Taking cardiology clinical trials to the next level: A call to action.

abstract：BACKGROUND:Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) accounts for approximately 5% - 6% of acute myocardial infarction (AMI) patients. Anxiety symptoms are common in patients with coronary artery disease (CAD), and are associated with a poor prognosis. However, the association...

journal_title：Clinical cardiology

authors： He CJ,Zhu CY,Han B,Hu HZ,Wang SJ,Zhai CL,Hu HL

更新日期：2020-07-01 00:00:00

abstract：:Despite the proven benefits of using antiplatelet therapy in patients undergoing percutaneous coronary intervention (PCI), a number of key questions remain to be answered. In recent years, clopidogrel dosing strategies among such patients have evolved considerably, with newer approaches involving loading doses prior t...

journal_title：Clinical cardiology

authors： Braunwald E,Angiolillo D,Bates E,Berger PB,Bhatt D,Cannon CP,Furman MI,Gurbel P,Michelson AD,Peterson E,Wiviott S

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The role of electrocardiogram (ECG) is unclear for the longitudinal follow-up of patients who undergo corrective surgery for isolated severe tricuspid regurgitation (TR). HYPOTHESIS:This study sought to investigate the usefulness of changes in QRS duration of ECG after TR surgery in predicting right ventric...

journal_title：Clinical cardiology

authors： Seo MK,Park EA,Kim HK,Lee W,Kim YJ,Kim KH,Kim KB,Sohn DW,Ahn H,Park JH

更新日期：2012-11-01 00:00:00

abstract：:Catheter ablation has become an accepted technique for creating complete heart block in patients with drug refractory supraventricular tachycardias. However, it remains experimental for other indications, such as ablation of accessory pathway or ventricular tachycardia. The use of high energy defibrillator discharges ...

journal_title：Clinical cardiology

authors： Cunningham D

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Anticoagulation with heparin is recommended with intra-aortic balloon pump (IABP) to prevent thrombosis and embolization. However, anticoagulation increases the risk of bleeding, particularly in combination with glycoprotein (GP) IIb/IIIa antagonists. HYPOTHESIS:We investigated the safety of using GP IIb/II...

journal_title：Clinical cardiology

authors： Laish-Farkash A,Hod H,Matetzky S,Guetta V

更新日期：2009-02-01 00:00:00

abstract：:In order to assess the diagnostic value of dipyridamole (D) testing, we studied the responses of 34 patients with chest pain and 10 normal subjects. Blood pressure and 12-lead ECG were recorded during and after intravenous infusion of 0.6 mg/kg dipyridamole for 10 minutes. Coronary arteriography and maximal or symptom...

journal_title：Clinical cardiology

authors： DeAmbroggi L,Barbieri P,DeBiase AM,Repetto S,Radice M

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Early reperfusion therapy has reduced the infarct size and mortality rate in patients with acute myocardial infarction (AMI). The occurrence of bundle-branch block in AMI is related to the amount of myocardial damage and the insult to the conduction system. HYPOTHESIS:To evaluate the clinical and angiograph...

journal_title：Clinical cardiology

authors： Sugiura T,Yamasaki F,Hatada K,Nakamura S,Iwasaka T

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Cibenzoline, a class Ia antiarrhythmic drug, can be used to relieve left ventricular (LV) outflow obstruction in hypertrophic obstructive cardiomyopathy (HOCM). However, the mechanism of this agent in HOCM has been controversial. HYPOTHESIS:This study was designed to investigate the effect of cibenzoline on...

journal_title：Clinical cardiology

authors： Kondo I,Mizushige K,Nozaki S,Hirao K,Iwado Y,Ohmori K,Matsuo H

更新日期：2000-09-01 00:00:00

abstract：:Patients with atrial fibrillation (AF) have an increased stroke risk compared with those in sinus rhythm, although the absolute risk for individual patients is modulated by the presence of various additional risk factors. Patient selection for oral anticoagulation for stroke prevention is based on risks of stroke and ...

journal_title：Clinical cardiology

authors： Verheugt FW

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Troponin I (TnI) is increasingly employed as a highly specific marker of acute myocardial ischemia. The value of this marker after cardiac surgery is unclear. HYPOTHESIS:The purpose of this study was to measure serum TnI levels prospectively at 1, 6, and 72 h after elective cardiac operations. In addition, ...

