Dietary vitamin E levels affect outcome of permanent focal cerebral ischemia in rats.

Abstract:

BACKGROUND AND PURPOSE:A supraphysiological amount of vitamin E in the standard diet of laboratory animals may provide partial protection against cerebral ischemic damage in stroke models. The aim of the present study was to test the effect of dietary vitamin E on infarct volume in rats subjected to permanent focal cerebral ischemia. METHODS:Male Wistar rats were raised on a vitamin E-deficient diet (n=10) or a control diet containing 62.7 mg vitamin E/kg (n=11) for 13 to 16 weeks, from the age of 3 weeks. The left middle cerebral artery (MCA) was permanently occluded by means of an intraluminal silicone-coated 3-0 suture. Blood flow in the left MCA territory was measured before and after occlusion with laser Doppler flowmetry. The area of infarction was measured in hematoxylin-eosin-stained brain sections by means of an image analysis system. The investigator was not aware of the vitamin E status of the rats. RESULTS:Blood flow in the left MCA territory in the second half hour after occlusion was 43+/-17% and 42+/-17% (mean+/-SD) of the baseline value in control and vitamin E-deficient rats, respectively. The mean infarct volume, measured after 48 hours of survival, was 61+/-19 mm3 in control rats and 137+/-76 mm3 in vitamin E-deficient rats (P=0.037). CONCLUSIONS:After permanent focal cerebral ischemia, the infarct is larger in vitamin E-deficient rats than in rats raised on a diet with the usual, supraphysiological amount of vitamin E. This may have consequences for cerebral ischemia studies with experimental animals.

journal_name

Stroke

journal_title

Stroke

authors

van der Worp HB,Bär PR,Kappelle LJ,de Wildt DJ

doi

10.1161/01.str.29.5.1002

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

1002-5; discussion 1005-6

issue

5

eissn

0039-2499

issn

1524-4628

journal_volume

29

pub_type

杂志文章

相关文献

STROKE文献大全
  • Occurrence and clinical impact of microembolic signals during or after cardiosurgical procedures.

    abstract:BACKGROUND AND PURPOSE:Microembolic signals (MESs) are detectable within the transcranial Doppler frequency spectrum downstream from vascular atherothrombotic or cardiothrombotic lesions. A frequent occurrence of MESs has also been shown during bypass surgery or after mechanical valve implantation. We sought to compile...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/STROKEAHA.107.491241

    authors: Dittrich R,Ringelstein EB

    更新日期:2008-02-01 00:00:00

  • Incidence of transient ischemic attack in Rochester, Minnesota, 1985-1989.

    abstract:BACKGROUND AND PURPOSE:There is scant information available on the incidence of transient ischemic attack (TIA) in a defined population. This study defines incidence rates of first TIA and subtypes of TIA during 1985-1989 and compares the incidence to that obtained from a 1960-1972 cohort study. METHODS:Medical record...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.10.2109

    authors: Brown RD Jr,Petty GW,O'Fallon WM,Wiebers DO,Whisnant JP

    更新日期:1998-10-01 00:00:00

  • Influence of weekend hospital admission on short-term mortality after intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:There is expanding literature to show that certain patients admitted during the weekend have worse outcomes than similar patients admitted during the week. Although many clinicians have hypothesized the presence of this "weekend effect" with patients with intracerebral hemorrhage, there is a pauc...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.546572

    authors: Crowley RW,Yeoh HK,Stukenborg GJ,Medel R,Kassell NF,Dumont AS

    更新日期:2009-07-01 00:00:00

  • Intracerebral hemorrhage in the very old: future demographic trends of an aging population.

    abstract:BACKGROUND AND PURPOSE:In most European societies and in the United States, the percentage of patients ≥80 years has been rising over the past century. The present study was conducted to observe this demographic change and its impact on patients with intracerebral hemorrhage (ICH). METHODS:We reviewed patients' data w...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.644716

    authors: Stein M,Misselwitz B,Hamann GF,Scharbrodt W,Schummer DI,Oertel MF

    更新日期:2012-04-01 00:00:00

  • Establishing Recommendations for Stroke Systems in the Thrombectomy Era: The Upstate New York Stakeholder Proceedings.

    abstract:BACKGROUND AND PURPOSE:The American Heart Association/American Stroke Association and Department of Health Stroke Coverdell Program convened a stakeholder meeting in upstate NY to develop recommendations to enhance stroke systems for acute large vessel occlusion. METHODS:Prehospital, hospital, and Department of Health...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.017412

    authors: Magdon-Ismail Z,Benesch C,Cushman JT,Brissette I,Southerland AM,Brandler ES,Sozener CB,Flor S,Hemmitt R,Wales K,Parrigan K,Levine SR,Upstate New York Stroke Work Groups.

