Abstract:
BACKGROUND:Current National Cholesterol Education Program (NCEP) guidelines recognize low-density lipoprotein cholesterol (LDL-C) below 100 mg/dl as an optimal level. Evidence supporting this is scant. Both LDL-C and C reactive protein (CRP) are known correlates of atherosclerosis progression. HYPOTHESIS:We examined the effect of final LDL-C and CRP obtained with statin therapy on carotid intima-media thickness (CIMT), a valid surrogate for clinical benefit of lipid-lowering therapies. METHODS:In a randomized, single-center trial, 161 patients were assigned to statin therapy of different potencies (pravastatin 40 mg, n = 82; atorvastatin 80 mg, n = 79). The effects on CIMT were assessed in relationship to LDL-C and CRP levels obtained after 12 months of therapy. RESULTS:Changes in CIMT were directly related to the final LDL-C level obtained on statin therapy after 12 months (R = 0.219, p = 0.015). Carotid intima-media thickness regression was seen in 61% of the subjects in the lowest quartile of final LDL-C (< 70 mg/dl) versus 29% of the subjects with the highest quartile of final LDL-C (> or = 114 mg/dl, p = 0.008). No threshold value was seen, with more favorable effects on absolute change in CIMT with lower values of LDL-C (decrease in CIMT of 0.06 +/- 0.17 mm in the lowest quartile compared with an increase of 0.06 +/- 0.09 in the highest quartile of LDL-C, p = 0.008). On-treatment LDL and CRP concentrations both below the group median values were associated with the greatest likelihood of CIMT regression. CONCLUSIONS:Regression of carotid atherosclerosis is directly related to the absolute LDL-C level on statin therapy. The greatest regression was obtained with an LDL-C < 70 mg/dl, supporting marked LDL-C reduction to levels below current NCEP guidelines.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Kent SM,Coyle LC,Flaherty PJ,Markwood TT,Taylor AJdoi
10.1002/clc.4960270105subject
Has Abstractpub_date
2004-01-01 00:00:00pages
17-21issue
1eissn
0160-9289issn
1932-8737journal_volume
27pub_type
临床试验,杂志文章,随机对照试验abstract::The optimal approach to electrical cardioversion of atrial fibrillation includes appropriate patient selection, anticoagulation, careful selection and monitoring of antiarrhythmic therapy, and proper electrical cardioversion technique. The optimal technique requires the use of metal electrodes, with one electrode of a...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960170207
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abstract::Hypertrophic cardiomyopathy predisposes patients to atrial fibrillation and the development of systemic embolization. We describe a rare case of bilateral renal artery thrombosis which presented as acute renal failure requiring dialysis. The patient was successfully treated with a selective, continuous infusion of uro...
journal_title:Clinical cardiology
pub_type: 杂志文章
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journal_title:Clinical cardiology
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doi:10.1002/clc.4960190907
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journal_title:Clinical cardiology
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doi:10.1002/clc.4950260806
更新日期:2003-08-01 00:00:00
abstract::Six patients undergoing aortic valve replacement had rare or unusual causes of isolated, pure aortic regurgitation. Two patients had congenitally bicuspid aortic valves with a false commissure (raphe) displaced to the aortic wall ("tethered bicuspid aortic valve"), two had floppy aortic valves, one had a congenital qu...
journal_title:Clinical cardiology
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doi:10.1002/clc.4960130812
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更新日期:2014-01-01 00:00:00
abstract::Cocaine-related cardiovascular events escalated during the 1980s as cocaine became purer, cheaper, and easier to obtain. Cocaine abuse is a risk factor for myocardial ischemia and/or infarction, cardiac arrhythmias, pulmonary edema, ruptured aortic aneurysm, cerebral infarction, infective endocarditis, vascular thromb...
journal_title:Clinical cardiology
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doi:10.1002/clc.4960140626
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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更新日期:2001-04-01 00:00:00
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journal_title:Clinical cardiology
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doi:10.1002/clc.4960180313
更新日期:1995-03-01 00:00:00
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journal_title:Clinical cardiology
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doi:10.1002/clc.22015
更新日期:2012-08-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960201408
更新日期:1997-11-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Clinical cardiology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/clc.4960240611
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journal_title:Clinical cardiology
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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更新日期:1992-06-01 00:00:00