Abstract:
:VA Cooperative Studies Program #571 (DIVA) was designed to evaluate the efficacy of drug-eluting stents (DES) for reducing aortocoronary saphenous vein bypass graft (SVG) failure when compared with bare-metal stents (BMS) in participants undergoing stenting of de novo SVG lesions. Participants undergoing clinically indicated stenting of de novo SVG lesions were randomized in a 1:1 ratio to DES or BMS. Randomization was stratified by presence/absence of diabetes mellitus and the number of target SVG lesions (1 vs ≥2) within each participating site. At sites that did not routinely administer 12-months of dual antiplatelet therapy after SVG stenting participants without acute coronary syndromes received 1 month of open-label clopidogrel, followed by 11 months of clopidogrel for those assigned to DES and 11 months of placebo for those assigned to BMS. The primary endpoint was the 12-month incidence of target-vessel failure (defined as the composite of cardiac death, target-vessel myocardial infarction, or target-vessel revascularization). Secondary endpoints included the incidence of other clinical endpoints and the incremental cost-effectiveness of DES relative to BMS. Due to lower-than-anticipated target-vessel failure rates, target enrollment was increased from 519 to 762. The study had randomized 599 participants when recruitment ended in December 2015. The DIVA trial will provide clarity on the appropriate stent type for de novo SVG lesions.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Brilakis ES,Banerjee S,Edson R,Shunk K,Goldman S,Holmes DR Jr,Bhatt DL,Rao SV,Smith MW,Sather M,Colling C,Kar B,Nielsen L,Conner T,Wagner T,Rangan BV,Ventura B,Lu Y,Holodniy M,Shih MCdoi
10.1002/clc.22763subject
Has Abstractpub_date
2017-11-01 00:00:00pages
946-954issue
11eissn
0160-9289issn
1932-8737journal_volume
40pub_type
杂志文章,多中心研究,随机对照试验abstract::We investigated 26 patients admitted to our catheterization laboratory with a diagnosis of acute myocardial infarction. In each case acute revascularization was unsuccessful, but the diagnosis was confirmed by angiography. In 11 patients with an uncomplicated course of acute myocardial infarction magnetic resonance im...
journal_title:Clinical cardiology
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journal_title:Clinical cardiology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1992-12-01 00:00:00
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更新日期:2014-11-01 00:00:00