    更新日期:2017-07-01 00:00:00

  • Urinary incontinence after stroke: identification, assessment, and intervention by rehabilitation professionals in Canada.

    abstract:BACKGROUND AND PURPOSE:Urinary incontinence (UI) is a common and distressing problem after stroke. Although there is evidence of new, effective UI poststroke rehabilitation intervention, it is unknown whether occupational therapists (OTs)' and physical therapists (PTs)' actual practices reflect best practices. We sough...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.486035

    authors: Dumoulin C,Korner-Bitensky N,Tannenbaum C

    更新日期:2007-10-01 00:00:00

  • Cigarette smoking and risk of stroke in the chinese adult population.

    abstract:BACKGROUND AND PURPOSE:We studied the relationship between cigarette smoking and stroke incidence and mortality in the Chinese adult population. METHODS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged 40 years and older. Data on cigarette smoking and ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.505305

    authors: Kelly TN,Gu D,Chen J,Huang JF,Chen JC,Duan X,Wu X,Chen CS,He J

    更新日期:2008-06-01 00:00:00

  • Trends in 10-year survival of patients with stroke hospitalized between 1980 and 2000: the Minnesota stroke survey.

    abstract:BACKGROUND AND PURPOSE:We report on trends in poststroke survival, both in the early period after stroke and over the long term. We examine these trends by stroke subtype. METHODS:The Minnesota Stroke Survey is a study of all hospitalized patients with acute stroke aged 30 to 74 years in the Minneapolis-St Paul metrop...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.005512

    authors: Lakshminarayan K,Berger AK,Fuller CC,Jacobs DR Jr,Anderson DC,Steffen LM,Sillah A,Luepker RV

    更新日期:2014-09-01 00:00:00

  • The influence of depression, social activity, and family stress on functional outcome after stroke.

    abstract:BACKGROUND AND PURPOSE:This study was designed to assess the quality of life after an active poststroke period of rehabilitation and to investigate the possibility of a return to a working environment for those still of working age. METHODS:The study was conducted on 180 consecutive patients affected by stroke who wer...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.10.1478

    authors: Angeleri F,Angeleri VA,Foschi N,Giaquinto S,Nolfe G

    更新日期:1993-10-01 00:00:00

  • Relation between cerebral perfusion territories and location of cerebral infarcts.

    abstract:BACKGROUND AND PURPOSE:The perfusion territories of the brain-feeding arteries are difficult to assess in vivo and therefore standard cerebral perfusion territory templates are often used to determine the relation between cerebral infarcts and the feeding vasculature. In the present study, we compared this infarct clas...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.539866

    authors: Hendrikse J,Petersen ET,Chèze A,Chng SM,Venketasubramanian N,Golay X

    更新日期:2009-05-01 00:00:00

  • ICES (Intraoperative Stereotactic Computed Tomography-Guided Endoscopic Surgery) for Brain Hemorrhage: A Multicenter Randomized Controlled Trial.

    abstract:BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating disease without a proven therapy to improve long-term outcome. Considerable controversy about the role of surgery remains. Minimally invasive endoscopic surgery for ICH offers the potential of improved neurological outcome. METHODS:We tested the hy...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.116.013837

    authors: Vespa P,Hanley D,Betz J,Hoffer A,Engh J,Carter R,Nakaji P,Ogilvy C,Jallo J,Selman W,Bistran-Hall A,Lane K,McBee N,Saver J,Thompson RE,Martin N,ICES Investigators.

    更新日期:2016-11-01 00:00:00

  • Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study.

    abstract:BACKGROUND AND PURPOSE:Preclinical data suggest that cell-based therapies have the potential to improve stroke outcomes. METHODS:Eighteen patients with stable, chronic stroke were enrolled in a 2-year, open-label, single-arm study to evaluate the safety and clinical outcomes of surgical transplantation of modified bon...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.012995

    authors: Steinberg GK,Kondziolka D,Wechsler LR,Lunsford LD,Coburn ML,Billigen JB,Kim AS,Johnson JN,Bates D,King B,Case C,McGrogan M,Yankee EW,Schwartz NE

    更新日期:2016-07-01 00:00:00

  • Transient aortic arch syndrome with dysphasia due to ergotism.

    abstract::A 55-year-old woman with an aortic arch syndrome of acute onset and dysphasia, resulting from the excessive administration of ergotamine tartrate suppositories, is described. Complete resolution of symptoms and return of upper limb and carotid artery pulses to normal occurred within four days of cessation of the ergot...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.5.811

    authors: Feneley MP,Morgan JJ,McGrath MA,Egan JD

    更新日期:1983-09-01 00:00:00

  • Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging.

