Abstract:
:Therapy with an angiotensin-converting enzyme (ACE) inhibitor is established for reducing excessive blood pressure, reducing mortality in patients with congestive heart failure (CHF), preventing the development of CHF in patients with asymptomatic left ventricular (LV) dysfunction, and preventing death and CHF when initiated early after the onset of acute myocardial infarction (MI). Although these benefits have been attributed largely to hemodynamic mechanisms, recent preclinical and clinical evidence reveal ACE inhibition as potent in preventing ischemic events and in blocking an array of ischemic processes, including atherogenesis. A major contributor to this new evidence is the large, placebo-controlled Heart Outcomes Prevention Evaluation (HOPE) trial, which found that the ACE inhibitor ramipril ( 10 mg daily) prevented MI and other ischemic events in patients with a broad range of cardiovascular (CV) risks (including coronary artery disease, stroke, peripheral vascular disease, or diabetes plus one additional risk factor) but no LV dysfunction or history of heart failure at baseline. The data from the HOPE trial suggest a greatly expanded role for ramipril in the prevention and management of CV disease.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Pitt Bdoi
10.1002/clc.4960230704subject
Has Abstractpub_date
2000-07-01 00:00:00pages
IV9-14issue
7 Suppl 4eissn
0160-9289issn
1932-8737journal_volume
23pub_type
杂志文章,评审abstract::We describe two patients in whom spontaneous angina following acute myocardial infarction (postinfarction angina caused by coronary artery spasm) and worsening angina were successfully eliminated after clinical dosage of oral diltiazem, while marked sinus node suppression developed and temporary pacing was performed. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960071110
更新日期:1984-11-01 00:00:00
abstract::Serial echocardiographic findings in a patient with an Omniscience mitral prosthesis presenting progressive perivalvular pannus ingrowth are described. The first echocardiographic study was carried out one year after prosthesis implantation and showed decreased prosthetic opening velocity. As prosthetic thrombosis was...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960101021
更新日期:1987-10-01 00:00:00
abstract:INTRODUCTION:Health care demand is increasing due to greater longevity of patients with chronic comorbidities. This increasing demand is occurring in a setting of resource scarcity. To address these changes, high-value care initiatives, such as telemedicine, are valuable resource-preservation strategies. This study int...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22586
更新日期:2016-11-01 00:00:00
abstract::One of the most important roles for professional societies in medicine is assembling multiple stakeholders and experts to develop documents that can help guide and define policies and strategies for best medical care. Each year the Heart Rhythm Society (HRS) develops several consensus documents that address critical c...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22666
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Previously, perfusion defect in the left ventricle was detected by thallium-201 (201T1) single-photon emission computed tomography (SPECT) in aortic regurgitation (AR). The significance of 201T1 SPECT, however, has not been clarified. Limited information is available regarding the relationship between functi...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960281206
更新日期:2005-12-01 00:00:00
abstract::Cardiac anatomy and rhythm were evaluated in the fetuses of 18 pregnant women (between 20 and 42 weeks of gestation) referred because of abnormal fetal heart rate or rhythm. Utilizing a 3 MHz two-dimensional scan head with M-mode capability, M-mode recordings were obtained at paper speeds of 50 and 100 mm/s from 16 fe...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960080102
更新日期:1985-01-01 00:00:00
abstract::The prognosis for patients with non-Q-wave myocardial infarction (MI) remains controversial, although a number of studies have shown a less favorable outlook after hospital discharge for patients with non-Q-wave than for those with Q-wave infarction. Numerous management strategies are available to the clinician, many ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1989-07-01 00:00:00
abstract::Spontaneous coronary artery dissection (SCAD) is a rare cause of myocardial ischemia that could present as angina, acute myocardial infarction, or even sudden death. It occurs more commonly in women and it has been associated with autoimmune and collagen vascular diseases. The management and prognosis in these patient...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20540
更新日期:2010-07-01 00:00:00
abstract::To assess the immediate and long-term effects of exercise on factors regulating blood flow, we measured plasma viscosity (eta p) and plasma renin activity (PRA) in 17 trained runners and 16 sedentary healthy subjects before and 10 min after graded treadmill exercise. Resting eta p was lower in runners primarily becaus...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960040405
更新日期:1981-07-01 00:00:00
abstract::Pulmonary hypertension comprises a family of disorders occurring as a primary disease or as a complication of a large number of respiratory and cardiac diseases. Pulmonary hypertension is present when pulmonary artery pressure or mean pressure exceeds 30 mmHg or 20 mmHg, respectively. Underlying the hemodynamic change...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960200804
更新日期:1997-08-01 00:00:00
abstract::Many invasive and noninvasive methods have been used to study the cardiac atria; however, few allow quantitative measurement of atrial function. To determine the interaction between left ventricular (LV) contraction and left atrial (LA) filling, gated radionuclide angiography was conducted in 30 normal subjects (24 me...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170508
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The extracellular matrix tissue of the myocardium importantly contributes to left ventricular (LV) performance. Inherited connective tissue disorders related to the FBN1 gene could involve cardiac interstitium resulting in functional abnormalities. HYPOTHESIS:To disclose a primary involvement of myocardium,...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960250905
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Atherosclerosis is widely accepted as a chronic inflammatory disease. Research paid much attention to sensitive specific serum biomarkers for vulnerable plaques. The markers not only serve as diagnostic tools for the identification of patients with acute coronary syndrome (ACS), but also help us to identify ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20254
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Cardiac injury is common in COVID-19 patients and is associated with increased mortality. However, it remains unclear if reduced cardiac function is associated with cardiac injury, and additionally if mortality risk is increased among those with reduced cardiac function in COVID-19 patients. HYPOTHESIS:The ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23479
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Diabetic cardiomyopathy (DCMP) is a common complication of diabetes and is associated with increased mortality. It has been suggested that a poor R-wave progression in a resting electrocardiogram (ECG) could be a sign of cardiomyopathy. HYPOTHESIS:The aim of this study was primarily to analyze the relations...
journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.20810
更新日期:2010-09-01 00:00:00
abstract::In this editorial, I would like to share some thoughts about clinical studies, including value and limitations using as an example a recently published randomized clinical trial. Randomized and non-randomized clinical trials, epidemiologic studies, and registries guide our clinical practice. They are good but not perf...
journal_title:Clinical cardiology
pub_type: 社论
doi:10.1002/clc.20598
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Current guidelines for the use of implantable cardioverter-defibrillators (ICDs) are broad and significantly increase the cost of caring for patients with heart failure. In an effort to identify the specific subset of patients who benefit from this therapy, the predictive value of numerous echocardiographic ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20474
更新日期:2009-12-01 00:00:00
abstract::Mitral anulus calcification (MAC) and mitral valve prolapse (MVP) are frequently diagnosed conditions. We studied two patients with mild or moderate mitral regurgitation who demonstrated both MAC and MVP on angiography and echocardiography. M-mode echocardiography is probably the definitive test for confirming the pre...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960020309
更新日期:1979-06-01 00:00:00
abstract::A fulminant psychiatric disturbance, as the sole noncardiac manifestation of digitalis toxicity, emerged in a 85-year-old woman during treatment for congestive heart failure. Described more than a century ago as "digitalis delirium," the disorder is characterized by severe agitation, delusional thinking, assaultive be...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960180611
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Exercise-based rehabilitation is an important part of treatment patients following coronary artery bypass graft (CABG) surgery. HYPOTHESIS:To evaluate effect of very short/short-term exercise training on cardiopulmonary exercise testing (CPET) parameters. METHODS:We studied 54 consecutive patients with myo...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22656
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Preventive cardiology is currently not an American Board of Medical Specialties-recognized subspecialty. However, several programs offer non-accredited fellowships throughout the country. No source currently exists listing all available programs, and finding programs requires time-intensive search strategies...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.21959
更新日期:2012-05-01 00:00:00
abstract::The importance of a history of angina pectoris on long-term timolol treatment after myocardial infarction was studied with respect to mortality and reinfarction. The analyses were performed retrospectively using cohorts from the Norwegian timolol multicenter study. In patients without angina pectoris prior to the infa...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960080205
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Most information concerning hypertrophic cardiomyopathy has been derived from western countries and Japan. HYPOTHESIS:Patients with hypertrophic cardiomyopathy in Taiwan may have a distinct morphology and clinical picture. METHODS:Information from 163 consecutive patients with hypertrophic cardiomyopathy a...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20057
更新日期:2007-04-01 00:00:00
abstract::In 10 men with stable exertional angina, the changes in exercise capacity, hemodynamics, and left ventricular (LV) function were measured after 20 mg sublingual nifedipine (N) and again after adding 100 mg oral metoprolol (M). Nifedipine alone did not significantly improve exercise workloads (+18%) and duration (+21%)...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960080405
更新日期:1985-04-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a major independent risk factor for cardiovascular disease, and diabetic dyslipidemia is a major contributor to cardiovascular risk in these patients. Here we report the rationale and design of a phase 3, double-blind study specifically designed to evaluate the lipid-lowering efficac...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.23018
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:It has been suggested that episodes of silent myocardial ischemia (SMI) might influence the prognosis of patients with ischemic heart disease, as its consequences are similar to those of myocardial ischemia accompanied by pain. Ambulatory electrocardiogram (ECG) is generally employed in diagnosis as well as ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960190605
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Current National Cholesterol Education Program (NCEP) guidelines recognize low-density lipoprotein cholesterol (LDL-C) below 100 mg/dl as an optimal level. Evidence supporting this is scant. Both LDL-C and C reactive protein (CRP) are known correlates of atherosclerosis progression. HYPOTHESIS:We examined t...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960270105
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Although the outcome of patients with angiographically insignificantly narrowed coronary arteries (INCA) is not clearly defined, such lesions can progress or rupture, thus causing cardiovascular morbidity. Preventive therapy with aspirin and lipid-lowering drugs therefore seems warranted in these patients. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270605
更新日期:2004-06-01 00:00:00
abstract::Homozygous familial hypercholesterolemia (HFH) is a very rare autosomal dominant disease characterized by accelerated severe atherosclerosis. We examined 18 patients from 9 families with HFH. The age range was 6-30 years (mean = 16 years). Male to female ratio was equal. All patients had huge, multiple tuberous xantho...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120608
更新日期:1989-06-01 00:00:00
abstract::Intracoronary (i.c.) thrombus is a frequent finding in patients with unstable angina (UA). Accordingly, thrombolytic treatment could be beneficial, as resolution of thrombus might result in increased delivery of blood flow to the ischemic regions. To test this hypothesis, we studied 13 patients with active UA and ST-s...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960150206
更新日期:1992-02-01 00:00:00