Abstract:
:Remote ischemic preconditioning (RIPC) has been studied in models of different cardiovascular entities. Recently, a beneficial effect of RIPC on incidence of atrial fibrillation (AF) in postsurgical patients has been suggested. However, the potential impact of RIPC on electrophysiological- and thrombogenesis-related parameters in the setting of paroxysmal nonvalvular AF has not been investigated. The aim of the study is to answer the following questions: (1) Does RIPC have impact on inducibility of AF in patients with known paroxysmal AF? If yes, what are the direct electrophysiological mechanisms of this phenomenon, and could RIPC be implemented to reduce AF burden? (2) Does RIPC have the potential to minimize thrombogenic effects of simulated episodes of AF? If so, what are inhibited components of thrombogenesis and can this be used to reduce thromboembolic risk related to paroxysmal AF? The presented study is a 2-arm, randomized, placebo-controlled, double-blinded, single-center trial in a cohort of 146 patients with paroxysmal AF referred for AF ablation in sinus rhythm. The study will collect electrophysiological data such as variability of P-wave morphology, atrial refractory period, conduction times, and inducibility/sustainability of AF. Furthermore, AF-induced prothrombotic processes will be analyzed by quantification of platelet aggregates, analysis of platelet function, and measurement of thrombogenesis-related plasma markers. Moreover, the study will provide a unique bio-database for further analysis of molecular and genetic mechanisms responsible for observed results.
journal_name
Clin Cardioljournal_title
Clinical cardiologyauthors
Kosiuk J,Milani R,Ueberham L,Uhe T,Stegmann C,Hindricks G,Bollmann Adoi
10.1002/clc.22584subject
Has Abstractpub_date
2016-11-01 00:00:00pages
631-635issue
11eissn
0160-9289issn
1932-8737journal_volume
39pub_type
杂志文章,随机对照试验abstract::Patients with atrial fibrillation (AF) have an increased stroke risk compared with those in sinus rhythm, although the absolute risk for individual patients is modulated by the presence of various additional risk factors. Patient selection for oral anticoagulation for stroke prevention is based on risks of stroke and ...
journal_title:Clinical cardiology
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 临床试验,杂志文章
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更新日期:1997-01-01 00:00:00
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更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/clc.4960190514
更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/clc.4960230505
更新日期:2000-05-01 00:00:00
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更新日期:2002-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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