Release of adenosine and lactate from human hearts during atrial pacing in patients with ischemic heart disease.

Abstract:

:Thirty-eight patients treated by atrial pacing were divided into three groups (Group I, patients with neither coronary stenosis nor anginal pain during pacing; Group II, patients with no coronary stenosis but having anginal pain during pacing; Group III, patients with coronary stenosis). The concentrations of adenosine and lactate were measured in the coronary sinus blood and in the arterial blood before, during, and after atrial pacing. During atrial pacing, significant levels of adenosine were released from the heart of patients in Group III, whereas significant lactate release was observed in Groups II and III. In Group II, the concentration of adenosine in coronary sinus blood appeared to increase during pacing, but not significantly. There was no significant correlation between the release of adenosine and that of lactate. A significant release of adenosine due to atrial pacing may be observed only in patients with coronary artery disease.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Haneda T,Ichihara K,Abiko Y,Onodera S

doi

10.1002/clc.4960120203

subject

Has Abstract

pub_date

1989-02-01 00:00:00

pages

76-82

issue

2

eissn

0160-9289

issn

1932-8737

journal_volume

12

pub_type

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