Abstract:
:The combination of cilostazol, aspirin, and clopidogrel (triple therapy) after percutaneous coronary intervention has been considered as an alternative therapy. We performed a meta-analysis based on 8 randomized controlled trials with a total of 3332 patients to compare the effectiveness and safety of this triple therapy with traditional dual therapy (aspirin and clopidogrel). Our findings suggested that the triple therapy is more effective than dual therapy in preventing restenosis (odds ratio [OR]: 0.52, 95% confidence interval [CI]: 0.40-0.66, P < 0.00001), maintaining minimal lumen diameter (OR: 0.15, 95% CI: 0.10-0.20, P < 0.00001), and avoiding target-vessel revascularization (OR: 0.62, 95% CI: 0.47-0.82, P = 0.001). There is also no significant difference in major adverse cardiac and cerebrovascular events between the 2 therapies, except the smaller occurrence rate of target-lesion revascularization in the triple-therapy group (OR: 0.42, 95% CI: 0.26-0.69, P = 0.0005). However, the triple therapy is associated with a higher level of adverse drug events, including rash (OR: 2.45, 95% CI: 1.41-4.23, P = 0.001), gastrointestinal disorders (OR: 2.59, 95% CI: 1.26-5.30, P = 0.009), and drug discontinuation (OR: 3.80, 95% CI: 1.59-9.10, P = 0.003), but it has no difference in bleeding compared with the dual therapy (OR: 1.05, 95% CI: 0.71-1.55, P = 0.80).
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Wang P,Zhou S,Zhou R,Liu G,Tang P,He J,Ma C,He Y,Yang Jdoi
10.1002/clc.22001subject
Has Abstractpub_date
2012-10-01 00:00:00pages
598-604issue
10eissn
0160-9289issn
1932-8737journal_volume
35pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:We sought to determine whether lifestyle modifications are associated with high-density lipoprotein cholesterol (HDL-C) change in a cohort with long-term follow-up. HYPOTHESIS:Changes in alcohol consumption, smoking, or body mass index (BMI) are associated with within-individual changes in HDL-C. METHODS:W...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.21978
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is well established as a short-term prognostic indicator after myocardial infarction (MI), but little long-term data are available. HYPOTHESIS:The objective of the study was to assess the impact of DM and other patient characteristics at baseline on long-term mortality after acute MI....
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20776
更新日期:2010-07-01 00:00:00
abstract::Stress echocardiography is a widely applied technique for the evaluation of individuals with known or suspected coronary artery disease. The technique combines echocardiographic imaging with exercise testing or pharmacologic stress. Advances in digital image acquisition and harmonic imaging have substantially improved...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960230404
更新日期:2000-04-01 00:00:00
abstract::Evidence is now accumulating which strongly suggests that prognosis of patients with painless myocardial ischemia determined either by ambulatory ECG monitoring or exercise testing may be no different than the prognosis of patients who have overt clinical manifestations of myocardial ischemia associated with transient...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960111202
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Prior studies suggest that the incidence of ventricular arrhythmias is high in patients with Fabry cardiomyopathy. This study evaluated the incidence of significant arrhythmias in a series of patients with Fabry cardiomyopathy. HYPOTHESIS:Arrhythmias are important causes of morbidity and mortality in Fabry ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22047
更新日期:2012-12-01 00:00:00
abstract::This report describes the case of a patient who developed postinfarction left ventricular free wall rupture and cardiac tamponade. He was managed conservatively, made a successful recovery, and is alive and asymptomatic 10 months after the index episode. Only 17 cases in which the patients survived subacute rupture of...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220317
更新日期:1999-03-01 00:00:00
abstract::K-strophanthin or digoxin were added to diuretics (all cases) and vasodilators (most cases) for treating advanced congestive heart failure in 22 patients with dilated cardiomyopathy and sinus rhythm. K-strophanthin (0.125 mg intravenously) or digoxin (0.25 mg orally) were administered daily in two 3-month periods, dur...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960171005
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:Previous research has failed to document temporal changes in epinephrine levels in patients with neurally mediated syncope associated with exercise. The purpose of this study was to investigate the role of circulatory catecholamines in exercise-induced neurally mediated syncope, specifically f...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Therapy for acute myocardial infarction has advanced dramatically since the early 1980s with the use of early intravenous fibrinolytic therapy. Combining low-dose fibrinolysis and platelet lysis appears to provide an additional increase in infarct-related artery (IRA) patency, but the large-scale mortality reduction t...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960221605
更新日期:1999-08-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22302
更新日期:2014-08-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.21971
更新日期:2012-03-01 00:00:00
abstract::Catheter ablation has become an accepted technique for creating complete heart block in patients with drug refractory supraventricular tachycardias. However, it remains experimental for other indications, such as ablation of accessory pathway or ventricular tachycardia. The use of high energy defibrillator discharges ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960140712
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:The impact of permanent pacemaker (PPM) on long-term clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) has not been studied. HYPOTHESIS:PPM may increase heart failure (HF) burden on patients undergoing PCI. METHODS:We recruited consecutive patients undergoing PCI and carried...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22645
