Cancer overdiagnosis and overtreatment.

Abstract:

PURPOSE OF REVIEW:Overdiagnosis has become a major problem in medicine in general and cancer in particular. This is a summary of this problem. RECENT FINDINGS:Because of earlier detection, the nature of cancer has changed, from a disease usually diagnosed at a late and incurable stage to a heterogeneous condition that varies from clinically insignificant to rapidly aggressive. Screening programs for cancer have resulted in a dramatic increase in the diagnosis of clinically insignificant disease, balanced by improved survival and mortality because of significant cancers being diagnosed at a more curable stage. Overdiagnosis requires the presence of microfocal disease and a screening test to identify this. This exists for breast, prostate, and thyroid cancers, and to a lesser degree for renal and lung cancer. The problem of cancer overdiagnosis and overtreatment is complex, with numerous causes and many trade-offs. It is particularly important in prostate cancer, but is a major issue in many other cancer sites. Screening for prostate cancer appears, based on the best data from randomized trials, to significantly reduce cancer mortality. SUMMARY:Reducing overtreatment in patients diagnosed with indolent disease is critical to the success of screening.

journal_name

Curr Opin Urol

authors

Klotz L

doi

10.1097/MOU.0b013e32835259aa

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

203-9

issue

3

eissn

0963-0643

issn

1473-6586

pii

00042307-201205000-00007

journal_volume

22

pub_type

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