Rationale and design of the Drug-Eluting Stents vs Bare-Metal Stents in Saphenous Vein Graft Angioplasty (DIVA) Trial.

Abstract:

:VA Cooperative Studies Program #571 (DIVA) was designed to evaluate the efficacy of drug-eluting stents (DES) for reducing aortocoronary saphenous vein bypass graft (SVG) failure when compared with bare-metal stents (BMS) in participants undergoing stenting of de novo SVG lesions. Participants undergoing clinically indicated stenting of de novo SVG lesions were randomized in a 1:1 ratio to DES or BMS. Randomization was stratified by presence/absence of diabetes mellitus and the number of target SVG lesions (1 vs ≥2) within each participating site. At sites that did not routinely administer 12-months of dual antiplatelet therapy after SVG stenting participants without acute coronary syndromes received 1 month of open-label clopidogrel, followed by 11 months of clopidogrel for those assigned to DES and 11 months of placebo for those assigned to BMS. The primary endpoint was the 12-month incidence of target-vessel failure (defined as the composite of cardiac death, target-vessel myocardial infarction, or target-vessel revascularization). Secondary endpoints included the incidence of other clinical endpoints and the incremental cost-effectiveness of DES relative to BMS. Due to lower-than-anticipated target-vessel failure rates, target enrollment was increased from 519 to 762. The study had randomized 599 participants when recruitment ended in December 2015. The DIVA trial will provide clarity on the appropriate stent type for de novo SVG lesions.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Brilakis ES,Banerjee S,Edson R,Shunk K,Goldman S,Holmes DR Jr,Bhatt DL,Rao SV,Smith MW,Sather M,Colling C,Kar B,Nielsen L,Conner T,Wagner T,Rangan BV,Ventura B,Lu Y,Holodniy M,Shih MC

doi

10.1002/clc.22763

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

946-954

issue

11

eissn

0160-9289

issn

1932-8737

journal_volume

40

pub_type

杂志文章,多中心研究,随机对照试验
  • Magnetic resonance imaging (MRI) in different stages of myocardial infarction using the contrast agent gadolinium-DTPA.

    abstract::We investigated 26 patients admitted to our catheterization laboratory with a diagnosis of acute myocardial infarction. In each case acute revascularization was unsuccessful, but the diagnosis was confirmed by angiography. In 11 patients with an uncomplicated course of acute myocardial infarction magnetic resonance im...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960091102

    authors: Eichstaedt HW,Felix R,Dougherty FC,Langer M,Rutsch W,Schmutzler H

    更新日期:1986-11-01 00:00:00

  • Conversion of infarction-associated atrial fibrillation by restoration of atrial perfusion.

    abstract::We report a patient who presented with new onset atrial fibrillation in the setting of inferior ST-segment elevation myocardial infarction (STEMI). Cardiac catheterization revealed proximal occlusion of the left circumflex artery. Balloon angioplasty and stenting restored flow to a large left atrial branch, with promp...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20573

    authors: Blanton RM,Nappi A,Kimmelstiel CD

    更新日期:2010-12-01 00:00:00

  • Association of coronary calcification with obstructive disease in coronary arteries in Indian patients.

    abstract::A total of 1150 consecutive patients (1052 males and 98 females; age 51.2 +/- 10.1 years) with suspected coronary artery disease (Group I) were subjected to fluoroscopy for detection of coronary artery calcification (CAC) and coronary angiography. Another group (Group II) of 120 patients (95 males and 25 females; age ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960110705

    authors: Wasir HS,Dev V,Kaul U,Rajani M,Mukherjee S,Sharma S,Bhatia ML

    更新日期:1988-07-01 00:00:00

  • Adenosine triphosphate and adenosine: perspectives in the acute management of paroxysmal supraventricular tachycardia.

    abstract::Adenosine triphosphate (ATP) and adenosine exert strong and transient depressant effects on the sinoatrial and atrioventricular (AV) nodes of the human heart. The AV nodal effects of these drugs explain their high efficacy in either terminating AV re-entrant supraventricular tachycardia or in slowing ventricular rate ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960080903

    authors: Belhassen B,Pelleg A

    更新日期:1985-09-01 00:00:00

  • Independent effects of body fat and inflammatory markers on ventricular geometry, midwall function, and atrial remodeling.

    abstract:BACKGROUND:The effect of body fat distribution on left ventricular (LV) mass and geometry has been recently recognized. However, data regarding circulating inflammatory markers in relation to regional visceral fat deposits, which are metabolically active tissues that can impact cardiac structural remodeling, remain spa...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22242

    authors: Lai YH,Liu CC,Kuo JY,Hung TC,Wu YJ,Yeh HI,Bulwer BE,Hung CL

    更新日期:2014-03-01 00:00:00

  • Heart transplantation and left ventricular assist device therapy: two comparable options in end-stage heart failure?