    abstract:BACKGROUND:The ability to quickly and efficiently identify the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Early and accurate identification of potentially salvageable versus irreversibly infarcted brain tissue may enable selection of the most appro...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.STR.0000097608.38779.CC

    authors: Kidwell CS,Alger JR,Saver JL

    更新日期:2003-11-01 00:00:00

  • Noninvasive assessment of cerebral collateral blood supply through the ophthalmic artery.

    abstract::We assessed the potential of 2-MHz pulsed-wave transorbital Doppler ultrasonography to delineate the role of the ophthalmic artery as a source of collateral cerebral blood supply by comparing oculopneumoplethysmography, transorbital Doppler ultrasonography, periorbital continuous-wave Doppler ultrasonography, and tran...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.22.1.31

    authors: Schneider PA,Rossman ME,Bernstein EF,Ringelstein EB,Otis SM

    更新日期:1991-01-01 00:00:00

  • Update of the stroke therapy academic industry roundtable preclinical recommendations.

    abstract::The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to improve the quality of preclinical studies of purported acute stroke therapies. Although recognized as reasonable, they have not been closely followed nor rigorously validated. Substantial advances have o...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/STROKEAHA.108.541128

    authors: Fisher M,Feuerstein G,Howells DW,Hurn PD,Kent TA,Savitz SI,Lo EH,STAIR Group.

    更新日期:2009-06-01 00:00:00

  • Detection of thrombus in acute ischemic stroke: value of thin-section noncontrast-computed tomography.

    abstract:BACKGROUND AND PURPOSE:Previous studies on the hyperdense middle cerebral artery (MCA) sign were conducted using > or =5-mm thickness noncontrast-computed tomography (NCT). The purpose of this study was to compare thin-section NCT with 5-mm NCT in the detection of thrombus in acute ischemic stroke. METHODS:Enrolled we...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000185720.03803.41

    authors: Kim EY,Lee SK,Kim DJ,Suh SH,Kim J,Heo JH,Kim DI

    更新日期:2005-12-01 00:00:00

  • Stereotactic treatment of intracerebral hematoma by means of a plasminogen activator: a multicenter randomized controlled trial (SICHPA).

    abstract:BACKGROUND AND PURPOSE:Treatment of intracerebral hematoma (ICH) is controversial. An advantage of neurosurgical intervention over conservative treatment of ICH has not been established. Recent reports suggest a favorable effect of stereotactic blood clot removal after liquefaction by means of a plasminogen activator. ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.STR.0000063367.52044.40

    authors: Teernstra OP,Evers SM,Lodder J,Leffers P,Franke CL,Blaauw G,Multicenter randomized controlled trial (SICHPA).

    更新日期:2003-04-01 00:00:00

  • Blend Sign on Computed Tomography: Novel and Reliable Predictor for Early Hematoma Growth in Patients With Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Early hematoma growth is not uncommon in patients with intracerebral hemorrhage and is an independent predictor of poor functional outcome. The purpose of our study was to report and validate the use of our newly identified computed tomographic (CT) blend sign in predicting early hematoma growth....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.009185

    authors: Li Q,Zhang G,Huang YJ,Dong MX,Lv FJ,Wei X,Chen JJ,Zhang LJ,Qin XY,Xie P

    更新日期:2015-08-01 00:00:00

  • Effect of intracarotid prostaglandin E1 on regional cerebral blood flow in man.

    abstract::The effect of prostaglandin E1 on regional cerebral blood flow (rCBF) was studied with the intra-arterial 133Xe method in ten awake patients under local anesthesia. Measurements were taken from 16 areas of a hemisphere in seven patients, from 35 areas of a hemisphere in two patients and from 256 areas of a hemisphere ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.7.6.566

    authors: Olesen J

    更新日期:1976-11-01 00:00:00

  • Characteristics of intracerebral hemorrhage during rivaroxaban treatment: comparison with those during warfarin.

    abstract:BACKGROUND AND PURPOSE:Neuroradiological characteristics and functional outcomes of patients with intracerebral hemorrhage (ICH) during novel oral anticoagulant treatment were not well defined. We examined these in comparison with those during warfarin treatment. METHODS:The consecutive 585 patients with ICH admitted ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.006661

    authors: Hagii J,Tomita H,Metoki N,Saito S,Shiroto H,Hitomi H,Kamada T,Seino S,Takahashi K,Baba Y,Sasaki S,Uchizawa T,Iwata M,Matsumoto S,Osanai T,Yasujima M,Okumura K

    更新日期:2014-09-01 00:00:00

  • Decreased glomerular filtration rate is a risk factor for hemorrhagic but not for ischemic stroke: the Rotterdam Study.

