Partial fatty acid oxidation (pFOX) inhibition: a new therapy for chronic stable angina.

Abstract:

:During myocardial ischemia, fatty acids are the principal source of energy, increasing myocardial oxygen consumption and making a decrease in coronary blood flow less well tolerated. Increasing glucose oxidation during myocardial ischemia may improve cardiac efficiency. The pFOX inhibitors have the potential to accomplish this. In 2003, I think we can look forward to learning more about this class of compounds called pFOX inhibitors. Perhaps they will provide us alternative therapies in our patients who have persistent chronic stable angina pectoris despite aggressive medical therapy and/or revascularization. It seems to methat this is an increasing problem, and it is particularly common in older patients who want to remain active, but whose chronic stable angina interferes with that lifestyle.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Conti CR

doi

10.1002/clc.4960260402

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

161-2

issue

4

eissn

0160-9289

issn

1932-8737

journal_volume

26

pub_type

社论
  • N-terminal prohormone brain natriuretic peptide-proBNP levels in ventricular arrhythmias in children.

    abstract:BACKGROUND:Ventricular arrhythmias are the most common consequences of structural and functional heart diseases, but cases with no evident pathology are also observed. A parameter indicating asymptomatic circulatory failure could support decisions related to possible treatment of ventricular arrhythmias. HYPOTHESIS:Th...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20611

    authors: Mazurek B,Szydłowski L,Giec-Fuglewicz G,Markiewicz-Łoskot G

    更新日期:2009-12-01 00:00:00

  • Relation of body fluid status to B-type natriuretic peptide levels in patients with chronic heart failure during long-term follow-up.

    abstract:BACKGROUND:Little is known about the relationship of body fluid status with the levels and fluctuations of B-type natriuretic peptide (BNP) over the long-term. HYPOTHESIS:If BNP is to become useful for monitoring of patients with chronic heart failure (HF), the levels should reliably reflect both decompensation and im...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960291008

    authors: Kataoka H

    更新日期:2006-10-01 00:00:00

  • Regression of left ventricular mass in systemic hypertension.

    abstract::The importance of treatment in systemic hypertension and cardiovascular morbidity and mortality has been established. Although systemic hypertension is the most important factor in the pathogenesis of left ventricular hypertrophy, other factors such as catecholamines and renin-angiotensin system may be involved. Incre...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960150104

    authors: Georgiou D,Brundage BH

    更新日期:1992-01-01 00:00:00

  • Release of adenosine and lactate from human hearts during atrial pacing in patients with ischemic heart disease.

    abstract::Thirty-eight patients treated by atrial pacing were divided into three groups (Group I, patients with neither coronary stenosis nor anginal pain during pacing; Group II, patients with no coronary stenosis but having anginal pain during pacing; Group III, patients with coronary stenosis). The concentrations of adenosin...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960120203

    authors: Haneda T,Ichihara K,Abiko Y,Onodera S

    更新日期:1989-02-01 00:00:00

  • Antiarrhythmic drug therapy for atrial fibrillation: are the guidelines guiding clinical practice?

    abstract::The AFFIRM study showed no clear survival advantage for a rhythm versus rate control strategy in patients with atrial fibrillation (AF). However, rhythm control with antiarrhythmic drugs (AADs) is appropriate in a large number of patients with AF. The American College of Cardiology/ American Heart Association/European...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.4960290303

    authors: Reiffel JA,Naccarelli GV

    更新日期:2006-03-01 00:00:00

  • Correlates of bundle-branch block in patients undergoing primary angioplasty for acute myocardial infarction.

    abstract:BACKGROUND:Early reperfusion therapy has reduced the infarct size and mortality rate in patients with acute myocardial infarction (AMI). The occurrence of bundle-branch block in AMI is related to the amount of myocardial damage and the insult to the conduction system. HYPOTHESIS:To evaluate the clinical and angiograph...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960241204

    authors: Sugiura T,Yamasaki F,Hatada K,Nakamura S,Iwasaka T

    更新日期:2001-12-01 00:00:00

  • The clinical value of echocardiography and acoustic cardiography to monitor patients undergoing anthracycline chemotherapy.

    abstract:BACKGROUND:Investigate the usefulness of echocardiography and acoustic cardiography to monitor patients exposed to anthracycline chemotherapy. HYPOTHESIS:Serial echocardiographies to monitor systolic function may not be neccessary in all patients undergoing anthracycline chemotherapy. METHODS:In a prospective study, ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22074

    authors: Toggweiler S,Odermatt Y,Brauchlin A,Zander T,Müller A,Zuber M,Winterhalder R,Erne P

