Abstract:
:The treatment of hypertension continues to be challenging due to the lack of understanding regarding underlying modulators of blood pressure as well as co-existing conditions such as atherosclerosis and diabetes. This has led to uncertainty regarding treatment strategy and intensity. The INternational VErapamil SR/trandolapril STudy (INVEST) is designed to evaluate the relationship between cardiovascular risk and blood pressure modulators. Based on a review of preliminary data, it appears that the treatment regimen used in the INVEST trial has been more successful than other studies at controlling systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure. These preliminary data from INVEST suggest that a high proportion of coronary artery disease (CAD) patients with hypertension should receive combination therapy to achieve contemporary blood pressure targets.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Kolloch REdoi
10.1002/clc.4960241705subject
Has Abstractpub_date
2001-11-01 00:00:00pages
V12-3issue
11 Suppleissn
0160-9289issn
1932-8737journal_volume
24pub_type
杂志文章abstract::The effects of monotherapy with atenolol or diltiazem-SR on blood pressure, 24-h blood pressure (BP) load, and exercise capacity were tested in patients with mild to moderate (stages I and II) essential hypertension. After 3-week single-blind placebo therapy, patients with sitting diastolic blood pressure (SDBP) of 94...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960171209
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Contraction-excitation feedback, that is, electrophysiologic changes that are caused or preceded by mechanical changes of the myocardium, has been extensively studied in the ventricles. The role of contraction-excitation feedback in the atria, and more particularly in the genesis and maintenance of atrial fi...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960200514
更新日期:1997-05-01 00:00:00
abstract::Thrombotic obstruction of aortic bioprostheses is rare. Few cases have been reported involving the use of the Carpentier-Edwards (CE) prosthesis, the Hancock bioprosthesis, or the Medtronic Intact porcine valve. Thrombolytic therapy for mechanical valve thrombosis has been used frequently even though it is known to ca...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960160215
更新日期:1993-02-01 00:00:00
abstract::In the past, many have avoided nuts because of their high fat content. The Dietary Approaches to Stop Hypertension (DASH) diet, however, recommends regular consumption of this food along with seeds and dried beans (4-5 servings per week) as part of a diet to control hypertension. Nuts are nutrient-dense and most of th...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960221504
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Familial hypercholesterolemia (FH) is a common autosomal dominant disease associated with premature coronary heart disease (CHD). Studies tend to show that patients with FH associated with an identified mutation (mutation+ FH) are at higher risk than patients without an identified mutation (mutation- FH). We...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22881
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Vasovagal syncope (VVS) is a common cause of recurrent syncope. Nevertheless, the exact hemodynamic mechanism has not been elucidated. Pulse wave analysis (PWA) is widely used to evaluate vascular properties, as it reflects the condition of the entire arterial system. HYPOTHESIS:Cardiovascular autonomic mod...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23380
更新日期:2020-07-01 00:00:00
abstract::Scorpion envenomation is quite common in India, southeast Asia, the U.S. southwest, and Israel (in the Negev and around Jerusalem). Yellow scorpion is considered the most dangerous scorpion that causes cardiac toxicity. Two patients are described, who lived in a nonendemic area of yellow scorpions and were envenomated...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960150514
更新日期:1992-05-01 00:00:00
abstract::Nicardipine a second-generation dihidropyridine calcium antagonist, has been approved in oral formulation for use in the United States, and is under review for parenteral use. Nicardipine is the most vascular-selective agent of this class currently approved and should, on theoretical grounds, be ideal for combination ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960150403
更新日期:1992-04-01 00:00:00
abstract::Nonpharmacologic therapies for patients with sustained ventricular tachycardia have been necessitated by the low frequency of drug-responsive patients. These nonpharmacologic therapies include antitachycardia pacemakers, low-energy cardioverters, defibrillators, surgery and, for the present, catheter ablation. Antitac...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Stimulated endothelium-derived relaxing factor-mediated vasodilation and conduit artery distensibility are impaired in congestive heart failure (CHF). L-arginine could have a potentially beneficial role in CHF, acting through the nitric oxide (NO)-L-arginine pathway or by growth hormone increment. HYPOTHESI...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960230314
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Cardiac injury is common in COVID-19 patients and is associated with increased mortality. However, it remains unclear if reduced cardiac function is associated with cardiac injury, and additionally if mortality risk is increased among those with reduced cardiac function in COVID-19 patients. HYPOTHESIS:The ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23479
更新日期:2020-12-01 00:00:00
abstract::In 1350 patients with suspected acute myocardial infarction, serum potassium levels during the first 3 days in hospital was correlated to clinical history and clinical course. A higher incidence of hypokalemia was observed in women, in patients with hypertension, and in those on chronic diuretic treatment. Patients wi...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960111005
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:Sex-based differences in acute coronary syndrome (ACS) mortality may attenuate with age due to better symptom recognition and prompt care. HYPOTHESIS:Age is a modifier of temporal trends in sex-based differences in ACS care. METHODS:Among 104 817 eligible patients with ACS enrolled in the AHA Get With the ...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.22938
更新日期:2018-06-01 00:00:00
abstract::Two cases with acute myocardial infarction are presented. Both had thrombotic occlusion of the infarct-related artery. Following successful thrombolysis with streptokinase, coronary angiography was normal. These cases prove that "myocardial infarction with normal coronaries" can be associated with coronary thrombosis ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960061107
