Abstract:
PURPOSE OF REVIEW:This review focuses on recent advances in molecular embryology of the upper and lower urinary tract with an emphasis on clinical correlation in order to gain a better understanding for the mechanism of congenital anomalies. RECENT FINDINGS:Normal morphogenesis of the kidney, ureteral bud differentiation, ureteropelvic junction formation, and bladder and trigone development are regulated by complex epithelial-mesenchymal signaling events. Failure of these signaling events to occur at specified times results in developmental anomalies. Immunohistochemical staining using animal and human tissues provides insights into the timing of various signaling events during development. Murine knockout models examine the role of various signaling molecules in genitourinary organogenesis. Lineage studies map the fate of cells in developing genitourinary tissues. Some of the most important findings include the role of bone morphogenetic protein-4 in morphogenesis of the kidney, the importance of the mesenchyme associated with the proximal and distal segments of the ureter in directing differentiation, the role of bone morphogenetic protein-4 signaling in smooth muscle formation at the ureteropelvic junction, and the predominant contribution of bladder smooth muscle in forming the trigone. SUMMARY:Recent studies have begun to unravel the complex molecular and cellular mechanisms for many common congenital anomalies of the genitourinary tract. A more precise understanding of these developmental events may provide insights into normal and abnormal development.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Shapiro Edoi
10.1097/MOU.0b013e32832c90ffsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
427-33issue
4eissn
0963-0643issn
1473-6586journal_volume
19pub_type
杂志文章,评审abstract::Pharmacotherapy for men experiencing erectile dysfunction has undergone dramatic advances over the past 5 years with the introduction of an effective oral agent. Sildenafil has increased the pool of couples seeking treatment for this important health issue as well as expanding the numbers of physicians treating it. Re...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200111000-00011
更新日期:2001-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The pace of technology development with single-use endoscopy has led to a range of disposable ureteroscopes. We review the development of single-use scopes, deconstruct the basic design and functional characteristics of available devices, and discuss future directions for next-generation platforms. R...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000852
更新日期:2021-03-01 00:00:00
abstract:PURPOSE OF REVIEW:We outline a generic approach to using a nomogram to predict a continuous probability of failure in high-risk patients (rather than putting patients into groups), in order to identify patients whose risk exceeds a cutoff point. We discuss the goals of any staging system, what markers should be include...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-200303000-00005
更新日期:2003-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The advantages of the laparoscopic approach in the management of kidney tumors are unequivocal and the role of laparoscopy in nephron-sparing surgery is evolving. In a selected group of patients with small exophytic renal tumors laparoscopic partial nephrectomy became an alternative to open partial ne...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000135079.98882.6d
更新日期:2004-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The diagnosis and treatment of bladder cancer represents a significant financial burden to the population in the United States. Therapeutic advances in bladder cancer care have come at a high cost to payers, providers, and patients. This study describes the principals of cost-effectiveness evaluation ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32830b8910
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The shift in the diagnostic algorithm for prostate cancer to early imaging with mpMRI has resulted in many patients being diagnosed with small volume, apparently unilateral, clinically significant cancers. In these patients, a minimally invasive, nonmorbid intervention is appealing. The aim of this st...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000838
更新日期:2021-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Partial nephrectomy has become the standard of treatment for renal tumors less than 4 cm in size. Recent reports have even applied this technique for T1b lesions as well. With advancement in minimally invasive techniques, laparoscopic and robotic surgeries are performed with the advantage of decreased...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3283337b76
更新日期:2010-01-01 00:00:00
abstract::The indications for ureteroscopic lithotripsy have increased with endoscope miniaturization and powerful, precise endoscopic lithotrites like the holmium: yttrium-aluminum-garnet laser. Successful ureteropyeloscopic treatment with the currently available instrumentation and techniques is independent of the size, compo...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-199907000-00010
更新日期:1999-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The standard diagnosis of carcinoma in situ (CIS) of the bladder, based on white light cystoscopy and urine cytology, is limited because CIS can vary from normal-appearing mucosa to a lesion indistinguishable from an inflammatory process. Intravesical instillation of Bacillus Calmette-Guerin (BCG) rem...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000758
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Serenoa repens extract is a popular phytotherapeutic agent in men with lower urinary tract symptoms. Although the exact mechanism of action is unknown, the agent is generally well accepted for its easy availability and good tolerability. This paper reviews the evidence of its efficacy in comparison wi...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200501000-00011
更新日期:2005-01-01 00:00:00
abstract::This review discusses the contemporary management of urethral trauma and post-traumatic urethral strictures occurring in both the anterior and posterior urethra. Experience in the full spectrum of urethral reconstructive procedures is important. The initial management of patients relies upon adequate drainage of the b...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-199905000-00011
更新日期:1999-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Urethrovaginal fistulae are a rare condition. It is a conceptual mistake to consider urethrovaginal fistulae to be synonymous with vesicovaginal fistulae. Urethrovaginal fistulae are a different entity requiring special attention and treatment. Due to the wide variety and individuality of the clinical...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282feedd4
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Immunotherapies for urological malignancies have made tremendous progress by targeting immune checkpoints and have been implemented in clinical practice nowadays. Though siginifcant number of patients does not respond to immunotherapy. Biomarkers could help to predict response to treatment, but are st...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000465
