Abstract:
:Lithium has been used for the treatment of bipolar disorder for more than 6 decades. Reports of cardiac side effects resulting in both benign electrocardiographic (ECG) changes and near fatal arrhythmias have been reported in the literature. A systematic literature search was conducted on 2 electronic databases-PubMed and Medline-for the time period between January 1970 and March 2016 using the key word "lithium," along with "electrocardiography" or "ECG." All articles and their references were then screened by title for relevance by 2 authors and a librarian. A total of 406 articles were found on literature search, of which 56 met the screening criteria. T wave inversion was the most frequently reported ECG finding. Other findings include sinus node dysfunction, sinoatrial blocks, PR prolongation, QT prolongation/dispersion, and ventricular tachyarrhythmias. Some cases have shown lithium-treated patients experiencing serious cardiac outcomes, such as ST elevation myocardial infarction, heart blocks, and the Brugada pattern. Electrical changes from lithium were found to be dependent on both duration of treatment and the serum lithium level. Although there are no standardized ECG guidelines, frequent monitoring of patients on lithium therapy can ensure the medication's safe use.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Mehta N,Vannozzi Rdoi
10.1002/clc.22822subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1363-1367issue
12eissn
0160-9289issn
1932-8737journal_volume
40pub_type
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journal_title:Clinical cardiology
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journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章,多中心研究
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更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/clc.4960280109
更新日期:2005-01-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220212
更新日期:1999-02-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.21978
更新日期:2012-01-01 00:00:00
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pub_type: 评论,社论
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pub_type: 杂志文章,meta分析,评审
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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