    更新日期:2013-04-01 00:00:00

  • Changes in inflammatory biomarkers in patients treated with ticagrelor or clopidogrel.

    abstract:BACKGROUND:Inflammation is a key factor in the development of atherosclerotic disease and acute coronary syndromes (ACS). The P2Y(12) receptor antagonists ticagrelor (AZD6140) and clopidogrel may have anti-inflammatory effects. The objective of this analysis from the Dose Confirmation Study Assessing Anti-Platelet Effe...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/clc.20732

    authors: Husted S,Storey RF,Harrington RA,Emanuelsson H,Cannon CP

    更新日期:2010-04-01 00:00:00

  • Hyponatremia in acute decompensated heart failure: mechanisms, prognosis, and treatment options.

    abstract::Hyponatremia is common and is increasingly recognized as an independent prognostic marker that adversely affects morbidity and mortality in various disease states, including heart failure. In acute decompensated heart failure (ADHF), the degree of hyponatremia often parallels the severity of cardiac dysfunction and is...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.20822

    authors: Jao GT,Chiong JR

    更新日期:2010-11-01 00:00:00

  • Association of conventional and exertional coronary heart disease risk factors in 5,000 apparently healthy men.

    abstract:BACKGROUND AND HYPOTHESIS:The aim of this study was to define the prevalence of previously undetected coronary heart disease among asymptomatic males, aged 30-65 years, by means of resting and exercise electrocardiography in conjunction with an analysis of conventional and exertional coronary risk factors. METHODS:Bet...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960190405

    authors: Davies B,Ashton WD,Rowlands DJ,eL-Sayed M,Wallace PC,Duckett K,Coley J,Daggett AM

    更新日期:1996-04-01 00:00:00

  • Peripheral levels of matrix metalloproteinase-9, interleukin-6, and C-reactive protein are elevated in patients with acute coronary syndromes: correlations with serum troponin I.

    abstract:BACKGROUND:Acute coronary syndromes (ACS) are characterized by activation of systemic and local inflammatory mediators. The interrelation between these soluble inflammatory markers and their association with markers of myocardial necrosis have not been extensively studied. HYPOTHESIS:The study was undertaken to evalua...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960280405

    authors: Manginas A,Bei E,Chaidaroglou A,Degiannis D,Koniavitou K,Voudris V,Pavlides G,Panagiotakos D,Cokkinos DV

    更新日期:2005-04-01 00:00:00

  • Method for noninvasive measurement of central aortic systolic pressure.

    abstract::A method for noninvasive generation of central aortic systolic pressure curves is presented. The method is based on plotting the occlusive pressure values applied at the brachial artery level against the time intervals needed for the aortic pressure wave to equalize and break through the occlusive pressure at the brac...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960100402

    authors: Marmor AT,Blondheim DS,Gozlan E,Navo E,Front D

    更新日期:1987-04-01 00:00:00

  • Effect of balloon inflation-induced acute ischemia on QT dispersion during percutaneous transluminal coronary angioplasty.

    abstract:BACKGROUND:QT dispersion (QTd = QTmax-QTmin) measured as interlead variability of QT interval reflects the spatial inhomogeneity of ventricular repolarization times, and increased QTd may provide a substrate for malignant ventricular arrhythmias. Ischemia is associated with regional abnormalities of conduction and repo...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960220109

    authors: Aytemir K,Bavafa V,Ozer N,Aksoyek S,Oto A,Ozmen F

    更新日期:1999-01-01 00:00:00

  • Left ventricular mass assessed by three-dimensional echocardiography using rotational acquisition.

    abstract:BACKGROUND:The reproducibility of left ventricular (LV) mass measurement by two-dimensional (2-D) echocardiography is inadequate for individual assessments. HYPOTHESIS:This study was undertaken to evaluate the potential of LV mass determination with a new three-dimensional (3-D) echocardiographic method compared with ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960201111

    authors: Rodevand O,Bjornerheim R,Kolbjornsen O,Ihlen H,Kjekshus J

    更新日期:1997-11-01 00:00:00

  • Hemophilus influenzae pericarditis.

    abstract::Although Hemophilus influenzae infections have long been considered to be a disease of childhood, recent reports have demonstrated an increasing frequency of serious Hemophilus influenzae infections in adults. A case of purulent H. influenzae pericarditis in a previously healthy adult without evidence of concurrent H....

