Abstract:
BACKGROUND:Oxidized low-density lipoprotein (oxLDL) not only plays an important role in plaque formation, but also impairs the endothelium-dependent relaxation. Constrictive remodeling rather than intimal hyperplasia mainly contributes to restenosis after balloon angioplasty. Probucol (powerful antioxidant) reduced restenosis rate by improving constrictive remodeling. Thus, oxLDL may modulate coronary arterial remodeling. HYPOTHESIS:The study was designed for using intravascular ultrasound to test the hypothesis that arterial constrictive remodeling (CR) was associated with oxLDL in patients with coronary artery disease. METHODS:Intravascular ultrasound was performed in 36 patients with de novo atherosclerotic coronary. Remodeling was defined and evaluated as follows: remodeling index (RI) = lesion vessel area (VA)/(proximal reference VA + distal reference VA)/2. Constrictive remodeling (CR) was defined as remodeling index (RI) < 0.9. Neutral and expansive remodeling (NER) was defined as RI > or = 0.9. The level of plasma ox-LDL was measured by sandwich ELISA using the monoclonal antibody (DLH3)-recognized oxidatively modified lipoproteins and the antihuman apoprotein B monoclonal antibody. RESULTS:Neutral and expansive remodeling was found in 24 lesions, and CR in 12 lesions. Remodeling index was significantly lower in the CR group than in the NER group (0.8 +/- 0.1 vs. 1.0 +/- 0.1, p < 0.001). The level of oxLDL in the CR group was significantly higher than that in the NER group (24.0 +/- 12.1 vs. 16.4 +/- 6.2 U/ml, p < 0.05). The level of high-density lipoprotein-cholesterol (HDL-C) in the CR group was significantly lower than that in the NER group (40.5 +/- 4.8 vs. 46.2 +/- 10.6 mg/ml, p < 0.05). There was a statistically significant correlation between the value of HDL-C/ ox-LDL and the RI (r = -0.48, p < 0.005). CONCLUSIONS:Oxidized LDL and HDL-C were associated with arterial remodeling in de novo atherosclerotic lesions.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Yoneyama S,Arakawa K,Yonemura A,Isoda K,Nakamura H,Ohsuzu Fdoi
10.1002/clc.4960260107subject
Has Abstractpub_date
2003-01-01 00:00:00pages
31-5issue
1eissn
0160-9289issn
1932-8737journal_volume
26pub_type
杂志文章abstract:BACKGROUND:Elevated admission glucose level is a strong predictor of short-term adverse outcome in patients with acute coronary syndrome (ACS). However, the prognostic value of diabetic control (ie, hemoglobin A(1c) levels) in patients with ACS is still undefined. HYPOTHESIS:Hemoglobin A(1c) level may predict short-te...
journal_title:Clinical cardiology
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doi:10.1002/clc.20915
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journal_title:Clinical cardiology
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abstract:BACKGROUD:The association between underlying comorbidities and cardiac injury and the prognosis in coronavirus disease 2019 (COVID-19) patients was assessed in this study. HYPOTHESIS:The underlying comorbidities and cardiac injury may be associated with the prognosis in COVID-19 patients. METHODS:A systematic search ...
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abstract::Embolism of a fragment of a central venous catheter is a serious clinical complication, especially when the fragment cannot be made visible by radiological methods. We report a case where such a fragment could only be localized by transesophageal echocardiography (TEE). With combined use of x-rays and TEE, the cathete...
journal_title:Clinical cardiology
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doi:10.1002/clc.4960110614
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abstract:BACKGROUND:Females with Ullrich-Turner syndrome (UTS) have typical clinical features such as short stature, ovarian failure, visible dysmorphic stigmata, and abnormalities in different organs such as kidney or heart. HYPOTHESIS:The aim of the present study was to analyze the distribution, prevalence, and relative risk...
journal_title:Clinical cardiology
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journal_title:Clinical cardiology
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更新日期:2013-09-01 00:00:00
abstract::Cusp entrapment is a previously unreported mechanism of aortic insufficiency after balloon aortic valvuloplasty. In a patient who developed severe acute aortic insufficiency and expired after balloon aortic valvuloplasty, pathologic evaluation revealed a large, solitary, fractured, calcific nodule in the noncoronary c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960120711
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pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
abstract::To determine the accuracy of two-dimensional echocardiography (2-D echo) for assessment of exercise-induced wall motion abnormalities in patients with coronary artery disease, the results of stress echocardiography were compared with exercise cineventriculography. In 56 consecutive patients, biplane cineventriculograp...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960110808
更新日期:1988-08-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23327
更新日期:2020-04-01 00:00:00
abstract::Primary amyloidosis, systemic senile amyloidosis, isolated atrial amyloidosis, and transthyretin isoleucine 122 amyloidosis frequently involve the heart. Amyloid fibrils infiltrate the myocardium, impairing ventricular contraction and relaxation. The clinical manifestations of cardiac infiltration in these disorders a...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960210804
更新日期:1998-08-01 00:00:00
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doi:10.1002/clc.4960150514
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更新日期:2020-11-01 00:00:00
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pub_type: 社论,历史文章
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journal_title:Clinical cardiology
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
abstract::Cardiac anatomy and rhythm were evaluated in the fetuses of 18 pregnant women (between 20 and 42 weeks of gestation) referred because of abnormal fetal heart rate or rhythm. Utilizing a 3 MHz two-dimensional scan head with M-mode capability, M-mode recordings were obtained at paper speeds of 50 and 100 mm/s from 16 fe...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960080102
更新日期:1985-01-01 00:00:00
abstract::Sertraline is a selective serotonin reuptake inhibitor with established safety for the treatment of depression. Among the common adverse effects associated with sertraline are nausea, insomnia, diarrhea, somnolence, and dizziness. Cardiac arrest had not been reported in the literature, although tachycardia was frequen...
journal_title:Clinical cardiology
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
abstract::Endothelial dysfunction is increasingly recognized as an early event in the pathogenesis of cardiovascular disease. This observation is consistent with the growing appreciation of the role of endothelium in maintaining cardiovascular health. Endothelial dysfunction and coronary artery disease are both linked to hypert...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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journal_title:Clinical cardiology
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更新日期:1994-06-01 00:00:00
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journal_title:Clinical cardiology
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更新日期:1998-06-01 00:00:00