Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains.

abstract：:Human CD81 has been previously identified as the putative receptor for the hepatitis C virus envelope glycoprotein E2. The large extracellular loop (LEL) of human CD81 differs in four amino acid residues from that of the African green monkey (AGM), which does not bind E2. We mutated each of the four positions in human...

journal_title：Journal of virology

authors： Higginbottom A,Quinn ER,Kuo CC,Flint M,Wilson LH,Bianchi E,Nicosia A,Monk PN,McKeating JA,Levy S

更新日期：2000-04-01 00:00:00

abstract：:The phosphoprotein (P) of the nonsegmented negative-sense RNA viruses is a multimeric modular protein that is essential for RNA transcription and replication. Despite great variability in length and sequence, the architecture of this protein is conserved among the different viral families, with a long N-terminal intri...

journal_title：Journal of virology

authors： Gérard FCA,Jamin M,Blackledge M,Blondel D,Bourhis JM

更新日期：2020-02-28 00:00:00

abstract：:Following its entry into cells, pseudorabies virus (PRV) utilizes microtubules to deliver its nucleocapsid to the nucleus. Previous studies have shown that PRV VP1/2 is an effector of dynein-mediated capsid transport. However, the mechanism of PRV for recruiting microtubule motor proteins for successful neuroinvasion ...

journal_title：Journal of virology

authors： Yan K,Liu J,Guan X,Yin YX,Peng H,Chen HC,Liu ZF

更新日期：2019-03-21 00:00:00

abstract：:Using a yeast two-hybrid screen of a T-cell cDNA library to identify cellular proteins that bind to the human immunodeficiency virus type 2 (HIV-2) Gag polyprotein, we identified PRP4, a serine-threonine protein kinase. Specific interaction of PRP4 and HIV-2 Gag was confirmed in in vitro and in vivo assays. The intera...

journal_title：Journal of virology

authors： Bennett EM,Lever AM,Allen JF

更新日期：2004-10-01 00:00:00

abstract：:Escherichia coli K-12 wild type and a uvrA mutant derivative were used to construct isogenic strains bearing one, two, three, or more phage lambda cI genomes and containing increasing concentration of lambda repressor as measured by in vitro operator DNA-binding assays. The survival and phage induction in response to ...

journal_title：Journal of virology

authors： Baluch J,Sussman R

更新日期：1978-06-01 00:00:00

abstract：:The reovirus core particle is a molecular machine that mediates synthesis, capping, and export of the viral plus strand RNA transcripts. Its assembly and structure-function relationships remain to be well understood. Following the lead of previous studies with other Reoviridae family members, most notably orbiviruses ...

journal_title：Journal of virology

authors： Kim J,Zhang X,Centonze VE,Bowman VD,Noble S,Baker TS,Nibert ML

更新日期：2002-12-01 00:00:00

abstract：:The hepatitis C virus (HCV) core gene is more conserved at the nucleic acid level than is necessary to preserve the sequence of the core protein, suggesting that it contains information for additional functions. We used a battery of anticore antibodies to test the hypothesis that the core gene directs the synthesis of...

journal_title：Journal of virology

authors： Eng FJ,Walewski JL,Klepper AL,Fishman SL,Desai SM,McMullan LK,Evans MJ,Rice CM,Branch AD

更新日期：2009-04-01 00:00:00

abstract：:Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have spread throughout Europe, and serotype 8 has suddenly emerged in northern Europe, causing considerable economic losses, direct (mortality and morbidity) but also indirect, due to restriction in animal movements. Therefore, many new types of vaccines, par...

journal_title：Journal of virology

authors： Celma CC,Boyce M,van Rijn PA,Eschbaumer M,Wernike K,Hoffmann B,Beer M,Haegeman A,De Clercq K,Roy P

更新日期：2013-09-01 00:00:00

abstract：:Streptomyces coelicolor is a model system for the study of Streptomyces, a genus of bacteria responsible for the production of many clinically important antibiotics. Here we report the genome sequence of ΦCAM, a new S. coelicolor generalized transducing bacteriophage, isolated from a soil sample originating from Linco...

journal_title：Journal of virology

authors： Monson R,Salmond GP

更新日期：2012-12-01 00:00:00

abstract：:The alphavirus Semliki Forest virus (SFV) infects cells through low-pH-induced membrane fusion mediated by the E1 protein, a class II virus membrane fusion protein. During fusion, E1 inserts into target membranes via its hydrophobic fusion loop and refolds to form a stable E1 homotrimer. Mutation of a highly conserved...

