Abstract:
PURPOSE OF REVIEW:The standard diagnosis of carcinoma in situ (CIS) of the bladder, based on white light cystoscopy and urine cytology, is limited because CIS can vary from normal-appearing mucosa to a lesion indistinguishable from an inflammatory process. Intravesical instillation of Bacillus Calmette-Guerin (BCG) remains first-line therapy; however, a significant proportion of cases persist or recur after BCG treatment. This review summarizes recent improvements in the detection and treatment of CIS. RECENT FINDINGS:The new optical technologies improve CIS detection, with a potential positive impact on oncological outcomes. The usefulness of MRI-photodynamic diagnosis fusion transurethral resection in CIS detection is unclear and further studies are needed. BCG instillation remains the first-line therapy in CIS patients and seems to improve recurrence and progression rates, especially with the use of maintenance. Intravesical device-assisted therapies could be effective in both BCG-naïve and BCG-unresponsive CIS patients, but further studies are ongoing to clarify their clinical benefit. A phase II clinical trial with pembrolizumab has shown the potential effectiveness of immune checkpoint inhibitors in BCG-unresponsive CIS patients and further trials are ongoing. SUMMARY:New optical techniques increase the CIS detection rate. BCG instillation remains the first-line treatment. Immune checkpoint inhibitors could be a future alternative in BCG-naïve and BCG-unresponsive CIS patients.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Subiela JD,Rodríguez Faba Ó,Guerrero-Ramos F,Aumatell J,Breda A,Palou Jdoi
10.1097/MOU.0000000000000758subject
Has Abstractpub_date
2020-05-01 00:00:00pages
392-399issue
3eissn
0963-0643issn
1473-6586pii
00042307-202005000-00019journal_volume
30pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The aim of this article is to identify classification and grading systems of percutaneous nephrolithotomy-related complications and evidence for the prevention and treatment of these complications. RECENT FINDINGS:A total complication rate of up to 83% following percutaneous nephrolithotomy was recog...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f46afc
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abstract:PURPOSE OF REVIEW:Nowadays, kidney cancer surgery has been focusing on a patient-tailored management, expanding the indication to nephron-sparing surgery (NSS). Starting from computer tomography images, 3D models can be created, allowing a never experienced before understanding of surgical anatomy. Once obtained the mo...
journal_title:Current opinion in urology
pub_type: 杂志文章
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200201000-00006
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abstract:PURPOSE OF REVIEW:The recent increase in research with regard to premature ejaculation has led to a significant number of new papers looking at the diagnosis, definition, aetiology and management of this condition. RECENT FINDINGS:The intravaginal ejaculatory latency time remains the primary measure of ejaculatory tim...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
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journal_title:Current opinion in urology
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doi:10.1097/MOU.0b013e32835b0ad2
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journal_title:Current opinion in urology
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journal_title:Current opinion in urology
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更新日期:2009-05-01 00:00:00
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32834d543f
更新日期:2012-01-01 00:00:00
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journal_title:Current opinion in urology
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更新日期:2015-11-01 00:00:00
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journal_title:Current opinion in urology
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the treatment options in metastatic renal cell carcinoma (mRCC) in the light of new immunotherapy results. RECENT FINDINGS:Second-line treatment strategies for treatment of mRCC after progression on first-line VEGF-targeted therapy have recently undergone a major change. Treatment guideline...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32832c90ff
更新日期:2009-07-01 00:00:00
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/mou.0b013e32831e16ce
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:In 2012, the United States Preventive Services Task Force (USPSTF) issued a grade 'D' recommendation against the use of routine prostate-specific antigen (PSA)-based screening for any men. This recommendation reflects critical misinterpretations of the available evidence base regarding benefits and ha...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000383
更新日期:2017-05-01 00:00:00
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journal_title:Current opinion in urology
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835d4cda
更新日期:2013-03-01 00:00:00
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journal_title:Current opinion in urology
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
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更新日期:2010-09-01 00:00:00
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
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journal_title:Current opinion in urology
pub_type: 杂志文章,评审
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journal_title:Current opinion in urology
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更新日期:2011-09-01 00:00:00
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journal_title:Current opinion in urology
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更新日期:2010-09-01 00:00:00
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journal_title:Current opinion in urology
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更新日期:2019-07-01 00:00:00
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更新日期:2005-05-01 00:00:00
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更新日期:2010-07-01 00:00:00
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更新日期:2020-11-01 00:00:00