Abstract:
BACKGROUND:Diabetes mellitus (DM) is well established as a short-term prognostic indicator after myocardial infarction (MI), but little long-term data are available. HYPOTHESIS:The objective of the study was to assess the impact of DM and other patient characteristics at baseline on long-term mortality after acute MI. METHODS:Patients who were hospitalized with MI from December 1990 to November 1992 were recruited. Baseline data were recorded and patients were followed up through January 31, 2008, to assess their survival rates. Survival curves were generated by the Kaplan-Meier method. The main outcome measure was long-term survival (median 16.6 y). RESULTS:The study followed 337 patients (mean age 66.4 y, 61.1% men) for a median of 16.6 years. Using Cox regression analysis, survival was associated with history of MI (hazard ratio [HR]: 1.47, P = 0.016), DM at baseline (HR: 1.31, P = 0.038), and age (HR: 1.061 for each additional year, P < 0.001). By multivariable regression, cardiovascular mortality was also associated with previous MI (HR: 1.58, P = 0.017), DM at baseline (HR: 1.69, P = 0.001), and age (HR: 1.075 for each additional year, P < 0.001). There was no statistically significant difference between the HRs for history of MI and history of DM. CONCLUSIONS:Diabetic patients with MI have a higher long-term all-cause and cardiovascular mortality. Our data also show that in patients with MI, DM confers the same level of risk as a previous MI. This extends to patients with documented MI, our concept of diabetes being a coronary heart disease equivalent. Based on this and on data from the literature, we propose that it would be more accurate to consider DM as an MI equivalent rather than a coronary heart disease equivalent.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Gruppetta M,Calleja N,Fava Sdoi
10.1002/clc.20776subject
Has Abstractpub_date
2010-07-01 00:00:00pages
424-9issue
7eissn
0160-9289issn
1932-8737journal_volume
33pub_type
杂志文章abstract:BACKGROUND:Disruption of the atherosclerotic plaque is a common feature of both acute coronary syndromes and balloon dilatation of coronary artery stenoses. HYPOTHESIS:The study was undertaken to evaluate whether the known association of cholesterol levels and acute coronary syndromes also exists for the occurrence of...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4950260708
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pub_type: 杂志文章
doi:10.1002/clc.22224
更新日期:2014-02-01 00:00:00
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更新日期:1990-04-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.4960181107
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20998
更新日期:2012-01-01 00:00:00
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doi:10.1002/clc.22738
更新日期:2017-10-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960040505
更新日期:1981-09-01 00:00:00
abstract::This study analyzes the prevalence of coronary artery disease (CAD) among patients with rheumatic valvular heart disease (VHD) in Chile. Coronary angiography was performed in all patients referred to cardiac catheterization with VHD who were over age 50 years and who had angina or ECG signs of ischemia. A total of 100...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960060709
更新日期:1983-07-01 00:00:00
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doi:10.1002/clc.4960140626
更新日期:1991-06-01 00:00:00
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更新日期:2014-09-01 00:00:00
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更新日期:2017-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2010-02-01 00:00:00
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更新日期:1990-06-01 00:00:00