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:The real-world impact of remote pulmonary artery pressure (PAP) monitoring on New York Heart Association (NYHA) class improvement and heart failure (HF) hospitalization rate is presented here from a single center. HYPOTHESIS:METHODS: Seventy-seven previously hospitalized outpatients with NYHA class III HF w...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22643
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) is a major problem in developed countries. However, its relationship with obesity remains unclear, especially in low-risk populations. The objective of the study was to analyze the relationship between obesity and HF in a low-risk Mediterranean population. HYPOTHESIS:Obesity is an indepen...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.20837
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Congestive heart failure is the most common cause of mortality in patients with end-stage renal disease (ESRD). However, noninvasive assessment for cardiac involvement in ESRD has not been established. HYPOTHESIS:Assessment of ultrasonic tissue characterization and serum markers of collagen degradation is u...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270412
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Plaque rupture with subsequent transient thrombotic coronary occlusion by a fast-dissolving clot is one of the proposed pathogenic mechanisms in Takotsubo cardiomyopathy (TC). HYPOTHESIS:The aim of this study was to seek evidence for the hypothesis of transient coronary thrombosis as the underlying mechanis...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20747
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Hypercholesterolemia is a risk factor for coronary artery disease, yet is associated with lower risk of adverse outcomes in patients with acute coronary syndromes (ACS). HYPOTHESIS:We explored this paradox in 84,429 patients with non-ST-segment elevation ACS in the Can Rapid Risk Stratification of Unstable ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20518
更新日期:2009-09-01 00:00:00
abstract::The serum concentration of several lipids, including high-density lipoprotein-cholesterol (HDL-C) and the HDL subfractions, HDL-2-C and HDL-3-C, were measured in 44 male and 26 female survivors of myocardial infarction and compared with those of a control group matched for age, sex, and body weight. Serum concentratio...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090608
更新日期:1986-06-01 00:00:00
abstract::In 2009, much was written about computed tomography (CT) angiography of the coronary circulation and little about catheter-based coronary angiography, despite its continued use since 1958 in patients with all types of cardiac disease or potential disease. ...
journal_title:Clinical cardiology
pub_type: 评论,社论
doi:10.1002/clc.20741
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is a complex cardiac arrhythmia in clinical practice with increasing incidence. However, the effects of statins on patients with AF are not quite clear. HYPOTHESIS:To investigate the protective effect of calcium channel blocker (CCB) and valsartan combined fluvastatin on hypertensio...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23487
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:For patients with ST elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI), rapid restoration of coronary blood flow is the primary therapeutic goal. Because of the acute nature of this clinical presentation, bleeding risks may not be adequately evaluated, limiting the us...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20295
更新日期:2009-06-01 00:00:00
abstract::Aspirin is integral in the primary and secondary prevention of coronary artery disease and acute coronary syndrome. Given the high clinical importance of aspirin in the management of coronary artery disease, much attention has been directed towards the concept of "aspirin resistance." Unfortunately, the term aspirin r...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22031
更新日期:2012-11-01 00:00:00
abstract::We report a patient with controlled atrial fibrillation-flutter (AFF) and mitral stenosis who developed a marked increase in atrioventricular conduction during an infusion of low dose dopamine with development of hemodynamic compromise. This side effect has not been previously described in humans. Dopamine infusion sh...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960101114
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Disruption of the atherosclerotic plaque is a common feature of both acute coronary syndromes and balloon dilatation of coronary artery stenoses. HYPOTHESIS:The study was undertaken to evaluate whether the known association of cholesterol levels and acute coronary syndromes also exists for the occurrence of...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4950260708
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:While depressed left ventricular ejection fraction is clearly associated with poor long-term outcome in heart failure (HF), the effect of ejection fraction on short-term outcomes and resource utilization following hospitalization for HF remains unclear. HYPOTHESIS:We evaluated the independent effect of depr...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220306
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Compared with medical therapy, percutaneous coronary intervention (PCI) does not reduce mortality or myocardial infarction in patients with stable angina. Therefore, PCI should be guided by refractory anginal symptoms and not just lesion characteristics. HYPOTHESIS:We hypothesized that angiographic lesion c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22510
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Myocardial blush grade (MBG), corrected TIMI frame count (cTFC), and ST-segment reduction are indices of myocardial reperfusion. HYPOTHESIS:We evaluated their predictive value for left ventricular (LV) function recovery by gated single-photon emission computed tomography (SPECT) after acute myocardial infar...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960271205
更新日期:2004-12-01 00:00:00
abstract::In a series of 20 coronary excimer laser angioplasties, two patients presented with a peculiar type of malignant restenosis 6 and 8 weeks after a successful laser angioplasty procedure. One patient had a successful recanalization of an occluded left anterior descending (LAD) coronary artery and the second patient had ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960130606
更新日期:1990-06-01 00:00:00