Abstract:
PURPOSE OF REVIEW:Management of men with benign prostatic hyperplasia should reduce the lifetime risk of acute urinary retention and the need for benign prostatic hyperplasia-related surgery. A number of recent studies demonstrate that 5alpha-reductase inhibitors are unique in providing a long-term combination of improvements in symptoms and flow, and reductions in the risks of acute urinary retention and surgical intervention. RECENT FINDINGS:The 5alpha-reductase inhibitor finasteride was shown to reduce the risk of retention and surgery in men with large prostate volumes and/or high PSA. Recent studies have examined the role of adding an alpha1-blocker to 5alpha-reductase inhibitor in short- or long-term combination. The Medical Therapy of Prostatic Symptoms study randomised 3,047 men with benign prostatic hyperplasia to treatment with a 5alpha-reductase inhibitor (finasteride), an alpha1 blocker (doxazosin), a combination of both, or placebo. Only treatment arms containing 5alpha-reductase inhibitor therapy were associated with longer-term significant reductions in the risk of acute urinary retention and invasive therapy for benign prostatic hyperplasia. Three randomised, two-year, placebo-controlled studies have assessed the clinical relevance of the >93% DHT suppression provided by dutasteride. Dutasteride was also associated with a reduction in the risk of acute urinary retention of 57%, and a reduction of 48% in the risk of surgical intervention compared with placebo after 2 years. SUMMARY:Short-term combination of 5alpha-reductase inhibitor and alpha-blockade are optimal in providing symptomatic improvement among patients who require symptom relief, while enabling the initiation of 5alpha-reductase inhibitor therapy to reduce the risk of subsequent acute urinary retention or benign prostatic hyperplasia-related surgery in men who are at greater risk of disease progression.
journal_name
Curr Opin Uroljournal_title
Current opinion in urologyauthors
Djavan B,Waldert M,Ghawidel C,Marberger Mdoi
10.1097/00042307-200401000-00010subject
Has Abstractpub_date
2004-01-01 00:00:00pages
45-50issue
1eissn
0963-0643issn
1473-6586pii
00042307-200401000-00010journal_volume
14pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This review will summarize the most recent preclinical data from the leading US laboratories regarding the application of gene therapy to the treatment of erectile dysfunction. The implications of these findings in the field of gene therapy in general, and more specifically to the treatment of non-lif...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200211000-00010
更新日期:2002-11-01 00:00:00
abstract::Testicular microlithiasis is an uncommon condition that is characterized by calcifications within the lumina of seminiferous tubules. It is usually an incidental finding on high frequency scrotal sonography. Testicular microlithiasis is a benign condition but is associated with testicular malignancies. Recent reports ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200003000-00009
更新日期:2000-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Phosphodiesterase 5 (PDE-5) inhibitors are established as first-line therapy in erectile dysfunction. There is emerging evidence that they may have a role in treating patients with lower urinary tract symptoms (LUTS) from benign prostatic hypertrophy. RECENT FINDINGS:All three commonly used PDE-5 inh...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328316c357
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Overactive bladder affects 10-12% of men, of which 13% are refractory to medical therapy and seek second-line treatment. This places a substantial clinical and economic burden on the National Health Service United Kingdom. RECENT FINDINGS:This review identifies current evidence for the use of onabotu...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.MOU.0000434594.87575.26
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Transurethral resection of prostate is the gold standard for the surgical management of benign prostate hyperplasia. Bipolar devices allow transurethral resection of prostate with saline irrigation, which lessens water intoxication and negates the need for diathermy pad and unwanted stimulation of the...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f194db
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The success in the use of the tension-free midurethral sling procedures (tension-free vaginal tape, suprapubic arch, transobturator tape) has dramatically altered the approach to the surgical management of stress urinary incontinence in women and marked a resurgence in the use of mesh. We will analyze...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000232042.95427.9f
更新日期:2006-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Issues relating to the disease are critical in the diagnosis, management, and prognostication of prostate cancer. RECENT FINDINGS:New data have emerged regarding the disease of prostate cancer and its precursors. The diagnosis of prostate cancer on needle biopsy has been refined because of the recent...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000193389.31727.9b
更新日期:2006-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses on recent advances in molecular embryology of the upper and lower urinary tract with an emphasis on clinical correlation in order to gain a better understanding for the mechanism of congenital anomalies. RECENT FINDINGS:Normal morphogenesis of the kidney, ureteral bud differentiat...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32832c90ff
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:We review the concepts surrounding prostate cancer prevention strategies with 5-alpha reductase inhibitors (5-ARIs) and the controversies associated with their use. RECENT FINDINGS:Updated data have shown no increased risk of death from the diagnosis of higher risk cancer; however, 5-ARIs remain cont...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000464
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate recent developments in predicting the failure of shockwave lithotripsy when treating patients with urinary tract stones. RECENT FINDINGS:Although the features of patients with stones, as well as of the stones themselves, associated with refractoriness to shockwave lithotripsy are fairly w...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000193373.22318.68
更新日期:2006-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to outline the initial development of histotripsy, a noninvasive image-guided focused ultrasound technology that mechanically homogenizes targeted tissues and to describe the results of preclinical translational research directed toward urologic applications. RECENT FINDING...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000001
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Robotic assisted simple prostatectomy (RASP) represents a minimally invasive evolution of traditional open simple prostatectomy for the surgical treatment of severe lower urinary tract symptoms (LUTS) because of benign prostatic enlargement (BPE). Aim of the present review is to summarize the most rec...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000499
更新日期:2018-05-01 00:00:00
abstract::This review discusses the contemporary management of urethral trauma and post-traumatic urethral strictures occurring in both the anterior and posterior urethra. Experience in the full spectrum of urethral reconstructive procedures is important. The initial management of patients relies upon adequate drainage of the b...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-199905000-00011
