Abstract:
:Recent investigations have indicated that chronic heart failure can be reversed with agents that inhibit the reninangiotensin-aldosterone or sympathetic nervous system, such as angiontensin-converting enzyme (ACE) inhibitors and beta blockers. A meta-analysis of clinical trials of ACE inhibition in chronic heart failure reported reductions in mortality ranging from 13 to 33%, but as ACE inhibitors do not block chronic noradrenergic stimulation of the heart, mortality remains unacceptably high. Beta blockers have been shown to increase left ventricular ejection fraction, reduce end-systolic and end-diastolic cardiac dimensions, improve quality of life, and reduce mortality. All-cause mortality in the US Carvedilol trial was reduced 65%, and in MERIT-HF there was a 49% reduction in mortality from heart failure among patients receiving metoprolol CR/XL. MERIT-HF was ended early because of evidence of survival benefit. Although certain effects of beta blockers may be considered class effects, it is not yet clear whether there are differences between beta 1-selective antagonists and nonselective agents. The benefits conferred across differences in disease severity, race, and age should be answered as large ongoing and planned clinical trials of beta blockers are completed.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Eichhorn EJsubject
Has Abstractpub_date
1999-10-01 00:00:00pages
V21-9eissn
0160-9289issn
1932-8737journal_volume
22 Suppl 5pub_type
杂志文章,评审abstract::A patient with reversible coronary artery spasm superimposed on fixed atherosclerotic coronary disease was treated with percutaneous transluminal angioplasty. The procedure successfully dilated the atherosclerotic lesion. However, 20 minutes later, the patient developed coronary artery spasm at the angioplasty site. S...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960061206
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:ST-segment depression during exercise testing is frequently observed in the absence of restenosis after percutaneous transluminal coronary angioplasty (PTCA). HYPOTHESIS:With the goal of improving the prediction of restenosis after PTCA, we evaluated the usefulness of ST-segment depression plus QT dispersio...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220608
更新日期:1999-06-01 00:00:00
abstract::Three cases are presented where acute myocardial infarction occurred in young individuals after an episode of heavy alcohol intake. Subsequent coronary arteriograms demonstrated normal coronary arteries. Several mechanisms by which acute ethanol intoxication might precipitate myocardial infarction are discussed. To ou...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960050707
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:Cardiac troponin T elevation after coronary intervention has been demonstrated to be associated with the prognosis of coronary artery disease (CAD). However, there were few studies about comprehensive risk factors analysis of troponin T elevation after elective drug-eluting stent (DES) implantation. HYPOTHE...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20973
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Late potentials (LP) on signal-averaged electrocardiography (SAECG), recorded 6 to 30 days after an acute myocardial infarction (AMI), identify patients at risk for late arrhythmic events. Angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce ventricular remodeling and cardiovascular morta...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960230206
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:When used in appropriately selected heart failure (HF) patients, cardiac resynchronization therapy (CRT) reduces mortality and hospitalization. It is not understood whether CRT implantation during hospitalization for HF is associated with similar benefits. HYPOTHESIS:Timing of CRT implantation relative to h...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究
doi:10.1002/clc.23135
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Marfan's syndrome is an inherited disorder of connective tissue associated with characteristic abnormalities of the skeletal, ocular, and cardiovascular systems. Marked clinical variability and age dependency of all manifestations of Marfan's syndrome may render the unequivocal diagnosis difficult in mildly ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960200311
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Atherosclerosis is widely accepted as a chronic inflammatory disease. Research paid much attention to sensitive specific serum biomarkers for vulnerable plaques. The markers not only serve as diagnostic tools for the identification of patients with acute coronary syndrome (ACS), but also help us to identify ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20254
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:For patients with ST elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI), rapid restoration of coronary blood flow is the primary therapeutic goal. Because of the acute nature of this clinical presentation, bleeding risks may not be adequately evaluated, limiting the us...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20295
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Plaque rupture with subsequent transient thrombotic coronary occlusion by a fast-dissolving clot is one of the proposed pathogenic mechanisms in Takotsubo cardiomyopathy (TC). HYPOTHESIS:The aim of this study was to seek evidence for the hypothesis of transient coronary thrombosis as the underlying mechanis...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20747
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:For decades, fasting for 8 to 12 hours has been recommended for measurement of lipid profiles. The effect of fasting on low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) has been described in healthy cohorts and those with stable disease states. Recently, guidelines suggested that fasting ma...
journal_title:Clinical cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/clc.22851
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Early recurrence of atrial fibrillation (ERAF) after catheter ablation is common and has been thoroughly studied. However, very late recurrence of atrial fibrillation (VLRAF) is rarely researched, and its characteristics have not been determined. HYPOTHESIS:The aim of this study was to investigate the clini...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20340
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Diabetic cardiomyopathy (DCMP) is a common complication of diabetes and is associated with increased mortality. It has been suggested that a poor R-wave progression in a resting electrocardiogram (ECG) could be a sign of cardiomyopathy. HYPOTHESIS:The aim of this study was primarily to analyze the relations...
journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.20810
更新日期:2010-09-01 00:00:00
abstract::201Thallium (201Tl) perfusion scintigraphy was performed in 22 patients with first acute transmural myocardial infarction within the initial 12 h after onset of symptoms. The size of the abnormally perfused area on 201Tl images was estimated by visual analysis and by a computer-assisted technique. 201Tl values for inf...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:In patients with stable angina pectoris, eccentric stenoses have a greater potential for dynamic changes of caliber in response to vasoactive stimuli than concentric lesions. It is not known whether in patients with coronary artery spasm the degree of coronary vasoconstriction differs in eccen...
journal_title:Clinical cardiology
pub_type: 临床试验,杂志文章
doi:10.1002/clc.4960210907
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND/HYPOTHESIS:SMARTWOMAN™ was designed to develop and assess the feasibility of a smartphone app to control cardiovascular risk factors in vulnerable diabetic women. METHODS:Fourteen African-American women with diabetes and without known cardiovascular disease were enrolled. A weight-scale, glucometer, sphygmo...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23124
更新日期:2019-02-01 00:00:00
abstract::Pathophysiology of malignant hypertension, of which underlying disease was essential hypertension (EHT) in 33 cases and chronic glomerulonephritis (CGN) in 26 cases, was studied with reference to the renin-angiotensin system. Plasma renin activity (PRA) was significantly higher in the EHT than in the CGN group, and an...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960100911
更新日期:1987-09-01 00:00:00
abstract::A patient with severe pulmonary hypertension secondary to the CREST syndrome variant of scleroderma is described. Acute reductions in both pulmonary artery pressure and total pulmonary resistance were seen with nifedipine and oxygen administration. Reductions in resistance were maintained for over one month with this ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960070111
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Acute changes in high-sensitivity troponin T (hs-TnT) are induced by myocardial ischemia during exercise stress testing, but there are no reports of pharmacological stress testing. HYPOTHESIS:The pattern of troponin release by myocardial ischemia-induced pharmacological stress testing differs according to t...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22392
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The finding of aortic regurgitation at a classical examination is a diastolic murmur. HYPOTHESIS:Aortic regurgitation is more likely to be associated with a systolic than with a diastolic murmur during routine screening by a noncardiologist physician. METHODS:In all, 243 asymptomatic patients (mean age 42 ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960270905
更新日期:2004-09-01 00:00:00
abstract::Remote ischemic preconditioning (RIPC) has been studied in models of different cardiovascular entities. Recently, a beneficial effect of RIPC on incidence of atrial fibrillation (AF) in postsurgical patients has been suggested. However, the potential impact of RIPC on electrophysiological- and thrombogenesis-related p...
journal_title:Clinical cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/clc.22584
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The relationship between eicosapentaenoic acid (EPA) therapy and coronary plaque stability assessed by optical frequency domain imaging (OFDI) has not been thoroughly described. HYPOTHESIS:EPA therapy is associated with decreased plaque instability in patients undergoing percutaneous coronary intervention (...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.23185
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND AND HYPOTHESIS:Although it is well established that diabetes mellitus (DM) induces more severe coronary artery disease (CAD), it is not known whether it contributes to the development of coronary collateral circulation. The present study examines coronary collateral circulation in diabetic and nondiabetic pa...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960220706
更新日期:1999-07-01 00:00:00
abstract::In patients with malignant ventricular arrhythmias, antiarrhythmic therapy is known to carry a substantial risk of proarrhythmia. This risk is usually considered to be low when supraventricular arrhythmias or benign ventricular arrhythmias are considered. We were able to collect data on four patients without a history...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170410
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Disruption of the atherosclerotic plaque is a common feature of both acute coronary syndromes and balloon dilatation of coronary artery stenoses. HYPOTHESIS:The study was undertaken to evaluate whether the known association of cholesterol levels and acute coronary syndromes also exists for the occurrence of...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4950260708
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Management of acute coronary syndrome (ACS) patients with nonobstructive epicardial coronary artery disease (CAD) remains poorly understood. HYPOTHESIS:Acute coronary syndrome patients with nonobstructive CAD are less likely to receive effective cardiac medications upon discharge from the hospital. METHODS...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.20701
更新日期:2010-01-01 00:00:00
abstract::Research protocols often utilize serial exercise testing to examine the efficacy of anti-ischemic therapies. These tests, however, are prone to multiple sources of bias. This investigation sought to determine the influence of varying precordial electrocardiographic (ECG) electrode placement on the detection of exercis...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960180409
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Prior studies suggest that the incidence of ventricular arrhythmias is high in patients with Fabry cardiomyopathy. This study evaluated the incidence of significant arrhythmias in a series of patients with Fabry cardiomyopathy. HYPOTHESIS:Arrhythmias are important causes of morbidity and mortality in Fabry ...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22047
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Due to sensorial autonomic neuropathy, the type and severity of angina pectoris in patients with diabetes mellitus (DM) may be rather different from the type and severity of angina pectoris in patients without DM. HYPOTHESIS:The aim of the study was to understand if angina pectoris is related to extensive c...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.22151
更新日期:2013-08-01 00:00:00
abstract::The purpose of this study was to investigate the efficacy of the patient-based coronary heart disease (CHD) risk management strategy in general practice by analyzing patients who were sent to a specialized center as refractory to conventional treatment. Of the 452 patients studied, 152 were excluded because of seconda...
journal_title:Clinical cardiology
pub_type: 杂志文章
doi:10.1002/clc.4960170305
更新日期:1994-03-01 00:00:00