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960051008

    authors: Sink JD,Spray TL,Rankin JS

    更新日期:1982-10-01 00:00:00

  • Right atrial function by speckle tracking echocardiography in atrial septal defect: Prediction of atrial fibrillation.

    abstract:BACKGROUND:Most antiarrhythmic interventional therapies for atrial fibrillation (AF) have been provided with special focus on the treatment of left-sided valvular disease and enlarged left atrium but few studies have assessed AF associated with congenital heart disease and dilated right atrium. HYPOTHESIS:We hypothesi...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.23051

    authors: Vitarelli A,Mangieri E,Gaudio C,Tanzilli G,Miraldi F,Capotosto L

    更新日期:2018-10-01 00:00:00

  • Acute myocardial infarction with normal coronary arteries. In vivo demonstration of coronary thrombosis during the acute episode.

    abstract::Two cases with acute myocardial infarction are presented. Both had thrombotic occlusion of the infarct-related artery. Following successful thrombolysis with streptokinase, coronary angiography was normal. These cases prove that "myocardial infarction with normal coronaries" can be associated with coronary thrombosis ...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960061107

    authors: Fernandez MS,Pichard AD,Marchant E,Lindsay J Jr

    更新日期:1983-11-01 00:00:00

  • Echocardiographic and hemodynamic features of severe aortic regurgitation with diastolic opening of the aortic valve.

    abstract::Severe aortic regurgitation may be associated with premature aortic valve opening. Several possible etiologies for this diastolic opening have been suggested. We present a patient with hemodynamic data, M-mode and 2-D echocardiography in the setting of severe aortic regurgitation and diastolic aortic valve opening. Ou...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960090513

    authors: Martinez EE,Herman MV,Kay RH,Pontes SC Jr,Brandao AC,Pfefferman A,Arroyo JB,Portugal OP

    更新日期:1986-05-01 00:00:00

  • The prevalence of prehypertension and hypertension among rural adults in Liaoning province of China.

    abstract:BACKGROUND:The objective of this study was to estimate the prevalence of prehypertension and hypertension in the rural adults of Liaoning province of China. METHODS:The study was conducted in 2004-2006, using a multistage cluster sampling method to select a representative sample. A total of 45925 adults, 35 years or o...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20073

    authors: Sun Z,Zheng L,Wei Y,Li J,Zhang X,Zhang X,Liu S,Xu C,Li J,Zhao F,Dong G,Hu D,Sun Y

    更新日期:2007-04-01 00:00:00

  • Endothelial function, fibrinolysis, and angiotensin-converting enzyme inhibition.

    abstract::Experimental and clinical studies with angiotensin-converting enzyme (ACE) inhibitors have suggested that these agents may reduce the risk of atherothrombotic events. Recent studies have identified the role of angiotensin II and ACE in the regulation of fibrinolysis. There is now substantial evidence that the renin-an...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Vaughan DE

    更新日期:1997-11-01 00:00:00

  • Electrocardiographic findings in peripartum cardiomyopathy.

    abstract:BACKGROUND:There is limited data on electrocardiographic (ECG) abnormalities and their prognostic significance in women with peripartum cardiomyopathy (PPCM). We sought to characterize ECG findings in PPCM and explore the association of ECG findings with myocardial recovery and clinical outcomes. HYPOTHESIS:We hypothe...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/clc.23171

    authors: Honigberg MC,Elkayam U,Rajagopalan N,Modi K,Briller JE,Drazner MH,Wells GL,McNamara DM,Givertz MM,IPAC Investigators.

    更新日期:2019-05-01 00:00:00

  • Factors associated with the release of cardiac troponin T following percutaneous transluminal coronary angioplasty.

    abstract:BACKGROUND:Recent studies have suggested that immunoassay of cardiac troponin T (cTnT) provides a more sensitive measurement of myocardial necrosis than creatine kinase MB (CK-MB) mass concentration. HYPOTHESIS:The purpose of this study was to compare the release of cTnT and CK-MB isoenzyme in patients undergoing perc...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960191005

    authors: Abbas SA,Glazier JJ,Wu AH,Dupont C,Green SF,Pearsall LA,Waters DD,McKay RG

