Abstract:
BACKGROUND:Atrial fibrillation (AF), a disease of the elderly, occasionally occurs at younger age. Pathophysiology of AF in younger patients is diverse, including channelopathies and cardiomyopathies. Data on the significance and complications of AF in young patients are scarce. HYPOTHESIS:Atrial fibrillation is the first manifestation of cardiovascular disease (CVD) in young patients. METHODS:From 11 888 patients in a university hospital database, patients age ≤35 years were identified. A composite of stroke/transient ischemic attack, thromboembolic events, major bleeding, and death was the primary endpoint. Stroke/transient ischemic attack, thromboembolic events, major bleeding, death, AF during follow-up, diagnosis of arrhythmia other than AF, and new diagnosis of any CVD were secondary endpoints. Endpoints were compared between patients with and without comorbidities. RESULTS:We identified 124 patients (29.1± 5 years). Of those, 84 were followed over 48.4 ± 39.8 months. Comorbidities were present in 40.5%. Incidence of the primary endpoint was not different between the groups. Arrhythmias other than AF were more common in patients without comorbidities (36% vs 14.7%; P = 0.032). A supraventricular tachycardia (SVT) was found in 57.1% of patients who underwent electrophysiological testing and was treated with catheter ablation. None of those patients had AF during follow-up. CONCLUSIONS:Atrial fibrillation occurs in young patients with and without structural heart disease. Young AF patients without comorbidities rarely develop CVD during the first years after diagnosis. Yet, an SVT is found in a high proportion of young AF patients; AF may be first manifestation of SVT. Therefore, young patients should undergo further evaluation for SVT.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Wutzler A,von Ulmenstein S,Attanasio P,Huemer M,Parwani AS,Völk K,Blaschke F,Boldt LH,Haverkamp Wdoi
10.1002/clc.22516subject
Has Abstractpub_date
2016-04-01 00:00:00pages
229-33issue
4eissn
0160-9289issn
1932-8737journal_volume
39pub_type
杂志文章abstract:BACKGROUND:Brugada syndrome (BrS) is associated with sudden cardiac death (SCD). Although implantable cardioverter-defibrillator (ICD) implantation is recommended, the long-term outcomes and follow-up data with regard to ICD complications have led to controversy. HYPOTHESIS:In the present study, we described the data ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 社论
doi:10.1002/clc.4960170405
更新日期:1994-04-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1002/clc.4960131310
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Late potentials (LP) on signal-averaged electrocardiography (SAECG), recorded 6 to 30 days after an acute myocardial infarction (AMI), identify patients at risk for late arrhythmic events. Angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce ventricular remodeling and cardiovascular morta...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:Clinical cardiology
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doi:10.1002/clc.20227
更新日期:2008-07-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960060406
更新日期:1983-04-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960210512
更新日期:1998-05-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.21013
更新日期:2012-04-01 00:00:00
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journal_title:Clinical cardiology
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更新日期:1989-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-12-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20703
更新日期:2010-06-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090608
更新日期:1986-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-11-01 00:00:00
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journal_title:Clinical cardiology
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doi:10.1002/clc.4960210209
更新日期:1998-02-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960070604
更新日期:1984-06-01 00:00:00
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doi:10.1002/clc.4960210814
更新日期:1998-08-01 00:00:00
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-09-01 00:00:00
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更新日期:1979-08-01 00:00:00
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更新日期:2008-09-01 00:00:00
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journal_title:Clinical cardiology
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doi:
更新日期:1980-04-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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