Abstract:
:At present, there is an exponential use of new interventional techniques whose proper role and value have not yet been defined. The intracoronary stent is just one example. There is no doubt that stents can be implanted with a high technical success rate associated with highly predictable immediate angiographic results and that they appear to be superior to all other interventional techniques. However, the intrinsic thrombogenicity of all devices currently available for clinical use warrants a vigorous anticoagulation, exposing the patient either to the risk of (sub)acute stent thrombosis or to the risk of hemorrhage and vascular complications. It remains to be determined whether stent implantation will reduce the incidence of restenosis and whether this results in an improved long-term event and symptom-free survival. Experimental studies indicate that the thrombogenic nature of stents may be controlled by coating the struts with endothelial cells or polymers. With respect to restenosis, it is evident that as long as mechanical injury is applied to the vessel wall, the vessel wall will respond with neointimal thickening. The intracoronary stent has the potential to control this tissue response by serving as a carrier for local antiproliferative drug delivery or eventually for genetic manipulation. The intensive research which is now going on in combination with experimental animal data, human postmortem pathologic observations, and angiographic studies is yielding clear insights and future directions to address these issues.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
de Jaegere PP,de Feyter PJ,van der Giessen WJ,Serruys PWdoi
10.1002/clc.4960160503subject
Has Abstractpub_date
1993-05-01 00:00:00pages
369-78issue
5eissn
0160-9289issn
1932-8737journal_volume
16pub_type
杂志文章,评审abstract:BACKGROUND:Ventricular arrhythmias are the most common consequences of structural and functional heart diseases, but cases with no evident pathology are also observed. A parameter indicating asymptomatic circulatory failure could support decisions related to possible treatment of ventricular arrhythmias. HYPOTHESIS:Th...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20611
更新日期:2009-12-01 00:00:00
abstract::Stress echocardiography is a widely applied technique for the evaluation of individuals with known or suspected coronary artery disease. The technique combines echocardiographic imaging with exercise testing or pharmacologic stress. Advances in digital image acquisition and harmonic imaging have substantially improved...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960230404
更新日期:2000-04-01 00:00:00
abstract::In order to test the comparative sensitivities of first-pass radionuclide and digital subtraction ventriculography in detecting wall motion abnormalities during exercise, 29 patients referred for coronary angiography were submitted to both types of stress ventriculograms. Resting and exercise ventriculograms by both t...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960090906
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:Brugada syndrome (BrS) is associated with sudden cardiac death (SCD). Although implantable cardioverter-defibrillator (ICD) implantation is recommended, the long-term outcomes and follow-up data with regard to ICD complications have led to controversy. HYPOTHESIS:In the present study, we described the data ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.23247
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) accounts for approximately 5% - 6% of acute myocardial infarction (AMI) patients. Anxiety symptoms are common in patients with coronary artery disease (CAD), and are associated with a poor prognosis. However, the association...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23386
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Inadequate cardiovascular disease (CVD) knowledge has been cited to account for the imperfect decline in CVD among women over the last 2 decades. HYPOTHESIS:Due to concerns that at-risk women might not know the leading cause of death or symptoms of a heart attack, our goal was to assess the relationship bet...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20992
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Patients with phenotypic severe hypercholesterolemia (SH), low-density lipoprotein-cholesterol (LDL-c) ≥ 190 mg/dl, atherosclerotic cardiovascular disease (ASCVD) or adults 40-75 years with diabetes with risk factors or 10-year ASCVD risk ≥20% benefit from maximally tolerated statin therapy. Rural patients h...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23521
更新日期:2020-12-23 00:00:00
abstract::The impact of transient myocardial ischemia on left ventricular function was examined by digital subtraction left ventricular angiography. Contrast medium was injected into the right pulmonary artery before, at 60 seconds of balloon inflation, and 10 minutes after balloon deflation. A total of 69 patients completed th...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960140808
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Compared with medical therapy, percutaneous coronary intervention (PCI) does not reduce mortality or myocardial infarction in patients with stable angina. Therefore, PCI should be guided by refractory anginal symptoms and not just lesion characteristics. HYPOTHESIS:We hypothesized that angiographic lesion c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22510
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Although sudden death (SD) is a rare complication after atrioventricular junction (AVJ) ablation and permanent pacemaker implantation, the risk factors leading to this SD remain unknown. The purpose of this study was to investigate SD and its risk factors after ablate-and-pace strategy for rate control in at...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22600
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The impact of permanent pacemaker (PPM) on long-term clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) has not been studied. HYPOTHESIS:PPM may increase heart failure (HF) burden on patients undergoing PCI. METHODS:We recruited consecutive patients undergoing PCI and carried...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22645
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Takotsubo cardiomyopathy (TCM) is characterized by systolic ballooning of the left ventricular apex. It is triggered by emotional or physical stress, but the exact mechanism through which stress leads to TCM is not known. HYPOTHESIS:Coronary microvessel apoptosis is the missing link between stress and TCM. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20777
更新日期:2010-06-01 00:00:00
abstract::Preoperative assessment of cardiac risk using thallium-201 scintigraphy and atrial pacing (n = 42) or dipyridamole stress testing (n = 35) was performed in 77 patients (mean age 65 +/- 7 years), who subsequently underwent elective nonvascular surgery. All patients were at low cardiac risk by clinical criteria; none co...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960130905
