Abstract:
:Nicardipine a second-generation dihidropyridine calcium antagonist, has been approved in oral formulation for use in the United States, and is under review for parenteral use. Nicardipine is the most vascular-selective agent of this class currently approved and should, on theoretical grounds, be ideal for combination therapy with beta-adrenergic blocking agents. Studies have shown that the combination of nicardipine and beta-blocking agents offers additional efficacy over monotherapy with either agent alone. The hemodynamic profile of combination therapy appears to be especially favorable in patients with diminished left ventricular function needing therapy with agents of both classes. Adverse effects are few and may be improved compared with other agents of the dihidropyridine class.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Lambert CRdoi
10.1002/clc.4960150403subject
Has Abstractpub_date
1992-04-01 00:00:00pages
231-4issue
4eissn
0160-9289issn
1932-8737journal_volume
15pub_type
杂志文章,评审abstract::Computer interpretation of electrocardiograms is far from adequate. This paper highlights a particular type of computer error that is merely symbolic of the large number of errors the computer can make. In addition to computer errors in electrocardiography, it is likely that computer interpretation has diminished the ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190711
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Transesophageal echocardiography (TEE) has been used to identify the potential risk for cardiogenic embolism in patients with atrial fibrillation (AF). However, ischemic stroke in patients with AF is not always attributable to embolism. Identification of the risk of embolic versus atherothrombotic stroke sho...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960230710
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Most information concerning hypertrophic cardiomyopathy has been derived from western countries and Japan. HYPOTHESIS:Patients with hypertrophic cardiomyopathy in Taiwan may have a distinct morphology and clinical picture. METHODS:Information from 163 consecutive patients with hypertrophic cardiomyopathy a...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20057
更新日期:2007-04-01 00:00:00
abstract::Constrictive pericarditis is a fibrotic process involving both layers of the pericardium and is known to give rise to obstruction to blood flow in the right heart. We report a patient with constrictive pericarditis who had echocardiographic features of mitral stenosis caused by a fibrocalcific mass lesion involving th...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190615
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:We sought to determine whether lifestyle modifications are associated with high-density lipoprotein cholesterol (HDL-C) change in a cohort with long-term follow-up. HYPOTHESIS:Changes in alcohol consumption, smoking, or body mass index (BMI) are associated with within-individual changes in HDL-C. METHODS:W...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.21978
更新日期:2012-01-01 00:00:00
abstract::A case of systemic hypotension with volume depletion not responding to intravenous fluids was found to have features of cardiac tamponade on two-dimensional (2-D) echocardiography. Intracardiac pressures were normal on cardiac catheterization. An interesting observation was the presence of left ventricular (LV) collap...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960210318
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Familial hypercholesterolemia (FH) is a common autosomal dominant disease associated with premature coronary heart disease (CHD). Studies tend to show that patients with FH associated with an identified mutation (mutation+ FH) are at higher risk than patients without an identified mutation (mutation- FH). We...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22881
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Early reperfusion therapy has reduced the infarct size and mortality rate in patients with acute myocardial infarction (AMI). The occurrence of bundle-branch block in AMI is related to the amount of myocardial damage and the insult to the conduction system. HYPOTHESIS:To evaluate the clinical and angiograph...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960241204
更新日期:2001-12-01 00:00:00
abstract::The optimal approach to electrical cardioversion of atrial fibrillation includes appropriate patient selection, anticoagulation, careful selection and monitoring of antiarrhythmic therapy, and proper electrical cardioversion technique. The optimal technique requires the use of metal electrodes, with one electrode of a...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960170207
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Myocardial blush grade (MBG), corrected TIMI frame count (cTFC), and ST-segment reduction are indices of myocardial reperfusion. HYPOTHESIS:We evaluated their predictive value for left ventricular (LV) function recovery by gated single-photon emission computed tomography (SPECT) after acute myocardial infar...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960271205
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:Genetic influence on development of athlete's heart is uncertain. This study investigated whether angiotensin-converting enzyme (ACE) gene polymorphism influenced development of athlete's heart. METHODS:Forty-three participants in a 100-km ultramarathon were classified on the basis of ACE gen...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960230814
更新日期:2000-08-01 00:00:00
abstract::Coronary artery disease (CAD) is still the number-one killer in the world, and clinical trials indicate that it is preventable. Mortality and morbidity can be reduced by at least 30% to 40% by treating known risk factors. Genetic susceptibility is claimed to account for 50% of predisposition. The challenge of preventi...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22002
更新日期:2012-09-01 00:00:00
abstract::Cusp entrapment is a previously unreported mechanism of aortic insufficiency after balloon aortic valvuloplasty. In a patient who developed severe acute aortic insufficiency and expired after balloon aortic valvuloplasty, pathologic evaluation revealed a large, solitary, fractured, calcific nodule in the noncoronary c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120711
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease, insulin resistance (IR), and obesity frequently coexist with type 2 diabetes mellitus (DM), but it is uncertain whether these risk factors for vascular disease contribute to a change in atherosclerosis over time, independently of DM status. HYPOTHESIS:We hypothesized that t...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22529
