Abstract:
BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) participates in the recruitment of mononuclear cells to the vessel wall. HYPOTHESIS:The aim of the study was to evaluate the potential association between serum concentration of MCP-1 and risk of future cardiovascular events in patients with chronic coronary heart disease. METHODS:A nested case control design was used. Baseline serum samples were taken from patients with coronary heart disease who were enrolled in a secondary prevention study. The MCP-1 levels were measured in those patients who had recurrent cardiovascular events during follow-up (n = 233) and compared with levels in age- and gender-matched controls. RESULTS:There were no differences in serum MCP-1 levels between cases and controls. The relative odds of a recurrent cardiovascular event for each 1 standard deviation difference in MCP-1 serum concentration (160 pg/ml) was 1.19 (95% confidence interval, 0.95-1.45). No increase in the relative odds for recurrent cardiovascular events was observed per increasing tertiles of MCP-1 concentrations. CONCLUSION:Elevated MCP-1 levels are not associated with long-term risk of cardiovascular events in patients with stable coronary disease.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Haim M,Tanne D,Boyko V,Reshef T,Goldbourt U,Battler A,Mekori YA,Behar Sdoi
10.1002/clc.4960280109subject
Has Abstractpub_date
2005-01-01 00:00:00pages
31-5issue
1eissn
0160-9289issn
1932-8737journal_volume
28pub_type
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