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to outline the initial development of histotripsy, a noninvasive image-guided focused ultrasound technology that mechanically homogenizes targeted tissues and to describe the results of preclinical translational research directed toward urologic applications. RECENT FINDING...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000001
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Phosphodiesterase 5 (PDE-5) inhibitors are established as first-line therapy in erectile dysfunction. There is emerging evidence that they may have a role in treating patients with lower urinary tract symptoms (LUTS) from benign prostatic hypertrophy. RECENT FINDINGS:All three commonly used PDE-5 inh...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328316c357
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to analyze and discuss all recently published articles associated with neurogenic voiding discussion providing readers with the most updated knowledge and trigger for further research. RECENT FINDINGS:They include the proposal of a novel classification system for the pathophysiology ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000392
更新日期:2017-05-01 00:00:00
abstract::Recent developments in renal magnetic resonance angiography have led to a significant improvement in the technical success rate and diagnostic accuracy of the methods. Specifically, three-dimensional contrast-enhanced magnetic resonance angiography methods have been shown to provide a more reliable depiction of renal ...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199803000-00006
更新日期:1998-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To perform a bicenter, retrospective study of perioperative outcomes of retroperitoneal versus transperitoneal robotic-assisted laparoscopic partial nephrectomy (RALPN) and assess costs using time-driven activity-based costing (TDABC). We identified 355 consecutive patients who underwent RALPN at Univ...
journal_title:Current opinion in urology
pub_type: 杂志文章,多中心研究
doi:10.1097/MOU.0000000000000483
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:A dedicated operating room with fluoroscopic imaging capability and adequate data connectivity is important to the success of any endourology program. Proper understanding of the recent developments in technology in relation to operating room is necessary before planning an endourology operating room....
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835d3133
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Better understanding of renal cell carcinoma biology has led to a new era of targeted therapy in the management of metastatic renal cell carcinoma. This review provides an updated survey of the recently reported and ongoing clinical trials that will help to further define the role of these novel drugs...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32833c86f8
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Overdiagnosis has become a major problem in medicine in general and cancer in particular. This is a summary of this problem. RECENT FINDINGS:Because of earlier detection, the nature of cancer has changed, from a disease usually diagnosed at a late and incurable stage to a heterogeneous condition that...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32835259aa
更新日期:2012-05-01 00:00:00
abstract::Sacral neuromodulation as a treatment for urge incontinence in patients with an unstable bladder is the subject of ongoing clinical studies. Although approximately 75% of the patients treated with a permanent sacral foramen electrode implant have experienced significant improvements, it is now also clear that there is...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199807000-00005
更新日期:1998-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Secondary data analysis has become increasingly common in health services research, specifically comparative effectiveness research. While a comprehensive study of the techniques and methods for secondary data analysis is a wide-ranging topic, we sought to perform a descriptive study of some key metho...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000407
更新日期:2017-07-01 00:00:00
abstract::Molecularly based novel therapeutic agents are needed to address the problem of locally recurrent, or metastatic, advanced hormone-refractory prostate cancer. Recent basic science advances in mechanisms of gene expression, vector delivery, and targeting have rendered clinically relevant gene therapy to the prostatic f...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200109000-00007
更新日期:2001-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Benign prostatic hyperplasia is the most common human neoplasm and it is the most frequent tumour requiring surgical treatment in men. Not surprisingly, interest centres on either understanding of prostatic growth during ageing or on various medical or interventional treatments. RECENT FINDINGS:Recen...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200301000-00003
更新日期:2003-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Surgical training has dramatically changed over the last decade. It has become not only the way to prepare surgeons for their everyday work, but also a way to certify their skills thus increasing patient safety. This article reviews advances in the use of machine learning and artificial intelligence a...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000824
更新日期:2020-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Therapies for the treatment of severe male factor infertility have advanced well beyond our knowledge of the conditions we are treating. An intact Y chromosome is necessary for optimal spermatogenesis. It is imperative for the clinician to understand the molecular basis and clinical implications of an...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32831367dc
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:With the expanding use of new technology in the treatment of clinically localized prostate cancer (PCa), the financial burden on the healthcare system and the individual has been important. Robotics offer many potential advantages to the surgeon and the patient. We assessed the potential cost-effectiv...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32834d543f
更新日期:2012-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Update on recent regenerative medicine approaches to the treatment of stress urinary incontinence (SUI) caused by intrinsic sphincter deficiency (ISD). RECENT FINDINGS:In the treatment of female SUI/ISD, results using different types of cellular therapy have been disappointing, and new approaches are...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000617
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent developments in the diagnosis and treatment of penile cancer, we reviewed the medical literature from 1 May 2002 to 1 June 2003 on the incidence, aetiology, staging, diagnosis and treatment of penile cancer by a Medline search. RECENT FINDINGS:The diagnostic tools and treatment modal...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000098068.73234.28
更新日期:2003-11-01 00:00:00