    abstract::Heart transplantation is the only curative therapy for chronic heart failure, and it plays an important role in the treatment of chronic heart failure with a survival rate of approximately 50% of all patients after 10 years. This has to be kept in mind when alternative therapies enter into our daily routine in treatin...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.22124

    authors: Garbade J,Barten MJ,Bittner HB,Mohr FW

    更新日期:2013-07-01 00:00:00

  • Cocaine: the newest risk factor for cardiovascular disease.

    abstract::Cocaine-related cardiovascular events escalated during the 1980s as cocaine became purer, cheaper, and easier to obtain. Cocaine abuse is a risk factor for myocardial ischemia and/or infarction, cardiac arrhythmias, pulmonary edema, ruptured aortic aneurysm, cerebral infarction, infective endocarditis, vascular thromb...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960140626

    authors: Cregler LL

    更新日期:1991-06-01 00:00:00

  • Quantification of left-side intracardiac pressures and gradients using mitral and aortic regurgitant velocities by simultaneous left and right catheterization and continuous-wave Doppler echocardiography.

    abstract::Noninvasive determination of left-side intracardiac pressures is of clinical importance in many cardiac diseases. To test the reliability and accuracy of left-side intracardiac pressure measurements by continuous-wave Doppler echocardiography, using left-side valvular regurgitations, 47 patients with mitral regurgitat...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960161206

    authors: Ge ZM,Zhang Y,Fan DS,Zhang M,Fan JX,Zhao YX

    更新日期:1993-12-01 00:00:00

  • Impact of prior permanent pacemaker on long-term clinical outcomes of patients undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:The impact of permanent pacemaker (PPM) on long-term clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) has not been studied. HYPOTHESIS:PPM may increase heart failure (HF) burden on patients undergoing PCI. METHODS:We recruited consecutive patients undergoing PCI and carried...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22645

    authors: Li YJ,Zhang WW,Yang XX,Li N,Qiu XB,Qu XK,Fang WY,Yang YQ,Li RG

    更新日期:2017-04-01 00:00:00

  • Valve-in-valve transcatheter aortic valve replacement to treat multijet paravalvular regurgitation: A case series and review.

    abstract::Treatment advances for severe symptomatic aortic stenosis including transcatheter and open surgical valve replacement have improved patient survival, length of stay, and speed to recovery. However, paravalvular regurgitation (PVR) is occasionally seen and when moderate or greater in severity is associated with an at l...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.23504

    authors: Randall MH,Lewandowski TJ,Choi C,Beaver TM

    更新日期:2021-01-01 00:00:00

  • Importance of alpha 1-sympathetic activity for diurnal change in ischemic threshold in patients with stable angina.

    abstract:BACKGROUND:Although ischemic threshold reportedly is lower in the early morning than in the afternoon, the mechanisms that account for the diurnal change in minimal coronary vascular resistance in the potentially ischemic area are unknown. HYPOTHESIS:We hypothesized that calcium-channel blockers and alpha 1 blockers m...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960210512

    authors: Fujita M,Tanaka T,Nakae I,Tamaki S,Kihara Y,Nohara R,Sasayama S

    更新日期:1998-05-01 00:00:00

  • Occurrence of hypokalemia in suspected acute myocardial infarction and its relation to clinical history and clinical course.

    abstract::In 1350 patients with suspected acute myocardial infarction, serum potassium levels during the first 3 days in hospital was correlated to clinical history and clinical course. A higher incidence of hypokalemia was observed in women, in patients with hypertension, and in those on chronic diuretic treatment. Patients wi...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960111005

    authors: Herlitz J,Hjalmarson A,Bengtson A

    更新日期:1988-10-01 00:00:00

  • Implantable cardioverter-defibrillator in Brugada syndrome: Long-term follow-up.

    abstract:BACKGROUND:Brugada syndrome (BrS) is associated with sudden cardiac death (SCD). Although implantable cardioverter-defibrillator (ICD) implantation is recommended, the long-term outcomes and follow-up data with regard to ICD complications have led to controversy. HYPOTHESIS:In the present study, we described the data ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.23247

    authors: El-Battrawy I,Roterberg G,Liebe V,Ansari U,Lang S,Zhou X,Borggrefe M,Akin I

    更新日期:2019-10-01 00:00:00

  • Postinfarction left ventricular pseudoaneurysm.