更新日期:1999-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an overview of relevant data available and updated recommendations for management of pediatric patients with pheochromocytoma (PCC). RECENT FINDINGS:Much of the available data surrounding pediatric PCC is in the form of case reports and case series. With the accumulation of data over time,...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000650
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Training in female urology in Europe so far has been a national focus of individual European countries. Because of reasons like differentiation in pathology, activities of other specialisms like gynaecology and reimbursement issues, the way in which extra training in female urology is organized varies...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32832ae1a4
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To give an overview of current options for conservative treatment of patients failing intravesical bacillus Calmette-Guerin (BCG) and to discuss emerging approaches with potential future clinical applications. RECENT FINDINGS:Radical cystectomy is the standard-of-care for patients failing BCG therapy...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/MOU.0000000000000593
更新日期:2019-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Benign prostatic hyperplasia is the most common human neoplasm and it is the most frequent tumour requiring surgical treatment in men. Not surprisingly, interest centres on either understanding of prostatic growth during ageing or on various medical or interventional treatments. RECENT FINDINGS:Recen...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200301000-00003
更新日期:2003-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Radical prostatectomy is the standard treatment for localized prostate cancer; its translation to a laparoscopic approach is considered today not only as feasible and reproducible but also as a valid and teachable alternative to its open counterpart. Beyond the "classical" transperitoneal antegrade ro...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/01.mou.0000160621.05742.a4
更新日期:2005-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Prostate cancer is the most commonly diagnosed malignancy in men. Gray-scale ultrasound-guided systematic biopsy is the standard of care for prostate cancer detection in men with an elevated prostate-specific antigen or an abnormal digital rectal examination. Systematic biopsy may miss up to 35% of cl...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e328011b85c
更新日期:2007-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the most current literature regarding the management of neurogenic bladder in children. RECENT FINDINGS:Several recent papers have addressed the investigation and management of children with neurogenic bladder. Bladder wall thickness as measured by ultrasound may identify the children with ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32832c9178
更新日期:2009-07-01 00:00:00
abstract::Sacral neuromodulation as a treatment for urge incontinence in patients with an unstable bladder is the subject of ongoing clinical studies. Although approximately 75% of the patients treated with a permanent sacral foramen electrode implant have experienced significant improvements, it is now also clear that there is...
journal_title:Current opinion in urology
pub_type: 杂志文章
doi:10.1097/00042307-199807000-00005
更新日期:1998-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to look into recent updates on the management of neurogenic stress urinary incontinence (NSUI) in adult females. RECENT FINDINGS:Recently, a small number of studies have investigated different surgical modalities in treatment of NSUI in adult females including artificial ur...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000785
更新日期:2020-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Partial nephrectomy provides equivalent long-term oncologic and superior functional outcomes as radical nephrectomy for T1a renal masses. Herein, we review the various vascular clamping techniques employed during minimally invasive partial nephrectomy, describe the evolution of our partial nephrectomy...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000140
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses on novel imaging techniques used for guiding urologic procedures that are likely to provide additional opportunities to physicians in the years to come. RECENT FINDINGS:In the past, most image-guided urologic procedures have utilized two-dimensional x-ray images. This review will ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282f1c5d3
更新日期:2008-01-01 00:00:00
abstract::Pharmacotherapy for men experiencing erectile dysfunction has undergone dramatic advances over the past 5 years with the introduction of an effective oral agent. Sildenafil has increased the pool of couples seeking treatment for this important health issue as well as expanding the numbers of physicians treating it. Re...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-200111000-00011
更新日期:2001-11-01 00:00:00
abstract::During the past year no new therapies for prostatic outflow obstruction were introduced. Instead, research focused on refinement of treatments previously available. Further reports on the efficacy and safety of alpha 1-adrenergic receptor subtype selective agents have appeared. The long-term effects of finasteride on ...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/00042307-199901000-00007
更新日期:1999-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the treatment options in metastatic renal cell carcinoma (mRCC) in the light of new immunotherapy results. RECENT FINDINGS:Second-line treatment strategies for treatment of mRCC after progression on first-line VEGF-targeted therapy have recently undergone a major change. Treatment guideline...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0000000000000456
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Therapies for the treatment of severe male factor infertility have advanced well beyond our knowledge of the conditions we are treating. An intact Y chromosome is necessary for optimal spermatogenesis. It is imperative for the clinician to understand the molecular basis and clinical implications of an...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e32831367dc
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To perform a bicenter, retrospective study of perioperative outcomes of retroperitoneal versus transperitoneal robotic-assisted laparoscopic partial nephrectomy (RALPN) and assess costs using time-driven activity-based costing (TDABC). We identified 355 consecutive patients who underwent RALPN at Univ...
journal_title:Current opinion in urology
pub_type: 杂志文章,多中心研究
doi:10.1097/MOU.0000000000000483
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Urethrovaginal fistulae are a rare condition. It is a conceptual mistake to consider urethrovaginal fistulae to be synonymous with vesicovaginal fistulae. Urethrovaginal fistulae are a different entity requiring special attention and treatment. Due to the wide variety and individuality of the clinical...
journal_title:Current opinion in urology
pub_type: 杂志文章,评审
doi:10.1097/MOU.0b013e3282feedd4
更新日期:2008-07-01 00:00:00