Abstract:
BACKGROUND:ECG U-wave inversion can be classified as initial and terminal U inversion according to the phasic relationship to positive U-wave deflection. Initial U inversion is occasionally observed in hypertensive patients while terminal U inversion frequently appears during severe myocardial ischemia. HYPOTHESIS:The genesis of initial U inversion may be related to pressure-induced diastolic dysfunction. METHODS:In order to clarify the genesis of initial U-wave inversion we studied 11 consecutive hypertensive patients with both initial U inversion and impaired left ventricular early relaxation who were evaluated using Doppler echocardiography. RESULTS:The U inversion disappeared during acute pressure lowering by sublingual administration of nitroglycerin. The U inversion also disappeared and relaxation improved significantly after chronic blood pressure lowering. Initial U inversion reappeared during a cold pressor test. CONCLUSION:The appearance of initial U inversion was dependent on the pressure-induced impaired left ventricular early relaxation in hypertensive patients.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Miwa Kdoi
10.1002/clc.20487subject
Has Abstractpub_date
2009-10-01 00:00:00pages
593-6issue
10eissn
0160-9289issn
1932-8737journal_volume
32pub_type
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