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:The objective of this study was to estimate the prevalence of prehypertension and hypertension in the rural adults of Liaoning province of China. METHODS:The study was conducted in 2004-2006, using a multistage cluster sampling method to select a representative sample. A total of 45925 adults, 35 years or o...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20073
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The effect of body fat distribution on left ventricular (LV) mass and geometry has been recently recognized. However, data regarding circulating inflammatory markers in relation to regional visceral fat deposits, which are metabolically active tissues that can impact cardiac structural remodeling, remain spa...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22242
更新日期:2014-03-01 00:00:00
abstract::In the past, many have avoided nuts because of their high fat content. The Dietary Approaches to Stop Hypertension (DASH) diet, however, recommends regular consumption of this food along with seeds and dried beans (4-5 servings per week) as part of a diet to control hypertension. Nuts are nutrient-dense and most of th...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960221504
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Intravenous inotropic intervention in congestive heart failure is generally associated with a poor prognosis and is largely used as a "bridge" to mechanical support or heart transplantation. HYPOTHESIS:We hypothesized that the inotropic support afforded by dobutamine may serve as a bridge to the introductio...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960240311
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Congenital coronary-pulmonary fistulas (CPFs) are commonly unilateral, but bilateral and multilateral fistulas may occur. In multilateral CPFs, the value of a multidetector computed tomography (MDCT) imaging technique as an adjuvant to coronary angiography (CAG) is eminent. The purpose of this study was to d...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22297
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Data are being accumulated on the presence of inflammatory response in patients with acute coronary syndromes. HYPOTHESIS:The study was undertaken to confirm that the adhesive state of the peripheral blood leukocytes can provide information on an inflammatory process in patients with unstable angina pectori...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960201208
更新日期:1997-12-01 00:00:00
abstract::Transient left ventricular (LV) apical ballooning and normal epicardial coronary arteries are the hallmarks of Takotsubo cardiomyopathy. The syndrome is often triggered by emotional or physiologic stress, and its pathogenesis is poorly understood. Current proposals focus on elevated cathecolamines in association with ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20065
更新日期:2007-07-01 00:00:00
abstract::The use of contrast echocardiography (CE) in cardiovascular medicine has grown significantly over the last 15 years. Depending on the site of injection, contrast enhancement of the right- or left-sided cardiac chambers or myocardium now can be achieved. Contrast echocardiography can improve the evaluation of patients ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960201308
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:In patients with stable angina pectoris, eccentric stenoses have a greater potential for dynamic changes of caliber in response to vasoactive stimuli than concentric lesions. It is not known whether in patients with coronary artery spasm the degree of coronary vasoconstriction differs in eccen...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960210907
更新日期:1998-09-01 00:00:00
abstract::A 56-year-old male with atrial fibrillation developed rapid ventricular response up to 200 beats/min or more in the postoperative stage of emergency aortocoronary bypass surgery. Resuscitation for cardiac arrest triggered this rapid ventricular rate. The idea that retrograde conduction into atrioventricular node may p...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100412
更新日期:1987-04-01 00:00:00
abstract::Peripartum cardiomyopathy (PPCM) is a rare cause of heart failure. It is defined as cardiomyopathy that develops in the last month of pregnancy or within 5 months of the postpartum period without an identifiable cause. We conducted a systematic review of literature of prospective studies with a focus on echocardiograp...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22932
更新日期:2018-05-01 00:00:00
abstract::Treatment advances for severe symptomatic aortic stenosis including transcatheter and open surgical valve replacement have improved patient survival, length of stay, and speed to recovery. However, paravalvular regurgitation (PVR) is occasionally seen and when moderate or greater in severity is associated with an at l...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.23504
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The reproducibility of left ventricular (LV) mass measurement by two-dimensional (2-D) echocardiography is inadequate for individual assessments. HYPOTHESIS:This study was undertaken to evaluate the potential of LV mass determination with a new three-dimensional (3-D) echocardiographic method compared with ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960201111
更新日期:1997-11-01 00:00:00
abstract::The majority of older patients who develop heart failure (HF), particularly older women, have a preserved left ventricular ejection fraction (HFpEF). Patients with HFpEF have severe symptoms of exercise intolerance, poor quality-of-life, frequent hospitalizations, and increased mortality. The prevalence of HFpEF is in...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.23321
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Successful smoking cessation in stroke and coronary artery disease (CAD) patients is important, as smoking contributes to significant morbidity and mortality. The American Heart Association developed Get With The Guidelines (GWTG) to improve compliance with national guideline recommendations for cardiovascul...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.22023
更新日期:2012-01-01 00:00:00
abstract::Physicians previously perceived heart disease to be a man's disease; yet, since 1984, more women have died of ischemic heart disease. Because women who develop obstructive coronary heart disease and heart failure tend to do so 10 years later than men, cardiology clinical trials that use arbitrary age cutoffs or exclus...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22907
更新日期:2018-02-01 00:00:00
abstract::Coronary artery disease (CAD) is still the number-one killer in the world, and clinical trials indicate that it is preventable. Mortality and morbidity can be reduced by at least 30% to 40% by treating known risk factors. Genetic susceptibility is claimed to account for 50% of predisposition. The challenge of preventi...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.22002
更新日期:2012-09-01 00:00:00