    abstract:BACKGROUND AND PURPOSE:Persons with early stages of chronic kidney disease, defined by a decreased glomerular filtration rate (GFR), have an increased risk of cardiovascular disease. It is unclear whether decreased GFR is a risk factor for stroke. We assessed the association between GFR and stroke in a prospective popu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.489807

    authors: Bos MJ,Koudstaal PJ,Hofman A,Breteler MM

    更新日期:2007-12-01 00:00:00

  • Acute effects of isovolemic hemodilution with crystalloids in a canine model of focal cerebral ischemia.

    abstract::We used 44 splenectomized dogs to study the effects of isovolemic hemodilution with a crystalloid solution. The dogs were randomly divided into a hemodilution and a control group. In each group, 17 dogs were subjected to 6 hours of internal carotid and middle cerebral artery occlusion, and five dogs received sham oper...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.4.534

    authors: Hyodo A,Heros RC,Tu YK,Ogilvy C,Graichen R,Lagree K,Korosue K

    更新日期:1989-04-01 00:00:00

  • Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:The integrin-linked kinase (ILK) signaling pathway contributes to regulation of cellular adhesion, migration, and differentiation, and to apoptotic cell death after a variety of cell death stimuli. We have reported that overexpression of copper/zinc superoxide dismutase (SOD1) reduces apoptotic c...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000144653.32853.ed

    authors: Saito A,Hayashi T,Okuno S,Nishi T,Chan PH

    更新日期:2004-11-01 00:00:00

  • Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results.

    abstract:BACKGROUND AND PURPOSE:A previous trial (the Clomethiazole Acute Stroke Study) generated the hypothesis that clomethiazole is effective in patients with a major ischemic stroke (total anterior circulation syndrome), and this was tested in the present study. METHODS:A total of 1198 patients with major ischemic stroke a...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/hs0102.101478

    authors: Lyden P,Shuaib A,Ng K,Levin K,Atkinson RP,Rajput A,Wechsler L,Ashwood T,Claesson L,Odergren T,Salazar-Grueso E,CLASS-I\/H\/T Investigators.

    更新日期:2002-01-01 00:00:00

  • The concept of patient motivation: a qualitative analysis of stroke professionals' attitudes.

    abstract:BACKGROUND AND PURPOSE:The purpose of this work was to investigate how stroke rehabilitation professionals understand the concept of motivation and the ways that they use this concept in their clinical practice. METHODS:This qualitative study used semistructured, in-depth interviews with the professionals working in t...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0202.102367

    authors: Maclean N,Pound P,Wolfe C,Rudd A

    更新日期:2002-02-01 00:00:00

  • Localized retinal nerve fiber layer defects and stroke.

    abstract:BACKGROUND AND PURPOSE:Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). METHODS:Patients with acute ischemic stroke as part of a hospital-based study group were compared with t...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.113.004629

    authors: Wang D,Li Y,Wang C,Xu L,You QS,Wang YX,Zhao L,Wei WB,Zhao X,Jonas JB

    更新日期:2014-06-01 00:00:00

  • Glucagon-Like Peptide-1 Receptor Agonists and Prevention of Stroke Systematic Review of Cardiovascular Outcome Trials With Meta-Analysis.

    abstract::Background and Purpose- The purpose of this study was to conduct a meta-analysis of CVOTs (cardiovascular outcome trials) to evaluate the effect of glucagon-like peptide-1 receptor agonists therapy in reducing the risk of stroke in patients with type 2 diabetes mellitus. Methods- PubMed and other electronic sources we...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.119.027557

    authors: Bellastella G,Maiorino MI,Longo M,Scappaticcio L,Chiodini P,Esposito K,Giugliano D

    更新日期:2020-02-01 00:00:00

  • Plaque distribution of stenotic middle cerebral artery and its clinical relevance.

    abstract:BACKGROUND AND PURPOSE:Microanatomy studies reveal that most penetrating branches of middle cerebral artery (MCA) arise from the dorsal-superior surface of the trunk. Using high-resolution MRI, we sought to explore the plaque distribution of MCA atherosclerosis and its clinical relevance in relation to the orifices of ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.618132

    authors: Xu WH,Li ML,Gao S,Ni J,Zhou LX,Yao M,Peng B,Feng F,Jin ZY,Cui LY

    更新日期:2011-10-01 00:00:00

  • Effect of DPPD (diphenyl-para-phenylenediamine) on stroke and cerebral edema in gerbils.

    abstract::Diphenyl-para-phenylenediamine (DPPD) is an antioxidant that has been shown to decrease liver damage due to the peroxidative process of carbon tetrachloride in rats and to ameliorate cold-induced cerebral edema in cats. Because lipid peroxidation disrupts the integrity of the plasma membrane, a process believed to occ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.9.5.480

    authors: Butterfield JD,McGraw CP

    更新日期:1978-09-01 00:00:00