Abstract:
BACKGROUND:Aqueous extract of Pleurotus tuberregium (PT) has been shown to reduce intraocular pressure (IOP) but the underlying mechanism has not been explained. PURPOSE:To investigate the effect of PT on the bovine iris in vitro in comparison with acetylcholine (ACh). METHOD:Strips of the iris were mounted in 10 ml organ baths and exposed to increasing concentrations of PT, ACh and a combination of both agents. The effect of atropine on the responses to the agents was also investigated. RESULTS:PT and ACh separately caused contractile responses on the iris, but their effect reduced with higher concentrations. Combination of PT and ACh did not significantly alter the reduced responses seen with high concentrations of either agent. Atropine completely abolished the contractile responses of the agents. CONCLUSION:The contractile effect of PT on muscarinic receptor-containing iris muscle may explain its IOP reducing property.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Akinlabi GA,Asowata OE,Ozolua RI,Akpaja OO,Iyawe Vdoi
10.3109/02713683.2012.747615subject
Has Abstractpub_date
2013-03-01 00:00:00pages
353-7issue
3eissn
0271-3683issn
1460-2202journal_volume
38pub_type
杂志文章abstract:PURPOSE:Previous studies showed that lutein and zeaxanthin, the major human retinal carotenoids, are concentrated in the macula. In this study, the carotenoids in human macular and peripheral retina and the retinal pigment epithelium (RPE) were analyzed. They were also determined in the rod outer segments (ROS) before ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.6.491.5276
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:To evaluate the feasibility of retinal vein bypass surgery for induced branch retinal-vein occlusion (BRVO) in the living porcine eye. METHODS:Fifteen minipigs were used in the study. Seven days before vascular surgery, hyaluronidase and plasmin were intravitreally injected for induction of posterior vitreous ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.997887
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Several procedures in cataract surgery carry the risk of high temperature increases in the capsular bag. The present study was undertaken to determine the shrinkage temperature of the human lens capsule and to investigate the effect of temperature on the mechanical behavior of the lens capsule. METHOD:Thermal-...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.5.470.5198
更新日期:1998-05-01 00:00:00
abstract:PURPOSE:To determine, by a plaque reduction assay, the in vitro efficacy of novel antiviral agents in the treatment of feline herpes virus 1 (FHV-1) keratitis in the domestic cat (Felis felis). MATERIALS AND METHODS:A standard plaque reduction assay was performed using a laboratory strain of FHV-1 and embryo-derived f...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490504849
更新日期:2004-08-01 00:00:00
abstract::The selective DA2 agonist, N-0437, produced an acute reduction in intraocular pressure (IOP) and pupil diameter (PD) when applied topically to the eyes of normal monkeys. Ocular hypotension and miosis were primarily unilateral in nature, dose-related and lasted 3 to 5 hours following drug instillation. In normal monke...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688708997557
更新日期:1987-11-01 00:00:00
abstract::Using an animal model of retinoblastoma in inbred rats and cultured human adenovirus type 12-induced retinoblastoma-like tumor cells (RAO 188), complement-dependent cytotoxicity was determined by measuring release of 3H-uridine labelled RNA. Sera from rats in which tumors did not grow after adenovirus type 12 inoculat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019973
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:To compare the intensity of posterior capsule opacification (PCO) between two intraocular lenses (IOLs) of the same optic material, but with different haptic design (1-piece vs. 3-piece). METHODS:This prospective intraindividual controlled cohort study comprised eighty eyes of 40 patients with bilateral age...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2012.717242
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of gatifloxacin ophthalmic solution 0.3% (Zymar, Allergan, Inc., Irvine, CA, USA) on corneal endothelial cell density and morphology and to measure gatifloxacin penetration into aqueous humor. METHODS:This was a single-center, open-label clinical study. Ten patients undergoing standard c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680590968556
更新日期:2005-07-01 00:00:00
abstract:AIM:To compare patient satisfaction and experience after external dacryocystorhinostomy (EX-DCR) versus transcanalicular DCR (TC-DCR) with a diode laser and to evaluate the change in quality of life following simultaneous bilateral DCR. METHODS:Prospective evaluation of 38 eyes of 19 patients with bilateral nasolacrim...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.658488
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To compare the clinical outcomes following Descemet's membrane endothelial keratoplasty (DMEK) with 100% air tamponade versus 10% sulfur hexafluoride (SF6) tamponade. METHODS:Retrospective analysis of 108 consecutive DMEK cases subdivided by anterior chamber tamponade with 54 eyes receiving 10% SF6 and 54 eyes...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1431286
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:To investigate epithelial cell adhesion and proliferation on a newly developed elastin-like polymer (ELP) that mimics the functional characteristics of extracellular matrices. MATERIALS AND METHODS:A genetically engineered ELP with cell attachment sequences was adsorbed onto glass coverslips as 1, 2, or 3 mole...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802542053
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Oxidative damage of lens tissue contributes to the formation of age-related cataract. Pi-class glutathione-S-transferase (GSTP1) plays a role in the removal of oxidative adducts by transferring them to glutathione. To assess epigenetic regulation of GSTP1 and its potential role in age-related nuclear cataract (...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1185129
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:The high prevalence of positive family history of keratoconus (KC) in KC patients is well-known. However, the results regarding the association between family history of KC and disease severity are controversial. The aim of this study was to evaluate the possible association between family history and severity ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1128553
更新日期:2016-11-01 00:00:00
abstract::We have either introduced into the vitreous space or perfused through the anterior chamber of macaque monkey eyes two anionic tracers, anionic ferritin (AF) and horseradish peroxidase (HRP) and a cationic probe, cationic ferritin (CF). We have observed that the anionic molecules, but not the cationic one, are transpor...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688509025167
