Does benign prostatic hyperplasia treatment with alpha-blockers affect prostate cancer risk?

Abstract:

PURPOSE OF REVIEW:To determine whether alpha-blockers, commonly used for the treatment of benign prostatic hyperplasia, are associated with prostate cancer risk. RECENT FINDINGS:Alpha-blockers have been associated with a reduced risk of prostate cancer aggressiveness in some observational studies and an increased risk in other studies. However, this relationship is complex as different alpha-blockers have divergent effects in laboratory studies and there are many confounders in daily practice such as differential screening practices. SUMMARY:Both benign prostatic hyperplasia and prostate cancer are common conditions in the aging male population, such that an interaction between alpha-blockers and prostate cancer risk is clinically relevant. Prospective evidence is necessary to establish a definitive link.

journal_name

Curr Opin Urol

authors

Loeb S,Gupta A,Losonczy L,Tosoian J,Walsh PC

doi

10.1097/MOU.0b013e32835abcf2

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2-4

issue

1

eissn

0963-0643

issn

1473-6586

journal_volume

23

pub_type

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