    更新日期:1996-10-01 00:00:00

  • Heart rate variability during repeated incremental head-up tilt discloses time dependence of individual autonomic dynamics.

    abstract::According to the Rosenblueth-Simeone model, the heart rate (HR) is proportional to the sympathovagal balance. The individual proportionality constant is the intrinsic HR, which can be determined only invasively. The percentage low-frequency spectral HR variability power, relative to the low- plus high-frequency spectr...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960190112

    authors: Bootsma M,Swenne CA,Bruschke AV

    更新日期:1996-01-01 00:00:00

  • Predictors of Medical Management in Patients Undergoing Elective Cardiac Catheterization for Chronic Ischemic Heart Disease.

    abstract:BACKGROUND:Compared with medical therapy, percutaneous coronary intervention (PCI) does not reduce mortality or myocardial infarction in patients with stable angina. Therefore, PCI should be guided by refractory anginal symptoms and not just lesion characteristics. HYPOTHESIS:We hypothesized that angiographic lesion c...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.22510

    authors: Atreya AR,Sivalingam SK,Arora S,Kashef MA,Fitzgerald J,Visintainer P,Lotfi A,Rothberg MB

    更新日期:2016-04-01 00:00:00

  • Complete absence of pulmonary veins.

    abstract::Various types of pulmonary venous return abnormalities have been described in the literature. This report presents a case in which a 4-h-old neonate presented with cyanotic heart disease and respiratory distress. This neonate was subsequently shown to have complete absence of the pulmonary veins (CAPV), a previously u...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960110415

    authors: Ralston MA,Teske DW

    更新日期:1988-04-01 00:00:00

  • Mitral valve prolapse causing severe mitral regurgitation in a patient with absent right pulmonary artery.

    abstract::A 33-year-old man was investigated for dyspnea on exertion and the presence of a pansystolic murmur. Physical examination revealed dextrocardia confirmed by chest radiograph, which also showed oligemic right lung field. Subsequent cardiac catheterization revealed secundum atrial septal defect, persistent left sided su...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960180713

    authors: Yip AS,Chow WH,Lee DF,Cheung KL

    更新日期:1995-07-01 00:00:00

  • Detection of viable myocardium using coronary angiography and ventriculography.

    abstract::In 2002, coronary angiography is the only way to assess precisely the combination of proximal stenoses, distal target vessels, collaterals, microcirculation, and TIMI antegrade flow. At the time of coronary angiography, global LV function is best determined using biplane ventriculography in order to correlate wall mot...

    journal_title:Clinical cardiology

    pub_type: 社论

    doi:10.1002/clc.4950250802

    authors: Conti CR

    更新日期:2002-08-01 00:00:00

  • Appearance of electrocardiographic initial U-wave inversion dependent on pressure-induced early diastolic impairment in patients with hypertension.

    abstract:BACKGROUND:ECG U-wave inversion can be classified as initial and terminal U inversion according to the phasic relationship to positive U-wave deflection. Initial U inversion is occasionally observed in hypertensive patients while terminal U inversion frequently appears during severe myocardial ischemia. HYPOTHESIS:The...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.20487

    authors: Miwa K

    更新日期:2009-10-01 00:00:00

  • Embolus to the right atrium simulating myxoma.

    abstract::A space-occupying mass of the right atrium was found by two-dimensional echocardiography and angiography in a 68-year-old woman whose clinical diagnosis indicated multiple pulmonary emboli. Since right heart myxomas frequently cause pulmonary thromboembolism, the patient was initially diagnosed by noninvasive and inva...

    journal_title:Clinical cardiology

    pub_type: 杂志文章

    doi:10.1002/clc.4960070113

    authors: Buckingham TA,Williams GA,Aker UT,Kennedy HL

    更新日期:1984-01-01 00:00:00

  • Valve-in-valve transcatheter aortic valve replacement to treat multijet paravalvular regurgitation: A case series and review.

    abstract::Treatment advances for severe symptomatic aortic stenosis including transcatheter and open surgical valve replacement have improved patient survival, length of stay, and speed to recovery. However, paravalvular regurgitation (PVR) is occasionally seen and when moderate or greater in severity is associated with an at l...

    journal_title:Clinical cardiology

    pub_type: 杂志文章,评审

    doi:10.1002/clc.23504

    authors: Randall MH,Lewandowski TJ,Choi C,Beaver TM

    更新日期:2021-01-01 00:00:00