Combination therapy with nicardipine and beta-adrenergic blockade for angina pectoris.

Abstract:

:Nicardipine a second-generation dihidropyridine calcium antagonist, has been approved in oral formulation for use in the United States, and is under review for parenteral use. Nicardipine is the most vascular-selective agent of this class currently approved and should, on theoretical grounds, be ideal for combination therapy with beta-adrenergic blocking agents. Studies have shown that the combination of nicardipine and beta-blocking agents offers additional efficacy over monotherapy with either agent alone. The hemodynamic profile of combination therapy appears to be especially favorable in patients with diminished left ventricular function needing therapy with agents of both classes. Adverse effects are few and may be improved compared with other agents of the dihidropyridine class.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Lambert CR

doi

10.1002/clc.4960150403

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

231-4

issue

4

eissn

0160-9289

issn

1932-8737

journal_volume

15

pub_type

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