journal_title：Journal of virology

authors： Chanel-Vos C,Kielian M

更新日期：2006-06-01 00:00:00

abstract：:White spot syndrome virus (WSSV) occurs worldwide and causes high mortality and considerable economic damage to the shrimp farming industry. No adequate treatments against this virus are available. It is generally accepted that invertebrates such as shrimp do not have an adaptive immune response system such as that pr...

journal_title：Journal of virology

authors： Witteveldt J,Cifuentes CC,Vlak JM,van Hulten MC

更新日期：2004-02-01 00:00:00

abstract：:Receptors (FcgammaRs) for the constant region of immunoglobulin G (IgG) are an important link between humoral immunity and cellular immunity. To help define the role of FcgammaRs in determining the fate of human immunodeficiency virus type 1 (HIV-1) immune complexes, cDNAs for the four major human Fcgamma receptors (F...

journal_title：Journal of virology

authors： Perez LG,Costa MR,Todd CA,Haynes BF,Montefiori DC

更新日期：2009-08-01 00:00:00

abstract：:Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore, we studied PD-1 expression longitudinally during acute HCV infection. Most HCV-specific CD8 cells expressed PD-1 at the...

journal_title：Journal of virology

authors： Urbani S,Amadei B,Tola D,Massari M,Schivazappa S,Missale G,Ferrari C

更新日期：2006-11-01 00:00:00

abstract：:We have established a genetic assay for the multimerization of retroviral gag polyproteins. This assay is based on the GAL4 two-hybrid system for studying protein-protein interactions (S. Fields and O. Song, Nature (London) 340:245-246, 1989). In our initial experiments, we generated Saccharomyces cerevisiae plasmids ...

journal_title：Journal of virology

authors： Luban J,Alin KB,Bossolt KL,Humaran T,Goff SP

更新日期：1992-08-01 00:00:00

abstract：:Utilizing the isolated left and right halves of both adenovirus type 2 and the nondefective adenovirus simian virus 40 hybrid (Ad2(+)ND(1)), studies were undertaken to find the site on the DNA molecules at which replication begins. The data are consistent with several models which include an initiation event at both e...

journal_title：Journal of virology

authors： Horwitz MS

更新日期：1974-05-01 00:00:00

abstract：:Transcription of herpesviral late genes is stimulated after the onset of viral DNA replication but otherwise restricted. Late gene expression in gammaherpesviruses requires the coordination of six early viral proteins, termed viral transactivation factors (vTFs). Here, we mapped the organization of this protein comple...

journal_title：Journal of virology

authors： Davis ZH,Hesser CR,Park J,Glaunsinger BA

更新日期：2015-10-14 00:00:00

abstract：:Previous studies have demonstrated that the genetic determinants of simian immunodeficiency virus (SIV) neurovirulence map to the env and nef genes. Recent studies from our laboratory demonstrated that SIV replication in primary rhesus macaque astrocyte cultures is dependent upon the nef gene. Here, we demonstrate tha...

journal_title：Journal of virology

authors： Overholser ED,Babas T,Zink MC,Barber SA,Clements JE

更新日期：2005-04-01 00:00:00

abstract：:Human keratinocytes immortalized by full-length or early-region simian virus 40 (SV40) DNA grow in agarose and form tumors in nude mice, in contrast to keratinocytes immortalized by the E6/E7 genes of human papillomaviruses. To determine the molecular basis for this biological difference in growth, we have used the in...

journal_title：Journal of virology

authors： Yuan H,Veldman T,Rundell K,Schlegel R

更新日期：2002-11-01 00:00:00

abstract：:The complement pathway is involved in eliminating antigen immune complexes. However, the role of the C3 complement system remains largely unknown in influenza virus M2 extracellular (M2e) domain or hemagglutinin (HA) vaccine-mediated protection after vaccination. Using a C3 knockout (C3 KO) mouse model, we found that ...

journal_title：Journal of virology

authors： Kim YJ,Kim KH,Ko EJ,Kim MC,Lee YN,Jung YJ,Lee YT,Kwon YM,Song JM,Kang SM

更新日期：2018-09-26 00:00:00

abstract：:A total of 103 amber mutants of coliphage P1 were tested for lysis of nonpermissive cells. Of these, 83 caused cell lysis at the normal lysis time and have defects in particle morphogenesis. Five amber mutants, with mutations in the same gene (gene 2), caused premature lysis and may have a defect in a lysis regulator....