    abstract::Left ventricular wall rupture after myocardial infarction is a mechanical complication that may result in a pseudoaneurysm. Between January 1994 and October 1996, false or pseudoaneurysms were detected in 6 (0.0026%) of 2,600 consecutive patients (4 women, 2 men; mean age 59.4 years) undergoing cardiac catheterization...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960201021

    authors: Csapo K,Voith L,Szuk T,Edes I,Kereiakes DJ

    更新日期:1997-10-01 00:00:00

  • Stress damage to nonischemic divisions of the heart in experimental infarction and its prevention.

    abstract::Recently, it has been shown that nonischemic parts of the heart in myocardial infarction were separated from ischemic damaged ones by a sharp border zone. In this connection, the disturbance of contractile function of the myocardium of nonischemic parts is suggested to result from the infarction-concomitant emotional-...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960060403

    authors: Meerson FZ

    更新日期:1983-04-01 00:00:00

  • Cannabinoids and atherosclerotic coronary heart disease.

    abstract::Marijuana is the most abused recreational drug in the United States. Cannabinoids, the active ingredients of marijuana, affect multiple organ systems in the human body. The pharmacologic effects of marijuana, based on stimulation of cannabinoid receptors CB1 and CB2, which are widely distributed in the cardiovascular ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.21962

    authors: Singla S,Sachdeva R,Mehta JL

    更新日期:2012-06-01 00:00:00

  • Peripartum cardiomyopathy: A systematic review of the literature.

    abstract::Peripartum cardiomyopathy (PPCM) is a rare cause of heart failure. It is defined as cardiomyopathy that develops in the last month of pregnancy or within 5 months of the postpartum period without an identifiable cause. We conducted a systematic review of literature of prospective studies with a focus on echocardiograp...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.22932

    authors: Asad ZUA,Maiwand M,Farah F,Dasari TW

    更新日期:2018-05-01 00:00:00

  • Association between anxiety and clinical outcomes in Chinese patients with myocardial infarction in the absence of obstructive coronary artery disease.

    abstract:BACKGROUND:Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) accounts for approximately 5% - 6% of acute myocardial infarction (AMI) patients. Anxiety symptoms are common in patients with coronary artery disease (CAD), and are associated with a poor prognosis. However, the association...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.23386

    authors: He CJ,Zhu CY,Han B,Hu HZ,Wang SJ,Zhai CL,Hu HL

    更新日期:2020-07-01 00:00:00

  • Twenty-four-hour ambulatory oxygen desaturation and electrocardiographic recording in obstructive sleep apnea syndrome.

    abstract:BACKGROUND:Although nocturnal pulseoximetry is routinely performed in obstructive sleep apnea syndrome (OSAS), pulseoximetry over a 24-h period has not been studied. HYPOTHESIS:The purpose of the study was to determine whether simultaneous 24-h oxygen desaturation and electrocardiographic (ECG) recording might be used...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960210710

    authors: Noda A,Ito R,Okada T,Yasuma F,Nakashima N,Yokota M

    更新日期:1998-07-01 00:00:00

  • The association of QRS duration with atrial fibrillation in a heart failure with preserved ejection fraction population: a pilot study.

    abstract:BACKGROUND:Heart failure is a significant cause of morbidity and mortality, yet patient risk stratification may be difficult. Prevention or treatment of atrial fibrillation (AF) may be an important strategy in these patients that could positively affect their outcome. It has been demonstrated that in patients with syst...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22736

    authors: Gigliotti JN,Sidhu MS,Robert AM,Zipursky JS,Brown JR,Costa SP,Palac RT,Steckman DA,Malenka DJ,Kono AT,Greenberg ML

    更新日期:2017-10-01 00:00:00

  • An evaluation of two-dimensional echocardiography in the diagnosis of hypertrophic cardiomyopathy.

    abstract::Various anatomical and functional features of hypertrophic cardiomyopathy are analyzed in view of the data provided by two-dimensional echocardiography. Measurement of septal thickness is crucial, and is best done by a combination of M-Mode and 2-D echo. Two types of systolic anterior movement of the mitral valve (SAM...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960071203

    authors: Ballester M,Rees S,Rickards AF,McDonald L

    更新日期:1984-12-01 00:00:00

  • Effect of acute exercise on the raised plasma fibrinogen, soluble P-selectin and von Willebrand factor levels in chronic atrial fibrillation.

    abstract:BACKGROUND:There is increasing evidence that chronic atrial fibrillation (AF) is associated with a prothrombotic or hypercoagulable state. HYPOTHESIS:This study was undertaken to determine whether short-term exercise in patients with chronic AF would shift the overall hemostatic balance toward a more prothrombotic sta...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960240512

    authors: Li-Saw-Hee FL,Blann AD,Edmunds E,Gibbs CR,Lip GY

    更新日期:2001-05-01 00:00:00

  • Cardiac rehabilitation in older adults: New options.