journal_title：Clinical cardiology

authors： Horvath KA,Parker MA,Frederiksen JW,Palmer AS,Fullerton DA

更新日期：2000-10-01 00:00:00

abstract：:Heart transplantation is the only curative therapy for chronic heart failure, and it plays an important role in the treatment of chronic heart failure with a survival rate of approximately 50% of all patients after 10 years. This has to be kept in mind when alternative therapies enter into our daily routine in treatin...

journal_title：Clinical cardiology

authors： Garbade J,Barten MJ,Bittner HB,Mohr FW

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Brugada syndrome (BrS) is associated with sudden cardiac death (SCD). Although implantable cardioverter-defibrillator (ICD) implantation is recommended, the long-term outcomes and follow-up data with regard to ICD complications have led to controversy. HYPOTHESIS:In the present study, we described the data ...

journal_title：Clinical cardiology

authors： El-Battrawy I,Roterberg G,Liebe V,Ansari U,Lang S,Zhou X,Borggrefe M,Akin I

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Intravenous inotropic intervention in congestive heart failure is generally associated with a poor prognosis and is largely used as a "bridge" to mechanical support or heart transplantation. HYPOTHESIS:We hypothesized that the inotropic support afforded by dobutamine may serve as a bridge to the introductio...

journal_title：Clinical cardiology

authors： Levine TB,Levine AB,Elliott WG,Narins B,Stomel RJ

更新日期：2001-03-01 00:00:00

abstract：:Congestive heart failure (CHF) is a common manifestation of hypertension, coronary artery disease, and dilated cardiomyopathy. The Framingham study showed that the incidence of CHF increases twofold with each decade of age. The presence of CHF increases the age-adjusted death rate 5.5-fold for women and 8-fold for men...

journal_title：Clinical cardiology

authors： Greene HL

更新日期：1992-09-01 00:00:00

abstract：:Recent clinical investigations have provided new insights into physiologic alterations taking place as heart failure progresses. As a result, new end points may be more relevant to monitor in patients, rather than the classical assessment of severity based on subjective evaluation of functional capacity. Structural ch...

journal_title：Clinical cardiology

authors： Cohn JN

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Insulin resistance is clearly associated with coronary artery disease (CAD) in diabetics. Insulin resistance may also be present in normoglycemic individuals, and some of these patients can be diagnosed as having metabolic syndrome (MS) according to various definitions. However, the relationship between hype...

journal_title：Clinical cardiology

authors： Deveci E,Yesil M,Akinci B,Yesil S,Postaci N,Arikan E,Koseoglu M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Exercise-based rehabilitation is an important part of treatment patients following coronary artery bypass graft (CABG) surgery. HYPOTHESIS:To evaluate effect of very short/short-term exercise training on cardiopulmonary exercise testing (CPET) parameters. METHODS:We studied 54 consecutive patients with myo...

journal_title：Clinical cardiology

authors： Spiroski D,Andjić M,Stojanović OI,Lazović M,Dikić AD,Ostojić M,Beleslin B,Kostić S,Zdravković M,Lović D

更新日期：2017-05-01 00:00:00

abstract：:Five multicenter, randomized, double-blind, placebo-controlled studies were conducted in France to compare the efficacy and safety of once-daily simvastatin treatment (10-40 mg/day) with conventional therapy with gemfibrozil 900 mg/day, ciprofibrate 100 mg/day, bezafibrate 400 mg/day, and fenofibrate 300 or 400 mg/day...

journal_title：Clinical cardiology

authors： Bruckert E,De Gennes JL,Malbecq W,Baigts F

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) readmission rates have become an increasingly important quality metric since the advent of the Hospital Readmissions Reduction Program. Despite many well-intentioned efforts to reduce readmissions, clinicians continue to struggle with the problem of high HF readmission rates. HYPOTHESIS:H...

journal_title：Clinical cardiology

authors： Sommerfeld A,Althouse AD,Prince J,Atwood CW,Mulukutla SR,Hickey GW

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the influence of atrial fibrillation (AF) on the immediate and long-term outcome of patients undergoing balloon mitral valvotomy (BMV). HYPOTHESIS:Patients with atrial fibrillation fair poorly after balloon mitral valvotomy. METHODS:There were a total of 818 consecu...

journal_title：Clinical cardiology

authors： Nair KK,Pillai HS,Thajudeen A,Krishnamoorthy KM,Sivasubramonian S,Namboodiri N,Sasidharan B,Ganapathy S,Varaparambil A,Titus T,Tharakan J

