstract::Despite advances in the treatment of congestive heart failure (CHF), the mortality rate continues to be high. A large number of the deaths are sudden, presumably due to ventricular arrhythmias. Complex ventricular arrhythmias are recorded in as many as 80% of patients with CHF, with nonsustained ventricular tachycardi...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960120910
更新日期:1989-09-01 00:00:00
abstract::To enhance the bedside diagnosis of tricuspid regurgitation, the influence of manual pressure applied below the liver on lower left sternal border murmurs was determined in 23 patients. All 23 subjects had right ventriculograms and right atrial phonocardiograms. The sign was positive in 13 cases, including 3 who were ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960060605
更新日期:1983-06-01 00:00:00
abstract::Recently two types of atypical T-wave evolution were recognized as electrocardiographic (ECG) markers of regional postinfarction pericarditis. The sensitivity and specificity of these changes for this condition were 100 and 77%, respectively. The major purpose of this investigation is to show how these ECG changes can...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170903
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Obesity can lead to increased oxidative stress which is one of the proposed mechanisms in the etiopathogenesis of takotsubo cardiomyopathy (TCM). HYPOTHESIS:The presence of obesity adversely impacts clinical outcomes in TCM patients. METHODS:We queried the Nationwide Inpatient Sample database (2010-2014) t...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.22999
更新日期:2018-08-01 00:00:00
abstract::Primary tumors of the heart are infrequent at all ages. We present a newborn with hypoxia and a heart murmur, in whom an echocardiogram revealed a large tumor filling the right ventricle and the pulmonary annulus. To maintain pulmonary blood flow, the patency of the ductus arteriosus was achieved by infusion of prosta...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110910
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:Increased salt intake may induce hypertension, lead to cardiac hypertrophy, and exacerbate heart failure. When elderly patients develop heart failure, diastolic dysfunction is often observed, although the ejection fraction has decreased. Diabetes mellitus (DM) is an established risk factor for heart failure....
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20664
更新日期:2009-10-01 00:00:00
abstract::The 2011 Update of the American Heart Association's Cardiovascular Disease Prevention Guideline for Women is designed to help women and their physicians understand cardiovascular Disease (CVD) risks and undertake practical steps that are most effective in preventing heart disease and stroke. Defining a woman's risk st...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.20940
更新日期:2011-09-01 00:00:00
abstract::Although certain classes of drugs appear to possess benefits apart from their blood-pressure lowering capability, reduction of blood pressure remains the single most important action of antihypertensive therapy. Calcium-channel blockers (CCBs) have long been recognized as potent agents for hypertension therapy. This i...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960261404
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:ST-segment depression during acute myocardial infarction (AMI) is known to herald serious hemodynamic complications. Since the mechanism of this dependence is not clear, we reinvestigated the old concept of papillary muscle infarction (PMI) as a cause of marked ST depression. METHODS:Autopsie...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190514
更新日期:1996-05-01 00:00:00
abstract::The case of a 73-year-old man with right heart failure and systolic and diastolic murmur at the fourth left intercostal space is described. There was a history of rheumatic fever. Two-dimensional echocardiography showed rheumatic change of the tricuspid valve with giant right atrium and ventricle, which was confirmed ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090710
更新日期:1986-07-01 00:00:00
abstract::Cardiac dysfunction, including mitral valve regurgitation and congestive heart failure, can occur in patients with sickle cell disease. However, major surgery poses a greater risk in this population. This paper reports on the management of a patient with sickle cell disease who underwent successful replacement of the ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960210814
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Management of cardiac perforation caused by the lead of a cardiac implantable electronic device (CIED) is currently unclear. This study evaluated the outcomes of transvenous lead extraction (TLE) in patients with cardiac perforation caused by a transvenous lead. HYPOTHESIS:Removal of perforated lead by tran...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23327
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Giant cell arteritis (GCA) is an inflammatory disease of unknown etiology affecting adults age > 50 years. GCA (also known as temporal arteritis) is a vasculitis of large and medium-size vessels that involves the extracranial branches of the carotid artery. Common manifestations include constitutional sympto...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22927
更新日期:2018-05-01 00:00:00
abstract::Paravalvular regurgitation (PVR) remains one of the drawbacks of transcatheter aortic valve implantation (TAVI). Details of percutaneous closure (PCC) of PVR after TAVI remain obscure. We aimed to explore the patient characteristics, procedural details, closure devices used, and outcomes of PCC after TAVI. A systemati...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22569
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:In clinical cardiology, heart rate variability is a putative index of autonomic cardiovascular function. Signs of reduced vagal activity are not only associated with an enhanced risk of sudden cardiac death, but such impaired heart rate variability became a new predictor of sudden cardiac death and other mor...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960200710
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Coronary artery disease (CAD) risk is not fully revealed by traditional risk factors. Identification of a simple, noninvasive tool that allows for detection of high-risk CAD patients and can be applied in large populations and clinical settings would prove valuable. HYPOTHESIS:We sought to test the hypothes...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20705
更新日期:2010-02-01 00:00:00
abstract::The long-term survival rate following acute myocardial infarction (AMI) was studied in 358 patients in central Japan who were monitored for 8 to 20 years after discharge from hospital for AMI. Fifteen-year cardiac survival rates were 65% in males and 72% in females. In both sexes, the survival rate decreased with incr...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120905
更新日期:1989-09-01 00:00:00
abstract::Aspirin is integral in the primary and secondary prevention of coronary artery disease and acute coronary syndrome. Given the high clinical importance of aspirin in the management of coronary artery disease, much attention has been directed towards the concept of "aspirin resistance." Unfortunately, the term aspirin r...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22031
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Although suppression of premature ventricular contractions (PVCs) is not a predictor of mortality over the long term, the extent of PVC suppression is an important characteristic of any antiarrhythmic drug. HYPOTHESIS:This study was undertaken to determine whether intravenous (i.v.) dofetilide has the abili...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960230607
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:In patients with stable angina pectoris, eccentric stenoses have a greater potential for dynamic changes of caliber in response to vasoactive stimuli than concentric lesions. It is not known whether in patients with coronary artery spasm the degree of coronary vasoconstriction differs in eccen...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960210907
更新日期:1998-09-01 00:00:00
abstract::This report describes the development of a quality assurance-oriented integrated software system designed for an anesthesiology-based intraoperative transesophageal echocardiography service. Entry data include patient and operation demographics, two-dimensional echocardiographic, saline-contrast, and color flow/pulsed...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960161012
更新日期:1993-10-01 00:00:00
abstract::Therapy for acute myocardial infarction has advanced dramatically since the early 1980s with the use of early intravenous fibrinolytic therapy. Combining low-dose fibrinolysis and platelet lysis appears to provide an additional increase in infarct-related artery (IRA) patency, but the large-scale mortality reduction t...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960221605
更新日期:1999-08-01 00:00:00