    abstract::Cardiac rehabilitation (CR) is an important component in the continuum of care for patients with cardiovascular diseases, including the older population. Benefits of CR which include mortality benefit, decreased hospitalizations, increased functional capacity all extend to an older population. In Medicare beneficiarie...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.23296

    authors: Kumar KR,Pina IL

    更新日期:2020-02-01 00:00:00

  • Multimarker approach to risk stratification among patients with advanced chronic heart failure.

    abstract:BACKGROUND:Cardiac troponin I (cTnI), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hsCRP) each predict adverse cardiac events in chronic heart failure (CHF). However, little is known about the utility of these novel biomarkers of CHF in combination. HYPOTHESIS:: We hyp...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20171

    authors: Yin WH,Chen JW,Feng AN,Lin SJ,Young S

    更新日期:2007-08-01 00:00:00

  • Strategies for managing the patient with acute non-Q-wave myocardial infarction.

    abstract::The prognosis for patients with non-Q-wave myocardial infarction (MI) remains controversial, although a number of studies have shown a less favorable outlook after hospital discharge for patients with non-Q-wave than for those with Q-wave infarction. Numerous management strategies are available to the clinician, many ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Boden WE

    更新日期:1989-07-01 00:00:00

  • Relationship between cardiovascular disease knowledge and race/ethnicity, education, and weight status.

    abstract:BACKGROUND:Inadequate cardiovascular disease (CVD) knowledge has been cited to account for the imperfect decline in CVD among women over the last 2 decades. HYPOTHESIS:Due to concerns that at-risk women might not know the leading cause of death or symptoms of a heart attack, our goal was to assess the relationship bet...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20992

    authors: Giardina EG,Mull L,Sciacca RR,Akabas S,Flink LE,Moise N,Paul TK,Dumas NE,Bier ML,Mattina D

    更新日期:2012-01-01 00:00:00

  • Lack of association between electronic health record systems and improvement in use of evidence-based heart failure therapies in outpatient cardiology practices.

    abstract:BACKGROUND:Electronic health record systems (EHR) are expected to facilitate higher quality patient care; however, studies evaluating EHR effectiveness in improving care have yielded mixed results. HYPOTHESIS:Implementation of a performance improvement system in outpatient practices with EHR may better demonstrate the...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.21971

    authors: Walsh MN,Albert NM,Curtis AB,Gheorghiade M,Heywood JT,Liu Y,Mehra MR,O'Connor CM,Reynolds D,Yancy CW,Fonarow GC

    更新日期:2012-03-01 00:00:00

  • Losartan and end-organ protection--lessons from the RENAAL study.

    abstract:BACKGROUND:The Reduction in ENdpoints with the Angiotensin Antagonist Losartan (RENAAL) study reported that losartan delayed the progression of renal disease in patients with type 2 diabetes and nephropathy. Diabetic or renally impaired patients are at high cardiovascular risk, a risk potentially increased in patients ...

    journal_title:Clinical cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1002/clc.4960280307

    authors: Kowey PR,Dickson TZ,Zhang Z,Shahinfar S,Brenner BM,RENAAL Investigators.

    更新日期:2005-03-01 00:00:00

  • Acute ischemic exacerbation of rheumatic mitral regurgitation.

    abstract::This report describes a patient who developed acute severe exacerbation of mild rheumatic mitral regurgitation caused by ischemia in the territory of a small, non-dominant circumflex coronary artery without myocardial infarction. ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960151215

    authors: Simpson IA,Sneddon J,Millane T,Pepper JR,Ward DE

    更新日期:1992-12-01 00:00:00

  • Total serum transforming growth factor-β1 is elevated in the entire spectrum of genetic aortic syndromes.

    abstract:BACKGROUND:Total serum transforming growth factor-beta 1 (tsTGF-β1) is increased in patients with Marfan syndrome (MFS), but it has not been assessed in thoracic aortic aneurysm and dissection (TAAD), Loeys-Dietz syndrome (LDS), and bicuspid aortic valve disease (BAVD). HYPOTHESIS:tsTGF-β1 is increased in genetic aort...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22320

    authors: Hillebrand M,Millot N,Sheikhzadeh S,Rybczynski M,Gerth S,Kölbel T,Keyser B,Kutsche K,Robinson PN,Berger J,Mir TS,Zeller T,Blankenberg S,von Kodolitsch Y,Goldmann B

    更新日期:2014-11-01 00:00:00