Enzyme catalysed tandem reactions.

Abstract:

:To transfer to the laboratory, the excellent efficiency shown by enzymes in Nature, biocatalysis, had to mimic several synthetic strategies used by the living organisms. Biosynthetic pathways are examples of tandem catalysis and may be assimilated in the biocatalysis field for the use of isolated multi-enzyme systems in the homogeneous phase. The concurrent action of several enzymes that work sequentially presents extraordinary advantages from the synthetic point of view, since it permits a reversible process to become irreversible, to shift the equilibrium reaction in such a way that enantiopure compounds can be obtained from prochiral or racemic substrates, reduce or eliminate problems due to product inhibition or prevent the shortage of substrates by dilution or degradation in the bulk media, etc. In this review we want to illustrate the developments of recent studies involving in vitro multi-enzyme reactions for the synthesis of different classes of organic compounds.

journal_name

Curr Opin Chem Biol

authors

Oroz-Guinea I,García-Junceda E

doi

10.1016/j.cbpa.2013.02.015

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

236-49

issue

2

eissn

1367-5931

issn

1879-0402

pii

S1367-5931(13)00030-6

journal_volume

17

pub_type

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