更新日期:1985-04-01 00:00:00
abstract:PURPOSE:Considerable evidence suggests that both axial and peripheral refraction play important roles in eye growth control. The large variability in peripheral refraction seen in adults and children indicates that the peripheral retina is exposed to a wide range of refractive errors. The current lack of appropriate me...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.27.2.61.15454
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:Whereas many previous studies have identified the association between sustained near work and myopia, few have assessed the influence of concomitant levels of cognitive effort. This study investigates the effect of cognitive effort on near-work induced transient myopia (NITM). METHODS:Subjects comprised of six...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.27.6.363.18190
更新日期:2003-12-01 00:00:00
abstract:PURPOSE:Retinal ischemia and neovascularization (NV) are important components of many retinal disorders. To facilitate further investigation of retinal ischemia and neovascularization, we sought to develop a reproducible in vivo experimental model of venous occlusion by photodynamic thrombosis in rats. METHODS:After a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.1.26.5116
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Experiments were performed to evaluate the effect of various pro- and anti-inflammatory cytokines on the human fetal retinal pigment epithelium's (HFRPE) expression of major histocompatibility complex (MHC) and costimulatory molecules. METHODS:Pure cultures of HFRPE cells were isolated. HFRPE cells were incuba...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.4.285.5456
更新日期:2001-10-01 00:00:00
abstract::The immunochemical reactivities of the alpha A and alpha B subunits from bovine alpha-crystallin have been compared using 5 monoclonal antibodies and 2 polyvalent antisera. Each subunit bound the same maximum amount of antibody, regardless of its source, and each subunit was able to completely displace alpha-crystalli...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609020047
更新日期:1986-03-01 00:00:00
abstract:PURPOSE:To investigate the effect of shaking on corneal endothelial preservation. METHODS:Thirty-six dog corneal buttons were obtained under standard eye bank procedure, after the animals had been sacrificed for cardiovascular experiments in the surgical department. They were equally divided into two groups. In Group ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.11.1111.5111
更新日期:1997-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to examine the functional connectivity between the primary visual cortex and other cortical areas during rest in normal subjects and patients with comitant strabismus using functional magnetic resonance imaging (fMRI). METHODS:A prospective, observational study was conducted. Ten pati...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1540642
更新日期:2019-03-01 00:00:00
abstract::The effect of monensin on the cytotoxic effect of antitransferrin receptor immunotoxin (IT) was determined on cultured, human retinal pigment epithelial (hRPE) cells. Human RPE cells were treated with 0.1-10,000 ng/ml IT with and without 0.01-0.1 microM monensin, a lysosomotropic reagent that can influence IT activity...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689308999495
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to characterize a standardized porcine ex-vivo testing system for intraocular pressure (IOP) monitoring after vitrectomy with different endotamponades. METHODS:Twenty-four pig eyes, six per endotamponade group were obtained immediately postmortem. After pars plana vitrectomy, vitreous...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1297461
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To evaluate the inhibitory effect of human fetal retinal pigment epithelium (HFRPE) on the activation of human T-cells. METHODS:Pure cultures of HFRPE cells were incubated with purified human T-cells in three different activation assays: 1) allogenic peripheral blood mononuclear cells; 2) OKT3 coated beads in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.6.430.5269
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To characterize the effect of glutamate receptor activation/inhibition on the secretion of vascular endothelial growth factor (VEGF) in retina-specific glial (Müller) cells under experimental conditions of hyperglycemia and hypoxia, two intrinsic pathologic conditions of diabetic retinopathy. METHODS:Purified ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.483312
更新日期:2010-08-01 00:00:00
abstract::Water-soluble (WS) and water-insoluble (WI) crystallins were prepared from calf and bovine lenses. The WS-crystallins were analyzed by capillary isotachophoresis and by immunoelectrophoresis with polyvalent and alpha-, beta-, gamma-crystallin specific antisera. The WI-crystallins were first solubilized in formamide an...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409065590
更新日期:1984-05-01 00:00:00
abstract::The objective of this study was to determine if 20:5n-3 or 22:6n-3 is the primary precursor of very-long-chain fatty acids (VLCFAs; C24-C36) synthesized in retina. Rats were fed semisynthetic, nutritionally complete diet containing 20% (w/w) fat with 3% (w/w) of 22:6n-3. After 6 weeks feeding, the vitreal fluid of eac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680500246957
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To study the association of cell proliferation in uveal melanoma with the mean of the 10 largest nucleoli (MLN), microvascular prognostic factors, and survival. METHODS:Population-based, retrospective cohort study of 167 choroidal and ciliary body melanomas enucleated from 1972 to 1981. Mouse monoclonal antibo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680500478535
更新日期:2006-01-01 00:00:00
abstract::Epsilon is a recently described eye lens protein from Rana temporaria, an anuran amphibian. It is oligomeric with a subunit M.W. of 35K. The cDNA coding for 35K E- in frog lens does not show any homology with cDNA's coding for alpha-, beta-, gamma-, and delta-crystallins. Immunologically, it also does not react with a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609000014
更新日期:1986-10-01 00:00:00
abstract::5-Fluorouracil (5-FU) and Mitomycin C (MMC) are used as adjunct chemotherapy during glaucoma filtering surgery to suppress conjunctival fibroblast proliferation. Since part of these agents may gain access to the anterior chamber and cause cytotoxicity to the corneal endothelium we set up an in vitro system to establis...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209001812
更新日期:1992-06-01 00:00:00