更新日期：2012-12-01 00:00:00

abstract：:The short-term hemodynamic and possible arrhythmogenic effects of intravenous salbutamol at a dose of 30 or 60 micrograms/min were evaluated in 14 patients with severe chronic left ventricular dysfunction using equilibrium radionuclide angiocardiography and electrocardiographic monitoring. Salbutamol infusions at a do...

journal_title：Clinical cardiology

authors： Rotstein Z,Battler A,Rath S,Perek J,Eldar M

更新日期：1990-07-01 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) derived from a melanoma cell line was first used in patients with acute myocardial infarction in the early 1980s. Recombinant DNA technology then allowed production of large amounts of t-PA. The TIMI-I trial used a two-chain recombinant (rt-PA) product. A predominantly single-c...

journal_title：Clinical cardiology

authors： DeWood MA,Kurnik PB,Jolly MK,Jain AC,Khaja F,Gorfinkel HJ,Morris DL,Satler L,LittleJohn J

更新日期：1993-04-01 00:00:00

abstract：:Several investigators have documented the successful use of oral sustained-release theophylline in treating symptomatic bradycardia and sick sinus syndrome. This paper reports a case of chronotropic incompetence in which specific exercise indices, including the chronotropic response index, were used to measure the the...

journal_title：Clinical cardiology

authors： Dixon WC 4th,Bauch TD

更新日期：2000-10-01 00:00:00

abstract：:The coronary sinus (CS) is a small tubular structure just above the posterior left atrioventricular junction. The CS can be imaged in several different echocardiographic views. Using zoom M-mode recordings of the CS in apical two-chamber view, CS caliber can be sharply imaged and easily measured during different phase...

journal_title：Clinical cardiology

authors： D'Cruz IA,Shala MB,Johns C

更新日期：2000-03-01 00:00:00

abstract：:Recently two types of atypical T-wave evolution were recognized as electrocardiographic (ECG) markers of regional postinfarction pericarditis. The sensitivity and specificity of these changes for this condition were 100 and 77%, respectively. The major purpose of this investigation is to show how these ECG changes can...

journal_title：Clinical cardiology

authors： Oliva PB,Hammill SC

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Marfan's syndrome is an inherited disorder of connective tissue associated with characteristic abnormalities of the skeletal, ocular, and cardiovascular systems. Marked clinical variability and age dependency of all manifestations of Marfan's syndrome may render the unequivocal diagnosis difficult in mildly ...

journal_title：Clinical cardiology

authors： Mercuro G,Carpiniello B,Ruscazio M,Zoncu S,Montisci R,Rudas N,Cherchi A

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Although women typically develop coronary artery disease several years after men, once they have symptomatic disease their thromboembolic complications are worse than in men. The mechanism mediating this gender difference in outcome after thromboembolic events is unknown. We previously studied platelet funct...

journal_title：Clinical cardiology

authors： Goldschmidt-Clermont PJ,Schulman SP,Bray PF,Chandra NC,Grigoryev D,Dise KR,Sagar M,Fox RJ,Coleman LD,Richardson C,Dorsey FC,du Mee C,Kitt MM,Ouyang P,Baughman KL,Gerstenblith G

更新日期：1996-11-01 00:00:00

abstract：:Thrombolytic therapy for prosthetic heart valve thrombosis has recently been receiving increased attention and is now frequently used an alternative to high-risk surgery. A case is presented describing a novel thrombolytic therapy regimen with emphasis on the role of transesophageal echocardiography in diagnosis and m...

journal_title：Clinical cardiology

authors： Puleo JA,Fontanet HL,Schocken DD

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Identifying patients with advanced left atrial (LA) remodeling before catheter ablation (CA) of atrial fibrillation (AF) is crucial. HYPOTHESIS:This study aimed to identify echocardiographic parameters associated with changes in anatomy and conduction properties of the left atrium (LA). METHODS:We examined...

journal_title：Clinical cardiology

authors： Nedios S,Löbe S,Knopp H,Seewöster T,Heijman J,Crijns HJGM,Arya A,Bollmann A,Hindricks G,Dinov B

更新日期：2021-01-01 00:00:00

abstract：:Atrial septal aneurysm in the otherwise normal heart is a very rare and usually asymptomatic condition. A midsystolic click was described as the only clinical manifestation so far. A low-pitched early-to-midsystolic acoustic phenomenon in a 39-year-old woman corresponding with maximal leftward motion of the aneurysmat...

journal_title：Clinical cardiology

authors： Kautzner J,Bĕlohlávek M,Holm FV,Munclinger MJ

更新日期：1992-07-01 00:00:00