Appearance of electrocardiographic initial U-wave inversion dependent on pressure-induced early diastolic impairment in patients with hypertension.

Abstract:

BACKGROUND:ECG U-wave inversion can be classified as initial and terminal U inversion according to the phasic relationship to positive U-wave deflection. Initial U inversion is occasionally observed in hypertensive patients while terminal U inversion frequently appears during severe myocardial ischemia. HYPOTHESIS:The genesis of initial U inversion may be related to pressure-induced diastolic dysfunction. METHODS:In order to clarify the genesis of initial U-wave inversion we studied 11 consecutive hypertensive patients with both initial U inversion and impaired left ventricular early relaxation who were evaluated using Doppler echocardiography. RESULTS:The U inversion disappeared during acute pressure lowering by sublingual administration of nitroglycerin. The U inversion also disappeared and relaxation improved significantly after chronic blood pressure lowering. Initial U inversion reappeared during a cold pressor test. CONCLUSION:The appearance of initial U inversion was dependent on the pressure-induced impaired left ventricular early relaxation in hypertensive patients.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Miwa K

doi

10.1002/clc.20487

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

593-6

issue

10

eissn

0160-9289

issn

1932-8737

journal_volume

32

pub_type

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