Abstract:
:The first photocaged complexes appeared in the mid-1980s specifically to complement the ongoing work studying intracellular Ca(2+) signaling with fluorescent probes. Recently, the field of biological inorganic chemistry has focused increasingly on the homeostasis mechanisms and possible signaling functions of transition metal ions like Mn(2+), Fe(2+), Cu(+) and Zn(2+). Development of fluorescent sensors for imaging studies has been a very active area of research; however the corresponding chemical tools for delivering metal ions have received less interest. Using the roadmap provided by Ca(2+) predecessors, we describe how new photocaged complexes are being developed, and highlight some of the obstacles that must be overcome to investigate an emerging area in metal ion biology with different requirements.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Gwizdala C,Burdette SCdoi
10.1016/j.cbpa.2012.11.015subject
Has Abstractpub_date
2013-04-01 00:00:00pages
137-42issue
2eissn
1367-5931issn
1879-0402pii
S1367-5931(12)00149-4journal_volume
17pub_type
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