更新日期:2016-06-01 00:00:00
abstract::The pseudoaneurysm is a rare cardiac pathology, in which the left ventricular free wall ruptures and the pericardium surrounds the rupture in combination with thrombus and inflammation and thus prevents the development of a hemopericardium. Left ventricular pseudoaneurysm may remain silent unless it gives rise to card...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20311
更新日期:2009-06-01 00:00:00
abstract::In addition to the role of the electrophysiological substrate, paroxysmal atrial fibrillation depends on the modulation of the atrial tissues by the autonomic nervous system. Experimentally, models of atrial fibrillation can be based on either adrenergic or vagal stimulations that provoke the arrhythmia by disturbing ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960130311
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Although women typically develop coronary artery disease several years after men, once they have symptomatic disease their thromboembolic complications are worse than in men. The mechanism mediating this gender difference in outcome after thromboembolic events is unknown. We previously studied platelet funct...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960191106
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Chronic stress is estimated to increase the risk of cardiovascular (CV) events two-fold. Although stress reduction has been linked to a reduction in CV events, little is known regarding its exact mechanism of benefit. HYPOTHESIS:Yoga and meditation will improve parameters of endothelial function. METHODS:W...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960290905
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Anticoagulation with heparin is recommended with intra-aortic balloon pump (IABP) to prevent thrombosis and embolization. However, anticoagulation increases the risk of bleeding, particularly in combination with glycoprotein (GP) IIb/IIIa antagonists. HYPOTHESIS:We investigated the safety of using GP IIb/II...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20297
更新日期:2009-02-01 00:00:00
abstract::Preoperative assessment of cardiac risk using thallium-201 scintigraphy and atrial pacing (n = 42) or dipyridamole stress testing (n = 35) was performed in 77 patients (mean age 65 +/- 7 years), who subsequently underwent elective nonvascular surgery. All patients were at low cardiac risk by clinical criteria; none co...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960130905
更新日期:1990-09-01 00:00:00
abstract::In 1350 patients with suspected acute myocardial infarction, serum potassium levels during the first 3 days in hospital was correlated to clinical history and clinical course. A higher incidence of hypokalemia was observed in women, in patients with hypertension, and in those on chronic diuretic treatment. Patients wi...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960111005
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:Exercise-induced dyspnea is a frequent feature in patients with hyperthyroidism. HYPOTHESIS:Data from clinical studies to elucidate the origin of this symptom are lacking. In the current study, we examined the hemodynamic and oxygenation responses to exercise and beta-adrenergic blockade in patients with hy...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270707
更新日期:2004-07-01 00:00:00
abstract::To enhance the bedside diagnosis of tricuspid regurgitation, the influence of manual pressure applied below the liver on lower left sternal border murmurs was determined in 23 patients. All 23 subjects had right ventriculograms and right atrial phonocardiograms. The sign was positive in 13 cases, including 3 who were ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960060605
更新日期:1983-06-01 00:00:00
abstract::The question of whether several attempts at transducer insertion increase the risk of performing transesophageal echocardiography (TEE) in patients with coronary artery disease (CAD) has not been addressed to date. In the course of performing TEE in 45 patients with CAD, two or more attempts to insert the transducer w...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960160807
更新日期:1993-08-01 00:00:00
abstract::Pregnant patients with mechanical prosthetic heart valves pose a great problem for medical management. The problem is even greater in a pregnant woman with mechanical valve thrombosis. This article describes a pregnant woman with prosthetic mitral valve thrombosis who had a successful fibrinolytic treatment. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20637
更新日期:2010-06-01 00:00:00
abstract::Three cases are presented where acute myocardial infarction occurred in young individuals after an episode of heavy alcohol intake. Subsequent coronary arteriograms demonstrated normal coronary arteries. Several mechanisms by which acute ethanol intoxication might precipitate myocardial infarction are discussed. To ou...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960050707
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:Myocardial perfusion imaging (MPI) provides incremental diagnostic and prognostic information, even in patients with high exercise tolerance. HYPOTHESIS:Myocardial perfusion imaging provides significant diagnostic value, specifically in women with high exercise tolerance. METHODS:Our study population consi...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960240611
更新日期:2001-06-01 00:00:00
abstract::The use of neuroleptanalgesia in acute myocardial infarction offers the possibility of reducing pain and emotional stress. The influence of such treatment on hemodynamic parameters (heart rate, cardiac output, stroke volume, peripheral resistance, systemic blood pressure, and pulmonary pressure) and on the plasma leve...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960040505
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND:Coronary artery disease (CAD) risk is not fully revealed by traditional risk factors. Identification of a simple, noninvasive tool that allows for detection of high-risk CAD patients and can be applied in large populations and clinical settings would prove valuable. HYPOTHESIS:We sought to test the hypothes...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20705
更新日期:2010-02-01 00:00:00
abstract::The pharmacologic management of the patient post myocardial infarction (MI) aims to achieve several goals. Chief among these is to prevent subsequent events, which include death, reinfarction, and rehospitalization. Secondary goals include preventing arrhythmias, minimizing left ventricular (LV) remodeling, and preven...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960281306
更新日期:2005-11-01 00:00:00