Hyponatremia in acute decompensated heart failure: mechanisms, prognosis, and treatment options.

Abstract:

:Hyponatremia is common and is increasingly recognized as an independent prognostic marker that adversely affects morbidity and mortality in various disease states, including heart failure. In acute decompensated heart failure (ADHF), the degree of hyponatremia often parallels the severity of cardiac dysfunction and is further exacerbated by any reduction in glomerular filtration rate and arginine vasopressin dysregulation. A recent study showed that even modest improvement of hyponatremia may have survival benefits. Although management of hyponatremia in ADHF has traditionally focused on improving cardiac function and fluid restriction, the magnitude of improvement of serum sodium is fairly slow and unpredictable. In this article, we discuss the mechanisms of hyponatremia in ADHF, review its evolving prognostic significance, and evaluate the efficacy of various treatments for hyponatremia, including the recently approved vasopressin receptor antagonists for managing hyponatremia among patients hospitalized for ADHF.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Jao GT,Chiong JR

doi

10.1002/clc.20822

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

666-71

issue

11

eissn

0160-9289

issn

1932-8737

journal_volume

33

pub_type

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