Abstract:
:The ability of cobalamin to coordinate different upper axial ligands gives rise to a diversity of reactivity. Traditionally, adenosylcobalamin is associated with radical-based rearrangements, and methylcobalamin with methyl cation transfers. Recently, however, a new role for adenosylcobalamin has been discovered as a light sensor, and a methylcobalamin-dependent enzyme has been identified that is suggested to transfer a methyl anion. Additionally, recent studies have provided a wealth of new information about a third class of cobalamin-dependent enzymes that do not appear to use an upper ligand. They function in reductive dehalogenations and epoxide reduction reactions. Finally, mechanistic details are beginning to emerge about the cobalamin-dependent S-adenosylmethionine radical enzyme superfamily for which the role of cobalamin has been largely enigmatic.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Bridwell-Rabb J,Drennan CLdoi
10.1016/j.cbpa.2017.01.013subject
Has Abstractpub_date
2017-04-01 00:00:00pages
63-70eissn
1367-5931issn
1879-0402pii
S1367-5931(17)30013-3journal_volume
37pub_type
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