Efficacy and safety of clentiazem in patients with essential hypertension: results of an early pilot test.

Abstract:

:The purpose of this study was to evaluate the antihypertensive effect of a new calcium antagonist, clentiazem, on inpatients or outpatients with essential hypertension. After blood pressure was stable and greater than 160/95 mmHg with placebo for at least a 2-week observation period, oral clentiazem was administered once daily and dosage was increased stepwise from 10 to 40 mg over 10 weeks. Blood pressure significantly decreased by the second week of the study, and this hypotensive effect was maintained until the eighth week. Cumulative effective rate (percent of patients whose blood pressure decreased in 20/10 mmHg) in 62 outpatients were as follows; 10.3% at 10 mg, 39.6% at 20 mg, 70.2% at 30 mg, 76.6% at 40 mg. There was no significant postural change observed in the blood pressure from supine to standing position. Side effects such as dizziness, general malaise and gait disturbances were observed in 3 (3.9%) of 76 patients. No abnormal changes in clinical laboratory examinations or electrocardiograms were caused by clentiazem. Thus these data demonstrated that clentiazem produces certain antihypertensive effects with sufficient safety.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Kawakita S,Kinoshita M,Ishikawa H,Kagoshima T,Katori R,Ishikawa K,Hirota Y

doi

10.1002/clc.4960140112

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

53-60

issue

1

eissn

0160-9289

issn

1932-8737

journal_volume

14

pub_type

临床试验,杂志文章,多中心研究
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    pub_type: 杂志文章,多中心研究

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    pub_type: 临床试验,杂志文章

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    pub_type: 临床试验,杂志文章,随机对照试验

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