journal_title：Journal of virology

authors： Walker JT,Walker DH

更新日期：1980-08-01 00:00:00

abstract：:In order to analyze the function of VPg amplification in aphthoviruses, we have undertaken the first mutational analysis of the repetitive VPg-coding region using an improved foot-and-mouth disease virus (FMDV) cDNA clone from which infective viral RNA was synthesized. A set of VPg mutants was constructed by site-dire...

journal_title：Journal of virology

authors： Falk MM,Sobrino F,Beck E

更新日期：1992-04-01 00:00:00

abstract：:Storage of the dimeric (alphabeta) form of avian myeloblastosis virus (AMV) DNA polymerase in glycerol resulted in the release of the smaller alpha subunit, as detected by glycerol gradient sedimentation. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of enzyme stored in glycerol showed the conc...

journal_title：Journal of virology

authors： Papas TS,Marciani DJ,Samuel K,Chirikjian JG

更新日期：1976-06-01 00:00:00

abstract：:The development of vaccines against bluetongue, a prevalent livestock disease, has been focused on surface antigens that induce strong neutralizing antibody responses. Because of their antigenic variability, these vaccines are usually serotype restricted. We now show that a single highly conserved nonstructural protei...

journal_title：Journal of virology

authors： Marín-López A,Calvo-Pinilla E,Barriales D,Lorenzo G,Brun A,Anguita J,Ortego J

更新日期：2018-07-31 00:00:00

abstract：:The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were o...

journal_title：Journal of virology

authors： Michalides R,van Deemter L,Nusse R,Röpcke G,Boot L

更新日期：1978-09-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) protease and its substrate, the assembly protein ICP35, are involved in virion maturation. Both proteins are encoded by a single open reading frame but are translated independently from 3'-coterminal mRNAs of different sizes and are in frame. The herpesvirus shell assembles arou...

journal_title：Journal of virology

authors： Robertson BJ,McCann PJ 3rd,Matusick-Kumar L,Preston VG,Gao M

更新日期：1997-02-01 00:00:00

abstract：:Replication of the plus-stranded RNA genome of hepatitis C virus (HCV) occurs in a membrane-bound replication complex consisting of viral and cellular proteins and viral RNA. NS5B, the RNA polymerase of HCV, is anchored to the membranes via a C-terminal 20-amino-acid-long hydrophobic domain, which is flanked on each s...

journal_title：Journal of virology

authors： Lee H,Liu Y,Mejia E,Paul AV,Wimmer E

更新日期：2006-11-01 00:00:00

abstract：:Animals immunized with the human immunodeficiency virus type 1 gp160 glycoprotein or certain recombinant envelope components develop potent virus-neutralizing activity. This activity is principally due to antibodies directed toward a hypervariable region of gp120 between cysteine residues 302 and 337 and is virus isol...

journal_title：Journal of virology

authors： Skinner MA,Langlois AJ,McDanal CB,McDougal JS,Bolognesi DP,Matthews TJ

更新日期：1988-11-01 00:00:00

abstract：:The oncolytic herpes simplex virus (HSV) that has been approved for clinical practice and those HSVs in clinical trials are attenuated viruses, often with the neurovirulence gene γ134.5 and additional genes deleted. One strategy to engineer nonattenuated oncolytic HSVs consists of retargeting the viral tropism to a ca...

journal_title：Journal of virology

authors： Leoni V,Gatta V,Casiraghi C,Nicosia A,Petrovic B,Campadelli-Fiume G

更新日期：2017-04-28 00:00:00

abstract：:The glycan shield of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) protein serves as a barrier to antibody-mediated neutralization and plays a critical role in transmission and infection. One of the few broadly neutralizing HIV-1 antibodies, 2G12, binds to a carbohydrate epitope consisting of an array...

journal_title：Journal of virology

authors： Luallen RJ,Lin J,Fu H,Cai KK,Agrawal C,Mboudjeka I,Lee FH,Montefiori D,Smith DF,Doms RW,Geng Y

更新日期：2008-07-01 00:00:00

abstract：:Approximately 20 to 22 copies of adenovirus type 12 (Ad12) DNA per cell were integrated into the genome of the cell line T637. Only a few of these copies seemed to remain intact and colinear with virion DNA. All other persisting viral genomes exhibited deletions or inversions or both in the right-hand part of Ad12 DNA...

journal_title：Journal of virology

authors： Eick D,Doerfler W

更新日期：1982-04-01 00:00:00