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Separately, electrophysiologic study (EPS) and placement of a transvenous implantable cardioverter-defibrillator (ICD) can be performed safely in the majority of patients. The safety and potential cost savings of same-setting procedures have not been evaluated. HYPOTHESIS:Electrophysiologic study and placem...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960240905
更新日期:2001-09-01 00:00:00
abstract::The effects of monotherapy with atenolol or diltiazem-SR on blood pressure, 24-h blood pressure (BP) load, and exercise capacity were tested in patients with mild to moderate (stages I and II) essential hypertension. After 3-week single-blind placebo therapy, patients with sitting diastolic blood pressure (SDBP) of 94...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/clc.4960171209
更新日期:1994-12-01 00:00:00
abstract::Endothelial dysfunction is increasingly recognized as an early event in the pathogenesis of cardiovascular disease. This observation is consistent with the growing appreciation of the role of endothelium in maintaining cardiovascular health. Endothelial dysfunction and coronary artery disease are both linked to hypert...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960211103
更新日期:1998-11-01 00:00:00
abstract::The effect of intravenous bepridil, a new calcium antagonist with class I and III properties, was tested in 21 patients with sustained ventricular tachyarrhythmias refractory to a mean of five antiarrhythmic agents as assessed by programmed right ventricular stimulation. At control electrophysiologic study without ant...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960131209
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Recently, several treadmill scores have been proposed as means for improving the diagnostic accuracy of the exercise treadmill test (ETT). Questions remain regarding the diagnostic accuracy of treadmill scores when applied to a different patient population than that from which they were derived; furthermore,...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960250307
更新日期:2002-03-01 00:00:00
abstract::Rising costs have reached a point at which physicians must assume a major role in dealing with the cost of medicine. Little information is available regarding actual practice at the community hospital level. In order to develop some insight on this issue, a survey of cardiovascular specialists was conducted regarding ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960140104
更新日期:1991-01-01 00:00:00
abstract::Pulmonary hypertension comprises a family of disorders occurring as a primary disease or as a complication of a large number of respiratory and cardiac diseases. Pulmonary hypertension is present when pulmonary artery pressure or mean pressure exceeds 30 mmHg or 20 mmHg, respectively. Underlying the hemodynamic change...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960200804
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) accounts for approximately 5% - 6% of acute myocardial infarction (AMI) patients. Anxiety symptoms are common in patients with coronary artery disease (CAD), and are associated with a poor prognosis. However, the association...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23386
更新日期:2020-07-01 00:00:00
abstract::In 2009, much was written about computed tomography (CT) angiography of the coronary circulation and little about catheter-based coronary angiography, despite its continued use since 1958 in patients with all types of cardiac disease or potential disease. ...
journal_title:Clinical cardiology
pub_type: 评论,社论
doi:10.1002/clc.20741
更新日期:2010-01-01 00:00:00
abstract::A rare case of an adult patient with Shone's syndrome is presented in whom Lev's disease seems to be the major pathology underlying the development of complete A-V block. ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100116
更新日期:1987-01-01 00:00:00
abstract::The treatment of hypertension continues to be challenging due to the lack of understanding regarding underlying modulators of blood pressure as well as co-existing conditions such as atherosclerosis and diabetes. This has led to uncertainty regarding treatment strategy and intensity. The INternational VErapamil SR/tra...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960241705
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Emerging biomarkers for acute myocardial infarction (AMI) may enhance conventional risk-prediction algorithms if they are informative and associated with risk independently of established predictors. In this study, we constructed a cohort for testing emerging biomarkers for AMI in managed-care populations us...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.22146
更新日期:2013-08-01 00:00:00
abstract::Lipoprotein (a) [Lp(a)] concentrations were determined in 365 patients undergoing coronary angiography for stable angina (n = 159), unstable angina (n = 99), recent myocardial infarction (n = 45), and nonischemic heart disease (cardiomyopathy or valvular disease, n = 62, non-IHD). Mean +/- SD and median Lp(a) concentr...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960180909
更新日期:1995-09-01 00:00:00
abstract::Thrombolytic therapy for prosthetic heart valve thrombosis has recently been receiving increased attention and is now frequently used an alternative to high-risk surgery. A case is presented describing a novel thrombolytic therapy regimen with emphasis on the role of transesophageal echocardiography in diagnosis and m...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
doi:10.1002/clc.4960181117
更新日期:1995-11-01 00:00:00
abstract::This report describes the development of a quality assurance-oriented integrated software system designed for an anesthesiology-based intraoperative transesophageal echocardiography service. Entry data include patient and operation demographics, two-dimensional echocardiographic, saline-contrast, and color flow/pulsed...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960161012
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease, insulin resistance (IR), and obesity frequently coexist with type 2 diabetes mellitus (DM), but it is uncertain whether these risk factors for vascular disease contribute to a change in atherosclerosis over time, independently of DM status. HYPOTHESIS:We hypothesized that t...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22529
更新日期:2016-06-01 00:00:00
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journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.20885
更新日期:2011-06-01 00:00:00